Protein Alignment Nup154 and npp-8

DIOPT Version :9

• Sequence 1: NP_001285827.1
• Gene: Nup154 / 34527
• FlyBaseID: FBgn0021761
• Length: 1365
• Species: Drosophila melanogaster
• Sequence 2: NP_001343633.1
• Gene: npp-8 / 176966
• WormBaseID: WBGene00003794
• Length: 1340
• Species: Caenorhabditis elegans
• Alignment Length: 1398
• Identity: 336/1398 - (24%)
• Similarity: 590/1398 - (42%)
• Gaps: 175/1398 - (12%)

  Fly    37 VSQHGRATMSGLNDYDYQSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFKHIKCHCTMGLFPEI 101
            ::|||...:|||.:..|          .....:..:..:..||.|:.....:|....:||.|.:|
 Worm    38 LTQHGTTPVSGLGEKFY----------VKGAPEFVSTRRIPIPGELQMQMSNIHSEFSMGFFTQI 92

  Fly   102 GRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKYLLVLTTPIEVIVLG 166
            .|.|:.||:.:|:|.:....|:|::|.....|:.|.||..|||||..:::|.||:.|..::.:..
 Worm    93 SRVWVVIDNNLYMWNYETNDDLAFFDSSDAAILKVSLVNIKPGVFEPEIQYGLVVGTISDICLYP 157

  Fly   167 V-TFGESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGGRDGCLYEIYYQAESSWFGK-- 228
            | .|.|:..:.:.:.::..|.|..|..:::.|..|.:||:|... |..|:|..|:.::.|||.
 Worm   158 VFDFVENGASSISIDSKRCFKIALDGATVNDISYTSNGRVFYTA-DDQLFEFVYEKQNGWFGSTN 221

  Fly   229 -RCKKINLSQGLVSYMV--PSFLKVFSEVDPIEHIEIDNSRKLLYVLTEKGVIEAWDISTSYTTA 290
             :|:.:|.:..::..::  |.|   .|..:|::.|.||.||.::|:|...|.:..||:.......
 Worm   222 HKCRGVNQTASILGTLISLPFF---GSSKEPLDQITIDKSRNIMYLLGRAGTVSVWDLGADGAAC 283

  Fly   291 RRLGRITQNDITNQAVSLITTV--DPSIFKSVKAICPLSADDADKLHLVAVTQCGVRLFFSTTSL 353
            .:...:..:.|.::| .::|..  |.:.|.|:.:|..|.|..:..|:|||.|..||||:||.::
 Worm   284 AKFLSVPISKIAHEA-HILTQFGHDETSFHSITSIKALEASQSAALNLVATTAKGVRLYFSVST- 346

  Fly   354 NVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPPGYTP-NATTNKPKQVHA 417
                  ||....:...|:|......:|..|..   |:.|.:.|||..||.|| :...:.|..|..
 Worm   347 ------GPQSTMAMFNNSGTPNERNRPQTSVR---PQCLRVAHVRFAPGVTPASIYGDGPNGVSV 402

  Fly   418 AHYTEGTMLMITTQQHEQDLLWSLSS--APSVNFTYLVESTALESLDGVVWGLAEVHEPSTPQRK 480
            .:..|....|.|.   .::.:::.|:  .||..|  .||||....:.|.||.:..|.......|.
 Worm   403 VYADESICAMATA---NRNTIFAFSNFFYPSSQF--FVESTTECDISGHVWEIETVSRCKVKSRP 462

  Fly   481 SPLNSARHA------------------RKVALLTNQGTHIIEVLKMVDVLRQILLSCNGPHHEEV 527
            .|    ||.                  :|:.:.:|:|......:..||.||:.|.. .|......
 Worm   463 PP----RHLVDRVHPHSYFRSQLESGNQKLLVCSNEGVFEFTHVNAVDALREALFD-GGVEGNAT 522

  Fly   528 KMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPC-----YQHQKFLNASNRNM 587
            ...:|.....|....|..:.|||......:...|.|  :||..:..     .:.|:.|:.|
 Worm   523 LQLWQKLGSTEMLCLAFRILTSDAPIDERIRGKAEQ--ILYSLKEAPEIVENEQQRMLDQS---- 581

  Fly   588 ANQTLGPNTTNVRERQSMFMSTPMPNSV-------ANSPVGFPGSQFNQPISPIGNMQPPQVAVS 645
            ...:..||.:::.|.:.. |.||:.:|.       .|:....|.:.|:.|.||:.:|   .:|..
 Worm   582 TTTSWSPNDSSMAEWRHR-MKTPLLSSTPRTDGRNGNAGGAPPQAHFSSPFSPMLDM---SMASG 642

  Fly   646 NEN-----SPIVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECALLLSDLRSLRSFLE 705
            :.|     ||   |.:||.|:.|.||::..||     |:..|..|:..:..:.. :..|::|..|
 Worm   643 HHNGNMRMSP---SRRHDALFYYFSRLVAPVW-----NDTICEVLNGKQLTITF-EPESIQSLKE 698

