DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and DEAF1

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_066288.2	Gene:	DEAF1 / 10522	HGNCID:	14677	Length:	565	Species:	Homo sapiens

Alignment Length:	627	Identity:	111/627 - (17%)
Similarity:	199/627 - (31%)	Gaps:	174/627 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AKATTAIVGGRSAAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRRSRSVSPCSRYPA 95
            |.|..|..|| .|.:|....|:::...|.:..:|:                           .|.
Human    26 AAAAAAAAGG-EAEEPVLSRDEDSEEDADSEAERE---------------------------TPR 62

  Fly    96 VAETARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGAAGQAATPTTSQLSAPASSASSS 160
            |...|.|.:|...:..|           :||..|........|..:..|.|.:.:.|.|.:..::
Human    63 VTAVAVMAAEPGHMDMG-----------AEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTT 116

  Fly   161 SMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSS 225
            |::::::.|....:..||....       :.:..||      |.::.:|   .:.:|........
Human   117 SVANAASISGHVLSGRTALQIG-------DSLNTEK------ATLIVVH---TDGSIVETTGLKG 165

  Fly   226 SSSSIINNHQSSQPSLGHSVKRERLSPGSNSSSHNGELTVSSFARSRSATPSSSSYRGAGGGAGG 290
            .::.:....||....|....::.......:.|.::.||.|      |....|.:.|:...|..|.
Human   166 PAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPV------RCRNISGTLYKNRLGSGGR 224

  Fly   291 GVSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTTSSLSSSSSASASASASASAATHMPLHNL 355
            |             :.::|        |.:..:.|...:::..:|
Human   225 G-------------RCIKQ--------GENWYSPTEFEAMAGRAS-------------------- 248

  Fly   356 STNLLNSIQQAAASQQQLRSS---NSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLA 417
            |.:...||:.|....|.|...   |.:::|....:..:..:..|.......:..|...:.:....
Human   249 SKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTP 313

  Fly   418 AKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTA 482
            .|.::.         :|.....:|:|||.|              ..||..:           ||:
Human   314 VKKDSP---------KNITLLPATAATTFT--------------VTPSGQI-----------TTS 344

  Fly   483 KKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSG--------------GGGSSMSQLAP 533
            ..|:...||...:.||.    |:..|.|....|..|..:.              .|.....|:||
Human   345 GALTFDRASTVEATAVI----SESPAQGDVFAGATVQEASVQPPCRASHPEPHYPGYQDSCQIAP 405

  Fly   534 PPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLI---DMSSTQALLTLARAVKDAE 595
            .|.|..||...|..:.::.|.|...|..|...|      |.|:   ::|..::.|.|     :..
Human   406 FPEAALPTSHPKIVLTSLPALAVPPPTPTKAAP------PALVNGLELSEPRSWLYL-----EEM 459

  Fly   596 IQEILRSKQQRSGSNASSPSASAAGTPRSSSTLNAALHQAAQ 637
            :..:|.:.||   .......|..|.|.|.::|..|.:|..|:
Human   460 VNSLLNTAQQ---LKTLFEQAKHASTYREAATNQAKIHADAE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978
Samuel	NP_001260372.1	SAM	795..852	CDD:197735
DEAF1	NP_066288.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..62		7/55 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..190		3/27 (11%)
		SAND	198..272	CDD:279658	19/120 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	301..316		1/14 (7%)
		Interaction with LMO4. /evidence=ECO:0000250	403..478		20/88 (23%)
		zf-MYND	504..540	CDD:280009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900