DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art8 and PRMT8

DIOPT Version :9

Sequence 1:	NP_609478.1	Gene:	Art8 / 34528	FlyBaseID:	FBgn0032329	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_062828.3	Gene:	PRMT8 / 56341	HGNCID:	5188	Length:	394	Species:	Homo sapiens

Alignment Length:	313	Identity:	113/313 - (36%)
Similarity:	170/313 - (54%)	Gaps:	20/313 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YFDEYENLEIHELMLKDRPRQEAYYNAILGNKDLFKDKIVMDVGAGTGILSAFCAKAGARLVYAV 69
            |||.|.:..|||.||||..|...|.|::..||.:||||:|:|||:||||||.|.|||||:.|:.:
Human    76 YFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGI 140

  Fly    70 EASNVATKVALDLIEDNGLTNVVKVIQSRVEEFVLPAEAEKVDIIVSEWMGFYLLHEGMLDSVLL 134
            |.|:: :..:..:|:.|.|.|::.:.:.:|||..||  .||||||:|||||:.|.:|.||::|:.
Human   141 ECSSI-SDYSEKIIKANHLDNIITIFKGKVEEVELP--VEKVDIIISEWMGYCLFYESMLNTVIF 202

  Fly   135 ARDKFLKEGGLLFPSECTIFVAPCSVPSLFDD----WHNVDGIKMDTFARKLRTQKSSRPEITQL 195
            ||||:||.|||:||....::|.........|.    |.||.|..|..    :|......|.:..:
Human   203 ARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTC----IRDVAMKEPLVDIV 263

  Fly   196 NPQDLLHEGVVFHWMNLLDVEASDLDSIQFKEVITAQKAGNH--QGFCIWFDVQFP--GEDFVLS 256
            :|:.::....:...:::..|:..:|   .|......|...|.  .....:|:::|.  .:....|
Human   264 DPKQVVTNACLIKEVDIYTVKTEEL---SFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFS 325

  Fly   257 TSPLSPPTHWKQCVVVLPEESCENLEEKSPIAFQITMKRSAADMRKYNLEVDL 309
            |:|.:|.|||||.|..|  |....:.....|...|:||.:|.::|..:..|||
Human   326 TAPDAPYTHWKQTVFYL--EDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art8	NP_609478.1	SmtA	1..244	CDD:223574	90/244 (37%)
Art8	NP_609478.1	Methyltransf_18	40..147	CDD:289607	56/106 (53%)
PRMT8	NP_062828.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..40
		SH3-binding 1. /evidence=ECO:0000269\|PubMed:17925405	29..42
		SH3-binding 2. /evidence=ECO:0000269\|PubMed:17925405	53..58
		AdoMet_MTases	115..215	CDD:100107	53/102 (52%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000305\|PubMed:26529540, ECO:0000305\|PubMed:26876602, ECO:0007744\|PDB:4X41, ECO:0007744\|PDB:5DST	119..122		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54098
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830