DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art8 and Prmt6

DIOPT Version :9

Sequence 1:	NP_609478.1	Gene:	Art8 / 34528	FlyBaseID:	FBgn0032329	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_849222.3	Gene:	Prmt6 / 99890	MGIID:	2139971	Length:	378	Species:	Mus musculus

Alignment Length:	326	Identity:	130/326 - (39%)
Similarity:	177/326 - (54%)	Gaps:	42/326 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YFDEYENLEIHELMLKDRPRQEAYYNAILGNKDLFKDKIVMDVGAGTGILSAFCAKAGARLVYAV 69
            |::.|.::.:||.|:.|:.|.|||...||.|....:.|.|:||||||||||.|||:||||.||||
Mouse    50 YYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAV 114

  Fly    70 EASNVATKVALDLIEDNGLTNVVKVIQSRVEEFVLPAEAEKVDIIVSEWMGFYLLHEGMLDSVLL 134
            |||.: .:.|.:::..|||.:.|.|:...||...||   |:||.|||||||:.||||.||.|||.
Mouse   115 EASAI-WQQAREVVRLNGLEDRVHVLPGPVETVELP---ERVDAIVSEWMGYGLLHESMLSSVLH 175

  Fly   135 ARDKFLKEGGLLFPSECTIFVAPCSVPSLFDDW-----------HNVDGIKMDTFARKLRTQKSS 188
            ||.|:|||||||.|:...:||||.|...|  :|           :.||...|::||.:.....|
Mouse   176 ARTKWLKEGGLLLPASAELFVAPISDQML--EWRLGFWSQVKQHYGVDMSCMESFATRCLMGHS- 237

  Fly   189 RPEITQLNPQDLLHEGVVFHWMNLLDVEASDLDSIQFKEVITAQKAGNHQ----------GFCIW 243
                 ::..|||..|.|:........:|   |.....::.:.|...|..:          ||.:|
Mouse   238 -----EIVVQDLSGEDVLARPQRFAQLE---LARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVW 294

  Fly   244 FDVQFPGED----FVLSTSPLSPPTHWKQCVVVLPEESCENLEEKSPIAFQITMKRSAADMRKYN 304
            |.|.|||.|    .||||||..|.|||||.::.|.|.  ..:|:.:.|:.:||:..|..:.|:..
Mouse   295 FQVTFPGGDSEKPLVLSTSPFHPATHWKQALLYLNEP--VPVEQDTDISGEITLLPSPDNPRRLR 357

  Fly   305 L 305
            :
Mouse   358 I 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art8	NP_609478.1	SmtA	1..244	CDD:223574	103/259 (40%)
Art8	NP_609478.1	Methyltransf_18	40..147	CDD:289607	64/106 (60%)
Prmt6	NP_849222.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
Prmt6	NP_849222.3	Methyltransf_18	85..188	CDD:289607	64/106 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10024
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1503
OMA	1	1.010	-	-		QHG54098
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106082
Panther	1	1.100	-	-	LDO	PTHR11006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5237
SonicParanoid	1	1.000	-	-		X4197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.800