DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art8 and ERG6

DIOPT Version :9

Sequence 1:	NP_609478.1	Gene:	Art8 / 34528	FlyBaseID:	FBgn0032329	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_013706.1	Gene:	ERG6 / 855003	SGDID:	S000004467	Length:	383	Species:	Saccharomyces cerevisiae

Alignment Length:	235	Identity:	50/235 - (21%)
Similarity:	80/235 - (34%)	Gaps:	82/235 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RQEAY--YNAILGNKDLFKDKIVMDVGAGTGILSAFCAKAGARLVYAVEASNVATKVALDLIEDN 86
            |.|.|  |.|.:...||     |:|||.|.|        ..||.:......||.
Yeast   106 RHEHYLAYKAGIQRGDL-----VLDVGCGVG--------GPAREIARFTGCNVI----------- 146

  Fly    87 GLTN----VVKVIQSRVEEFVLPAEAEKVDIIVSEWMGF----------YLL----HEGMLDSVL 133
            ||.|    :.|. :...:::.|   ::::|.:..::|..          |.:    |...|:.|.
Yeast   147 GLNNNDYQIAKA-KYYAKKYNL---SDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVY 207

  Fly   134 LARDKFLKEGGLLFPSECTIFVAPCSVPSLFDDWHNVDGIKMDTFARKLRTQKSSRPEITQLNPQ 198
            ....|.||.||.....|                |...|  |.|          .:.||..::..:
Yeast   208 SEIYKVLKPGGTFAVYE----------------WVMTD--KYD----------ENNPEHRKIAYE 244

  Fly   199 DLLHEGV--VFHWMNLLDVEASDLDSIQFKEVITAQKAGN 236
            ..|.:|:  :||    :||....|.:..|:.:::...|.|
Yeast   245 IELGDGIPKMFH----VDVARKALKNCGFEVLVSEDLADN 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art8	NP_609478.1	SmtA	1..244	CDD:223574	50/235 (21%)
Art8	NP_609478.1	Methyltransf_18	40..147	CDD:289607	26/124 (21%)
ERG6	NP_013706.1	Cfa	66..>277	CDD:225139	48/230 (21%)
		Methyltransf_11	124..222	CDD:400514	25/120 (21%)
		Sterol_MT_C	306..368	CDD:400686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900