  Fly   706 VHSVHDISSTTRVSFDNHL---DRTNSYNTIMMGNTLLPIPEQRVLSEQAQVEETRSLSALNLFV 767
                 :|....|:..|..|   ...|.|::.|...          |:.:|...|..||..|...:
 Worm   699 -----EIQKLARLMDDYRLVPMMEFNGYSSNMTDR----------LNHEATSLERHSLIGLRKLI 748

  Fly   768 KHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRDLLITRSEVCAFLIISLINLYLKDAA 832
            ....|.:|||.:...::...|...::|:.....:......|:...|.:.|.||.::|..:|.|.|
 Worm   749 DATLETLSLWLLAYEYNLTAISSGMNPQLLPNFSSRKLAHLVSDGSNLNAELIRAMIKYFLGDEA 813

  Fly   833 GVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEKEHMLRTTLHMCKEAAPTLPLHS 897
            |...:|::||:.|||||..:|.....|.|.|..|:.......:..::::.:.|.|::...:.|.|
 Worm   814 GTKILSESLRQLCPNLYSEDDACVTFAMEQLEAARKQGPGAARRRLVQSAVEMFKQSIGKVVLAS 878

  Fly   898 ICMQFI-SADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADDREGYTCFATRMAYYKEVQLML 961
            .|.|.. |.:.:|.::||..:.|:|.||:::.:..|.:|....|.|.......|...|:.:..:|
 Worm   879 TCQQLAESVEDYEPIVELCLLRAAKDDPKQLALLAYKHGRSGSDAEMLGAEKKREDCYRVITDVL 943

  Fly   962 DHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQTIPK--------IVAHTLKVKDPLIHITL 1018
            |.:                           ::.||..:|:        ::...|...|.|.|..:
 Worm   944 DKL---------------------------EDEATSEVPRDTAVNRDLMINAVLNSDDQLAHAAV 981

  Fly  1019 YEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWKYYEKNSHHSQAAHILDNLAMT 1083
            :.|||..:....:|....|.:..||.:.::.. ......||||::|||:.::.:||.:|..||..
 Worm   982 FRWLLTKNKTNVILQSKSPFIEFFLVQEINAG-RGQKYFDLLWRFYEKSGNYDKAARLLSKLAEN 1045

  Fly  1084 RSENINLEQRIEYLVRAVMCMRNGNVGSSLSNGIFLKELEDKLDIARVQKSVLAAMTELASDKLE 1148
            .:..:.|.||..||..|::|.::....:..:|   :.||.|:||:|.||..:..|:...||....
 Worm  1046 DNWKMGLTQRCAYLSHAILCAQSCKDSTVTTN---IDELRDRLDVANVQMRIKDALGCSASASAR 1107

  Fly  1149 AATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLLIESVWGQIINSVVDKPGTT 1213
            ....|::|:..:..:.:|...:..||.|.:.:||:|:|:.......|...|..||..........
 Worm  1108 NQEFVRKLDGPILSLQELLLQYVVPFKLHKIKLSLLHCAGMYVEKHIFETWEDIIQDEFTTAQDE 1172

  Fly  1214 SERCNRLFTKIEILVREYGESGVCFPFAFLIREL-----------EVKACQLRFPEGIVPEKLVS 1267
            ...|.:|...|..|...|.::.. ||..|:||.:           .|:..:...|....|.....
 Worm  1173 GTLCEQLSNTIGELFSVYRDTKY-FPREFVIRRILEIGSGGVIGESVQQQRHILPPSFYPLLCKK 1236

  Fly  1268 MNL-DIELLLEYYSRMISMNERVWA-NEGNEWHLIQSVIRVVSLLADNAQSIWYRSKRRIVGKAQ 1330
            :|| :.|.|........:..:..|. |...:.::.:.|:::...:....:::.....||  ..|:
 Worm  1237 INLSNCEFLRTASDEFRAGGDAWWTHNSRGQEYITKVVLKMARTVVRELENMPTAHSRR--STAR 1299

  Fly  1331 DIVAGCLNICYQKPDTNRLQHSLKELQSQLQRL 1363
            |.:...|....:..|.: ...||:.|.::|..|
 Worm  1300 DCLTHILPFIRRSCDVS-ASLSLQNLGTELTAL 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup154	NP_001285827.1	Nucleoporin_N	66..502	CDD:312364	123/464 (27%)
		Nucleoporin_C	<1018..1139	CDD:308677	35/120 (29%)
npp-8	NP_001343633.1	Nucleoporin_N	56..1208	CDD:331268	308/1242 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159802
Domainoid	1	1.000	164	1.000	Domainoid score	I2394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43155
Inparanoid	1	1.050	346	1.000	Inparanoid score	I1365
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55643
OrthoDB	1	1.010	-	-		D140051at2759
OrthoFinder	1	1.000	-	-		FOG0004471
OrthoInspector	1	1.000	-	-		oto18158
orthoMCL	1	0.900	-	-		OOG6_102040
Panther	1	1.100	-	-	LDO	PTHR10350
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910