DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Art8 and CARM1

DIOPT Version :9

Sequence 1:	NP_609478.1	Gene:	Art8 / 34528	FlyBaseID:	FBgn0032329	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	361	Identity:	126/361 - (34%)
Similarity:	178/361 - (49%)	Gaps:	58/361 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YFDEYENLEIHELMLKDRPRQEAYYNAILGNKDLFKDKIVMDVGAGTGILSAFCAKAGARLVYAV 69
            ||..|..|...:.|::|..|...|..|||.|...||||||:|||.|:||||.|.|:||||.:|||
Human   149 YFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAV 213

  Fly    70 EASNVATKVALDLIEDNGLTNVVKVIQSRVEEFVLPAEAEKVDIIVSEWMGFYLLHEGMLDSVLL 134
            |||.:|....: |::.|.||:.:.||..:|||..||   |:||||:||.||:.|.:|.||:|.|.
Human   214 EASTMAQHAEV-LVKSNNLTDRIVVIPGKVEEVSLP---EQVDIIISEPMGYMLFNERMLESYLH 274

  Fly   135 ARDKFLKEGGLLFPSECTIFVAPCSVPSLFDD-------W-----HNVD-----GIKMDTFARKL 182
            |: |:||..|.:||:...:.:||.:...|:.:       |     |.||     |..:|.:.|
Human   275 AK-KYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFR-- 336

  Fly   183 RTQKSSRPEITQLNPQDLLHEGVVFHWMNLLDVEASDLDSIQFKEVITAQKAGNHQGFCIWFDVQ 247
                  :|.:...:.:.|:.:.|.: .:|.|:.:..||..|:.........:|...|...||||.
Human   337 ------QPVVDTFDIRILMAKSVKY-TVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVA 394

  Fly   248 FPGEDFV--LSTSPLSPPTHWKQ--CVVVLP--EESCENLEEKSPIAFQITMKRSAADM------ 300
            |.|....  |||:|..|.|||.|  |:...|  .::.:.|   |.....|..||.:.|:
Human   395 FIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTL---SGTCLLIANKRQSYDISIVAQV 456

  Fly   301 -----RKYNLEVDLLDP-----NTEEHPVPCSCHMT 326
                 :..|| :||.:|     .|...|.|.| |.|
Human   457 DQTGSKSSNL-LDLKNPFFRYTGTTPSPPPGS-HYT 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Art8	NP_609478.1	SmtA	1..244	CDD:223574	92/255 (36%)
Art8	NP_609478.1	Methyltransf_18	40..147	CDD:289607	57/106 (54%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395
		PRMT5	<172..435	CDD:282971	103/279 (37%)
		Methyltransf_18	184..283	CDD:289607	56/103 (54%)
		Transactivation domain. /evidence=ECO:0000250	499..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D840669at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820