DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup154 and NUP170

DIOPT Version :9

Sequence 1:	NP_001285827.1	Gene:	Nup154 / 34527	FlyBaseID:	FBgn0021761	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_009474.1	Gene:	NUP170 / 852199	SGDID:	S000000175	Length:	1502	Species:	Saccharomyces cerevisiae

Alignment Length:	1515	Identity:	337/1515 - (22%)
Similarity:	597/1515 - (39%)	Gaps:	328/1515 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YNLERNKPGLLELTGVSQHGRATMSGLNDYDYQSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHF 86
            ||..|.|.||...|                     .|.|.|..:            ||:|||..|
Yeast   133 YNFSREKNGLGAFT---------------------PFEKQDVFN------------IPDEILHEF 164

  Fly    87 KHIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVK 151
            ...:....||:|||:.|.|:|||:::.:|..|...:....|.:.|.|..|.||:|||..||..||
Yeast   165 STSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVK 229

  Fly   152 YLLVLTTPIEVIVLGVTFGESSYNEMQLMNR--PVFVIGTDNVSISVIKGTDDGRIFLGGRDGCL 214
            :||:::|.:|:.:..::..::: ||:.:.|.  .|.|.|.|  .|.::.....||||..|:...|
Yeast   230 HLLLISTTMELFMFAISLDKAT-NELSVFNTHLSVPVQGID--VIDIVSHERSGRIFFAGQASGL 291

  Fly   215 --YEIYYQAESSWFGKRCKKINLSQGLVSYMVPS----------FLKV-----------FSEVDP 256
              :|::|.....||..:|.|:.|::..:..::|:          |::.           ||: :.
Yeast   292 NIWELHYSGSDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQ-ET 355

  Fly   257 IEHIEIDNSRKLLYVLTEKGVIEAW-----------DISTSYTTARRLGRITQNDITNQAVSLIT 310
            |..:.||..|.::|.|:.|..|.|:           .|..:| .:|.:|..|.     :|..::
Yeast   356 ITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAY-ISRIIGTTTA-----RAAPIL- 413

  Fly   311 TVDPSIFKSVKAICPLSADDADKLHLVAVTQCGVRLFF--STTSLNVKQQFGPAVPCSPGENTGF 373
              .|...|.|| |..::.::.:.|.|||:|..||||:|  |....|::.....::...|...|
Yeast   414 --GPKYLKIVK-ISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVT-- 473

  Fly   374 GQPAV--QPPLSPNAEAPKGLY----------------------LLHVR-----LPPGYTPNATT 409
              |.|  |..|....|..|..:                      ||...     :.||...:|..
Yeast   474 --PEVIQQELLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVI 536

  Fly   410 NKPKQVHAAHYTEGTMLMITTQ--------------QHEQDLLWSLSSAPSVNF-----TYLVES 455
            ...:|.|.....|.:.:..||.              ||:     ...|.|....     .|:..:
Yeast   537 KSSQQTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHK-----LFVSVPDYGILKTHGKYVENA 596

  Fly   456 TALESLDGV--VWGLAEVHEPST-PQ---RKSPLNSARHARKVALLTNQGTHIIEVLKMVDVLRQ 514
            |.||:...|  :..|:.:...:| ||   .:..........:||:||:....|.:.....::...
Yeast   597 TFLETAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFED 661

  Fly   515 ILLSCNGPHHEEVKMFFQSQNQREACVTALLLA----TSDTYRGSDVALWAAQAFMLYG--G--- 570
            ::        :....|..:....|||.|||.:.    .|:..|.:      |..|:..|  |
Yeast   662 LI--------DNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSN------ALTFLTMGIPGVVD 712

  Fly   571 -EPCYQHQKFLNASNRNMANQTLGPNTTNVRERQSMFMSTPMPNSVANSPVGFPGSQFNQPISPI 634
             :|.|........|:. ::..||...|||:::..:.| |.|.|   ||.      ..|
Yeast   713 IKPVYNRYSVSTVSSL-LSKPTLSTATTNLQQSITGF-SKPSP---ANK------EDF------- 759

  Fly   635 GNMQPPQVAVSNENSPIVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECALLLSD--- 696
                        :...::.|.:..|:.:.::|:|..:|. |.|...|..|...|...:..||
Yeast   760 ------------DLDDVILSPRFYGIALLITRLLRDIWG-RHVFMTFTDNRVTSHAFISSSDPIT 811

  Fly   697 --LRSLRSFLEVHSVHDISSTTRVSFD---NHLDRTNSYNT--IMMGNTLLPIPEQRVLS----- 749
              :.:|:|. |:....:|.|...:|.|   .:|...|..|.  |..|:::..|....||:
Yeast   812 PSINNLKSD-EISQNRNIISKVSISKDCIEYYLSSINILNEFFITYGDSISQISAPYVLANNSNG 875

