DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup154 and NUP155

DIOPT Version :9

Sequence 1:NP_001285827.1 Gene:Nup154 / 34527 FlyBaseID:FBgn0021761 Length:1365 Species:Drosophila melanogaster
Sequence 2:NP_705618.1 Gene:NUP155 / 9631 HGNCID:8063 Length:1391 Species:Homo sapiens


Alignment Length:1422 Identity:474/1422 - (33%)
Similarity:747/1422 - (52%) Gaps:151/1422 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ERNKPGLLELTGVSQHGRATMSGLNDYDY--QSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFK 87
            :|..|.|.||..||.....|:||::|.||  |....|.   ..||.::.::.:..:|.|::|.|.
Human    37 DRMYPDLSELLMVSAPNNPTVSGMSDMDYPLQGPGLLS---VPNLPEISSIRRVPLPPELVEQFG 98

  Fly    88 HIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKY 152
            |::|:|.||:||.|.||||||||:|::|.:....|:||:||||..|::|||||||.|:|...|::
Human    99 HMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRH 163

  Fly   153 LLVLTTPIEVIVLGVTF-----GESSYNE-----MQLMNRPVFVIGTDNVSISVIKGTDDGRIFL 207
            ||||.||:::::||:::     |....|:     |||:..|::.:.|||..:..|..||:|||||
Human   164 LLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFL 228

  Fly   208 GGRDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLK-VFSEVDPIEHIEIDNSRKLLYV 271
            .|:||||||:.||||:.||.:||:|||.|:..:|::|||.|: .|||.|||..|.|||||.:||.
Human   229 AGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYT 293

  Fly   272 LTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHL 336
            .:|||||:.:|:........|:..::||.|.:.|.::..|:|.|:||.:..|..:...::....|
Human   294 RSEKGVIQVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQL 358

  Fly   337 VAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPP 401
            :|||..||||:|||              |          |..||...||.     |.|:||||||
Human   359 LAVTHAGVRLYFST--------------C----------PFRQPLARPNT-----LTLVHVRLPP 394

  Fly   402 GYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTY---LVESTALESLDG 463
            |::.::|..||.:||.|.|::|.:||..::..:.|:||.::..   .|.:   ::|:.....:||
Human   395 GFSASSTVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHD---TFPFQKPMMETQMTAGVDG 456

  Fly   464 VVWGLAEVHEPS-----TPQRK-------SPLNSARH---ARKVALLTNQGTHIIEVLKMVDVLR 513
            ..|.|:.:.|..     ||..|       ||:...:|   .:|..||:.||:.:...|:.||.||
Human   457 HSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLR 521

  Fly   514 QILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQK 578
            .:|:|..|...||::.||:...:.:||.|.|:||.|......:|:.||.:||..||||       
Human   522 HLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGE------- 579

  Fly   579 FLNASNRNMANQTLGPNTTNVRE--RQSMFMSTPMPNSVANSPVGFPGSQF-------------N 628
                  ..|...|..|..:||..  ...::.|:|:|   :.||  :|...|             :
Human   580 ------AQMRFPTTLPPPSNVGPILGSPVYSSSPVP---SGSP--YPNPSFLGTPSHGIQPPAMS 633

  Fly   629 QPISPIGNMQPPQVAVSNENSP-IVFSAKHDGLYMYVSRMLHSVWQMRCV--------NEQFCSN 684
            .|:..:||.......:|....| ||:|.||:|:.:|.||::.::|....|        |.:..:.
Human   634 TPVCALGNPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAI 698

  Fly   685 LSQSECALL---LSDLRSLRSFLEVHS------VHDISSTTRVSFDNHLDRTNSYNTIMMGNTLL 740
            .|...|.||   |.:|:.|:.||:.:|      :.:.::|.:|.     .|...:.....||   
Human   699 ESSVPCQLLESVLQELKGLQEFLDRNSQFAGGPLGNPNTTAKVQ-----QRLIGFMRPENGN--- 755

  Fly   741 PIPEQRVLS---EQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTC 802
            |...|:.|.   .:||:.|..||.|:...|:.:.:.::||.:|..|.|.:|..:|..|.|:.|..
Human   756 PQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKI 820

  Fly   803 STFRDLLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAK 867
            :||:||:|...|:...||.||||.|::|.|.|..:|.:|::.||.||..:|.:..||.|||..::
Human   821 TTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSR 885

  Fly   868 NCTSATEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFY 932
            ...:.||||.|||.:|...::.:..:.|.::|.|:....|:|||:|||...|.|.||:.:|:|||
Human   886 QVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFY 950

  Fly   933 NNGEPADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKN---- 993
            .:|||.:|..|...|..|:..||.:...|..:..:  :|...|..|:....|....|...|    
Human   951 KHGEPEEDIVGLQAFQERLNSYKCITDTLQELVNQ--SKAAPQSPSVPKKPGPPVLSSDPNMLSN 1013

  Fly   994 -GATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLI 1057
             .|.....:::..:.:.||.|..|.||.||:..|:..:||.|..|.|...|.|....:.:.|..:
Human  1014 EEAGHHFEQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYM 1078

  Fly  1058 DLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSL-SNGIFLKE 1121
            ||||:|||||...|.||.:|..||...|..|:|:||:||:.||::..::....||: ::|.||.|
Human  1079 DLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHE 1143

  Fly  1122 LEDKLDIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNC 1186
            ||:|:::||:|..:...:....|.......||.:|:..|.|||:||..||:||.|.||:|:|::|
Human  1144 LEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAECKLAIIHC 1208

  Fly  1187 SHHNDPLLIESVWGQIINSVVDKPGT--TSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEV 1249
            :.::||:|::::|..||...:....|  :|:|.:.|..||.:|.:.|..:...||..|:::.||.
Human  1209 AGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQ 1273

  Fly  1250 KACQLRFPEGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNA 1314
            :.|.|.:..|.|.:.:..:.:.:..|||.|.::....:..|.......||:..:..::....:|.
Human  1274 QVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENP 1338

  Fly  1315 QSIWYRSKRRIVGKAQDIVAGCL--------NICYQKPDTNRLQHSLKELQSQLQRL 1363
            ..:....:||......|.|.|.|        ::..|     .:..:.|.||::|:||
Human  1339 SQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQ-----AITGNFKSLQAKLERL 1390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup154NP_001285827.1 Nucleoporin_N 66..502 CDD:312364 179/464 (39%)
Nucleoporin_C <1018..1139 CDD:308677 49/121 (40%)
NUP155NP_705618.1 Nucleoporin_N 77..507 CDD:400932 177/461 (38%)
NUP170 89..1311 CDD:227624 440/1281 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 985..1012 6/28 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147845
Domainoid 1 1.000 322 1.000 Domainoid score I1227
eggNOG 1 0.900 - - E1_COG5308
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H43155
Inparanoid 1 1.050 742 1.000 Inparanoid score I590
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55643
OrthoDB 1 1.010 - - D140051at2759
OrthoFinder 1 1.000 - - FOG0004471
OrthoInspector 1 1.000 - - oto88639
orthoMCL 1 0.900 - - OOG6_102040
Panther 1 1.100 - - LDO PTHR10350
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R808
SonicParanoid 1 1.000 - - X3168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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