DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and samd11

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_012821355.1	Gene:	samd11 / 100125007	XenbaseID:	XB-GENE-5956759	Length:	916	Species:	Xenopus tropicalis

Alignment Length:	809	Identity:	183/809 - (22%)
Similarity:	278/809 - (34%)	Gaps:	238/809 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 EKVKHEK--MD-----------------NHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQ 235
            |:|.|.|  ||                 |...:.:.::|.|:......|.|..        |:||
Frog   261 ERVNHPKDCMDGIFLQTTAPLMGLAGRENELSSIITSLHQNHQLVMPENQNKR--------NSHQ 317

  Fly   236 SSQPS----LGHSVKRERLSPGSNSSSHNGELTVSSFARSRSATPSSSSYRGAGGGAGGGVSPSH 296
            .:.||    ||   |:...||.|||     |..:.| .::||.:|..:|
Frog   318 LTFPSTDDFLG---KKRECSPNSNS-----ECPLES-KKARSESPKETS---------------- 357

  Fly   297 QQQQQQQQQSLQQQQRLSPPSGPSMATATTTSSLSSSSSASASASASASAATHM--PLHNLSTNL 359
                    |:...::||:..: |........|:|:...|...........|..|  |.||   :|
Frog   358 --------QTPLLEERLAQMT-PEEHYRRMMSALNEHGSFEEQQQRLYQLANTMAVPTHN---DL 410

  Fly   360 LNSIQQAAAS---QQQLRSSNSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKYN 421
            |.:.|:.||:   ......::..||||  .||...|.......:.:.|:.|..|.....|:.:
Frog   411 LRARQEVAAAVVRNPAAMEAHIPSSSN--SSSQRRKQGLPQHRDTSHFTDREMSHPPPLLSPQ-- 471

  Fly   422 NANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTAKKLS 486
            || |:..........:.|..||...|.|.|         ...|:.|...|............:|.
Frog   472 NA-PHIALGPHLRPPFLGVPSALCQTPGYG---------FLQPAQAEIFARQQEMLRKQNLARLE 526

  Fly   487 PSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQLAP--PPTAPSPTEQAKSQMA 549
            .||.........:|.::..::                 |..:: |.|  ||..|:
Frog   527 MSAEIIRQKELENLHRQRLLA-----------------GDPLT-LHPGLPPDHPA---------- 563

  Fly   550 AVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNASSP 614
                       :.|......| .|...::|...|:|.|...      ...|.|...:..|:|..|
Frog   564 -----------LRNVHELPEG-HPLREELSRRNAMLVLRHN------NTPLLSLNHQGVSSAPPP 610

  Fly   615 SASAAGTPRSSSTLNAALH----------QAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQ 669
            ..|.:|  |.||  ..::|          :|.:.:.......|.....::.:..:.:.:::..|.
Frog   611 KESGSG--RRSS--RKSVHHRNEPQVNQGEAKELLDQHCRDGASEGNDEEMKDSESEAEEKADSL 671

  Fly   670 HASRQSSPRS------------------TNDSTT--VAPIGDG-------GGGSSIASAAPLDLS 707
            .|.|.:|..|                  :||:.|  ..|.|..       |.|.:...:..|..|
Frog   672 RADRGASSSSHELHEGKDTLKGSESIKESNDAQTHQSLPCGPSESPTHLLGPGINKGESKYLPSS 736

  Fly   708 SQPPAAKRFKAERRASSTATTATTATTGSSTSTPSPPPLEQHDDINSGNANATLGTRSGTG---T 769
            |.||                             |.|.|......:|.......:|     |   .
Frog   737 SVPP-----------------------------PQPLPFGFPYAVNPYFHTGAMG-----GLFLD 767

  Fly   770 GESSAAGSGAGVAKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLT 834
            ||.|..                .|:::.|:|:|||.|||.:..||||.|.||:.||||..|||||
Frog   768 GEESVV----------------LEDLSKWTVEDVCSFVGSLSGCAEYTQVFREHSIDGETLPLLT 816

  Fly   835 EDHLVNSLGMKLGPALKLRSILAKKLGGPCPCVACVAQAQQMLALQTGGAAAATGATAGAGTV-- 897
            |:||:|::|:|||||||:|:.:||::|.    |..:|.......||..|..||. ...|||.:
Frog   817 EEHLLNNMGLKLGPALKIRAQVAKRIGR----VLYMASFPVAFPLQHPGLRAAE-RDLGAGEIRP 876

  Fly   898 --TGAVAGAGATSATTSCSIKSEIFNGGS 924
              ||:......::......|..:..|||:
Frog   877 PSTGSAGSPYGSTLLPPSRISPKHENGGT 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	39/66 (59%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	35/56 (63%)
samd11	XP_012821355.1	SAND	89..163	CDD:279658
		SAM_Samd7,11	777..844	CDD:188978	39/66 (59%)
		SAM	778..834	CDD:197735	35/55 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8137
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006289
OrthoInspector	1	1.000	-	-		otm48365
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100