  Fly   750 -------EQAQVEETRSLSALNLFVKHACEVISLWNILNSHS-----------FQLICVQLSPEH 796
                   |.|...|:.:::|:...|:...|.:|..|:|...|           |:.|...:|.:.
Yeast   876 RVIDKTEEVANQAESIAINAMIKMVQSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDV 940

  Fly   797 QKLLTCSTFRDLLITRSEVCAF---LIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYK 858
            ||.|....|:||.....:..:.   :::|:||..:...|.:...:..|:|.|.:.....|.:.::
Yeast   941 QKDLVKLDFKDLFAPNDKTKSLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFR 1005

  Fly   859 ATELLMNA---------------KNCTSATEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFF 908
            |.|.|..|               ||.|:..| :.:...::...|||...:         :|.:::
Yeast  1006 AIEHLRRAKEIGLRNYDSLNYHLKNATALLE-QIVDDLSIEKLKEAVSMM---------LSVNYY 1060

  Fly   909 EGVIELSAVCASKSDPEEVGVHFYNNGEPADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTH 973
            ...||.....|:..|..::...:..||...:|        .|..||.:..|:.|.::..:.....
Yeast  1061 PKSIEFLLNIANSMDKGKLACQYVANGFLEND--------DRKQYYDKRILVYDLVFDTLIKVDE 1117

  Fly   974 VQDKSINPLKGTAKASDAKNGATQTIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPS 1038
            :.:|. ...|...:.|.:.:...:...|.....||..|.|.|..:|:||::.:..::|||:..|.
Yeast  1118 LAEKK-QSSKTQNQISISNDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPF 1181

  Fly  1039 LGEFLRRSVSQNVDNVVLIDLLWKYYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMC 1103
            :..:|......::.   :.::||.||.:.|...::|.||..|| |.:.:|.|.:|||:|.||
Yeast  1182 ILPYLMEKAGSSLK---ISNILWVYYSRRSKFFESAEILYRLA-TSNFDITLFERIEFLSRA--- 1239

  Fly  1104 MRNG--NVGSSLSNGIFLKEL----EDKLDIARVQKSVLAAM-TELASDKLEAATAVKELNYALY 1161
              ||  |..|.||....:.:|    :|..::|.:|..:|:.: |:...|.......:|.|:..:.
Yeast  1240 --NGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKIL 1302

  Fly  1162 DITQLYQHFAEPFDLWECQLSILNCSHHNDPLLIESVWGQIINSV---VDKPGTTSERCNRLFTK 1223
            ..::|:..||.|....|..|.|...:...|..:|.:.|.::..|:   .:..|...:..|.:...
Yeast  1303 STSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLL 1367

  Fly  1224 IEILVREYGESGVCFPFAFLIRELEVKACQLRFPEGIVPEKLVSMNLDIELLLEYYSRMISMNER 1288
            ..:|:: .|::.....|.|.|.||....|.. |.|.:..|.:||.:    ::..:.:..:|.|:.
Yeast  1368 SNVLIK-IGKNVQDSEFIFPIFELFPIVCNF-FYETLPKEHIVSGS----IVSIFITAGVSFNKM 1426

  Fly  1289 VWANEGNEWHLIQSVIRVVSLLADNAQSI-----------WYRSKRRIVGKAQDIVA--GCLNIC 1340
                    :::::.:|..    :|:..|:           ||:|.|    |.:||::  ..:::.
Yeast  1427 --------YYILKELIET----SDSDNSVFNKEMTWLIHEWYKSDR----KFRDIISYNDIIHLK 1475

  Fly  1341 YQKPDTNRLQHSLKELQSQL 1360
            ..|.|.:.::..:|...:.|
Yeast  1476 EYKIDNDPIEKYVKNSGNNL 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup154	NP_001285827.1	Nucleoporin_N	66..502	CDD:312364	127/527 (24%)
Nup154	NP_001285827.1	Nucleoporin_C	<1018..1139	CDD:308677	38/126 (30%)
NUP170	NP_009474.1	NUP170	83..1496	CDD:227624	337/1515 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344025
Domainoid	1	1.000	129	1.000	Domainoid score	I1146
eggNOG	1	0.900	-	-		E1_COG5308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I677
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55643
OrthoFinder	1	1.000	-	-		FOG0004471
OrthoInspector	1	1.000	-	-		otm46552
orthoMCL	1	0.900	-	-		OOG6_102040
Panther	1	1.100	-	-	LDO	PTHR10350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R808
SonicParanoid	1	1.000	-	-		X3168
TreeFam	1	0.960	-	-
	14	13.790