Protein Alignment Samuel and GPRIN1

DIOPT Version :9

• Sequence 1: NP_001260372.1
• Gene: Samuel / 34530
• FlyBaseID: FBgn0032330
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_443131.2
• Gene: GPRIN1 / 114787
• HGNCID: 24835
• Length: 1008
• Species: Homo sapiens
• Alignment Length: 1100
• Identity: 207/1100 - (18%)
• Similarity: 332/1100 - (30%)
• Gaps: 285/1100 - (25%)

  Fly    13 PAWCYSGNAPTDILQQ---KPAKATTAIV----GGRSAAQPATHDDQEAATTASTATKRKHLERL 70
            |||       ..:||:   .|....||..    |...|...|..|...:...||.|..|...::
Human     7 PAW-------LQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQ- 63

  Fly    71 ASDLRQLGKKGRRSRSVSPCSRYPAVAETARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGG 135
                    ..|..||..||                                       .|||.|.
Human    64 --------SPGMESRHRSP---------------------------------------SGAGEGA 81

  Fly   136 G---GAAGQAATPTTSQLSAPASSASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKM 197
            .   |..|..|.|:.:..| |..|.|..::.:..|..:.|..|.|:.....     :..||.|..
Human    82 SCSDGPRGSLACPSPTCFS-PQESPSKETLEAHGASISGTPEATTSGKPEP-----VSSVKTEPK 140

  Fly   198 DNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSS------------QPSL---GHSVKR 247
            .:....||..       ..::..:|..:.|:||......|            :|.:   |..|..
Human   141 SSDDRNPMFL-------EKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198

  Fly   248 ERLSPGSNSSSHNGEL-TVSSFARSRSATPS-----SSSYRGAGGGAGGGVSPSHQQQQQQQQQS 306
            .|:.|.:......|.| .|.....|::.|.|     ..|.|.....:...|.|...::::.:...
Human   199 GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSG 263

  Fly   307 LQ---QQQRLSPPS--------------GPS-MATATTTSSLSSSSS-------------ASASA 340
            .:   ..::::|.|              ||| .|......|:.|:|:             .|:..
Human   264 KEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGK 328

  Fly   341 SASASAATHMP--LHNLSTNLL--------NSIQQAAASQQQLR------SSNSNSSSNISGSSN 389
            :...|:.|..|  |..|....|        .:::...|:::..|      .::|.....:||.::
Human   329 NGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTD 393

  Fly   390 NTKSDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGG 454
            .|      ||..||.::....|.|........:....|...:.:........:...:.|.||...
Human   394 TT------ASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVS 452

  Fly   455 GGAGGSNSAPSSALKTASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAV- 518
            .|    ...|.|:.:....|.||..|:::|::|.::...|..:   |......::|.||...||
Human   453 PG----KEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVS---SGPGDPRSLGTAGPPSAVK 510

  Fly   519 --ASSGGGGSSMSQ-----LAPPPTAPS--------------PTEQAKSQMAAVVAAASVS---- 558
              .::||.|..:|.     :|....||:              |..:.|:.........|||
Human   511 AEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKV 575

  Fly   559 ---PFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNASSPSASAAG 620
               |..|  :|..||...|:        .|..|.|:.:.::..:...|.....:..:.|.||...
Human   576 VSTPGKT--VPVPSGKVDPV--------SLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKA 630

  Fly   621 TPRSSSTLNAALHQAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTT 685
            .|:|.......|........|....:..|:::..|               ||.:..|.|...:..
Human   631 QPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQ---------------ASEKVDPGSCRKAEP 680

  Fly   686 VA-----PIGDGGGGS---------SIASAAPLDLSSQPPAAKRFKAERRASSTATTATTATTGS 736
            :|     |:..|...|         |:....||.|....|::...:.:|:|..:|.:...|....
Human   681 LASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSE 745

  Fly   737 STSTPSPPPLEQHDDINSGNANATLGTRSGTGTGESSAAGSGAGVAKARRRCQAQSEEVNSWSVD 801
            ....|...|:       |....::||.:.....|...:....|.......|.:....:..||...
Human   746 GRVEPKAEPV-------SSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEAS 803

  Fly   802 ------DVCGFVGGIDICAEYVQSFRDQSIDGTG--------------LPLLTEDHLVNSLGMKL 846
                  :..|...|...|.....|..... ||.|              .|...:..|..|||
Human   804 APPPPREDAGTQAGAQACVSVAVSPMSPQ-DGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLG--- 864

  Fly   847 GPALKLRSILAKKLGGPCPCVACVAQAQQMLALQTGGAAAATGATAGAGT-----------VTGA 900
              |.:.||:..    ||....|....|...:.::.|.|.||..|......           :|..
Human   865 --AAETRSVAT----GPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWE 923

  Fly   901 VAGAGATSATTSCSIKS----EIFNGGSNG------SSSGSSSNQGSDVAAPPAATASSP 950
            |.||.........:|:.    :|...|..|      ::.......||...|||...|..|
Human   924 VYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRP 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	17/86 (20%)
		SAM	795..852	CDD:197735	15/76 (20%)
GPRIN1	NP_443131.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..859		176/965 (18%)
		GRIN_C	873..1005	CDD:291888	23/114 (20%)
		Interaction with GNAO1. /evidence=ECO:0000250	899..1008		16/84 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..986		9/40 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000