DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and Phc1

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_006505561.1	Gene:	Phc1 / 13619	MGIID:	103248	Length:	1040	Species:	Mus musculus

Alignment Length:	977	Identity:	200/977 - (20%)
Similarity:	301/977 - (30%)	Gaps:	336/977 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRR-----SRSVSP-----------CS 91
            |..|..|.|.:            .::.||...:|...:|.:     .:::.|           .|
Mouse   223 AQSPGVHADAD------------QVQNLAVRNQQASAQGPQMPGSTQKAIPPGASPVSGLSQTSS 275

  Fly    92 RYPAVAETARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGAAGQ--------------- 141
            :..|||:.:...|.:||.||..|.  .|...|..:...|.||...|..||
Mouse   276 QALAVAQASSGASGQSLNLSQAGG--GSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRKG 338

  Fly   142 ---------AATPTTSQ------LSAPASSASSSSMSSSSAGSTCTTNANTA-SVAAAYAAFYLE 190
                     |.|.|.||      .||.|..|.:......|.|...|..|..| |.....:|.|.:
Mouse   339 TGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTATPAPSQTLISSATYTQ 403

  Fly   191 KVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSS----QPSLGHSVKRERLS 251
            ...|..:...:.     ||.......|         ...|..:||..    |..|.|:....:|:
Mouse   404 IQPHSLIQQQQQ-----IHLQQKQVVI---------QQQIAIHHQQQFQHRQSQLLHTATHLQLA 454

  Fly   252 PGSNSSSHNGELTVSSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQQQQQQSLQQQQR---L 313
            ....                                       ..|||||||||..||||:   |
Mouse   455 QQQQ---------------------------------------QQQQQQQQQQQQQQQQQQGTTL 480

  Fly   314 SPPSGPSM---------------ATATTTSSLSSS----------------------------SS 335
            :.|..|.:               .|......|.||                            ..
Mouse   481 TAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPVAPIKPPQL 545

  Fly   336 ASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSN----------SSSNISGSSNN 390
            .:|..||:.....|:|:..:.|....|.|..|....||.::...          ..::::.|..:
Mouse   546 GAAKMSATQQPPPHIPVQVVGTRQPGSAQAQALGLAQLAAAVPTPRGITGAVQPGQAHLASSPPS 610

  Fly   391 TKSDGGAASNATDFSTRNYSDIMRC---LAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGG 452
            :::..||              :..|   |||                    |.|.| ...|.|..
Mouse   611 SQAAPGA--------------LQECPPALAA--------------------GMTLA-PVQGTAHV 640

  Fly   453 GGGGAGGSN----SAPSSALKTASSSTGSTTTTAKK------------------LSPSAASAANS 495
            ..||...|:    ..|::....:....|...|.|.|                  |...|:.||.|
Mouse   641 VKGGPTASSPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAES 705

  Fly   496 AAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQLAPPPTAPSPTEQAKSQMAAVVAAASVSPF 560
            ..|...|.|    :|......|..::....|.:..|||.|:||.||            .|.||..
Mouse   706 PKVIEEKNS----LGEKAEPVASLNANPPNSDLVALAPTPSAPPPT------------LALVSRQ 754

  Fly   561 MTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQE-----------ILRSKQQ------RSG 608
            |.:..|..:.:.|.:           |...::...|||           .|:..::      .:|
Mouse   755 MGDSKPPQAIVKPQI-----------LTHIIEGFVIQEGAEPFPVGCSQFLKETKKPLQAGLPTG 808

  Fly   609 SNASSPSASAAG-TPRSSSTLNAALHQ---------AAQF--------VTPALIYSAQLQQQQQQ 655
            .|.|.||....| :|.......|.|.:         |.||        :|.|..|:.....|.:.
Mouse   809 LNESQPSGPLGGDSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRL 873

  Fly   656 QQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGGSSIASAAPLDLSSQPPAAKRFKAER 720
            :::: .::.|:.|....|:..||.::.....|.|                         :.|..|
Mouse   874 KRKK-MKEFQEASYARVRRRGPRRSSSDIARAKI-------------------------QGKRHR 912

  Fly   721 RASSTATTATTATTGSSTSTPSPPPLEQHDDINSGNANATLGTRSGTGTGESSAAGSGAGVAKAR 785
            ....::..:..::...:.|..||.||    .:.:|:....||   .|.|..|:....|....
Mouse   913 GQEDSSRGSDNSSYDEALSPTSPGPL----SVRAGHGERDLG---NTITTPSTPELQGINPV--- 967

  Fly   786 RRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPAL 850
                ..|...:.|||::|..|:..:..|.|..:.||.|.|||..|.||.|:||::::.:||||||
Mouse   968 ----FLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPAL 1028

  Fly   851 KL 852
            |:
Mouse  1029 KI 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	26/58 (45%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	25/56 (45%)
Phc1	XP_006505561.1	PHA03247	<509..639	CDD:223021	25/164 (15%)
		PHC2_SAM_assoc	864..970	CDD:374673	22/145 (15%)
		SAM_Ph1,2,3	971..1039	CDD:188976	26/60 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100