DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup154 and Nup155

DIOPT Version :9

Sequence 1:	NP_001285827.1	Gene:	Nup154 / 34527	FlyBaseID:	FBgn0021761	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_573490.3	Gene:	Nup155 / 170762	MGIID:	2181182	Length:	1391	Species:	Mus musculus

Alignment Length:	1417	Identity:	475/1417 - (33%)
Similarity:	758/1417 - (53%)	Gaps:	141/1417 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ERNKPGLLELTGVSQHGRATMSGLNDYDY--QSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFK 87
            :|..|.|.||..||.....|:||::|.||  |....|.   ..:|.::.|:.:..:|.|::|.|.
Mouse    37 DRMYPDLSELLMVSAPNSPTVSGMSDMDYPLQGPGLLS---VPSLPEISTIRRVPLPPELVEQFG 98

  Fly    88 HIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKY 152
            |::|:|.||:||.|.||||||||:|::|.:....|:||:||||..|::|||||||.|:|...|::
Mouse    99 HMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRH 163

  Fly   153 LLVLTTPIEVIVLGVTF-----GESSYNE-----MQLMNRPVFVIGTDNVSISVIKGTDDGRIFL 207
            ||||.||:::::||:::     |....|:     |||:..|::.:.|||..:..|..||:|||||
Mouse   164 LLVLATPVDIVILGLSYANVQTGSGILNDSMCGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFL 228

  Fly   208 GGRDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLK-VFSEVDPIEHIEIDNSRKLLYV 271
            .|:||||||:.||||:.||.:||:|||.|:..:|::|||.|: .|||.|||..|||||||.:||.
Mouse   229 AGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPIVQIEIDNSRNILYT 293

  Fly   272 LTEKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHL 336
            .:|||||:.:|:........|:..::||.|.:.|.::..|:|.|:||.:..|..:.:.::....|
Mouse   294 RSEKGVIQVYDLGHDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIESSESLDCQL 358

  Fly   337 VAVTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPP 401
            :|||..||||:|||              |          |..||...||.     |.|:||||||
Mouse   359 LAVTHAGVRLYFST--------------C----------PFRQPLARPNT-----LTLVHVRLPP 394

  Fly   402 GYTPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTY---LVESTALESLDG 463
            |::.::|..||.:||.|.|::|.:||..::..:.|:||.::..   .|.:   ::|:.....:||
Mouse   395 GFSASSTVEKPSKVHKALYSKGILLMTASENEDNDILWCVNHD---TFPFQKPMMETQMTTRVDG 456

  Fly   464 VVWGLAEVHEPS-----TPQRK-------SPLNSARH---ARKVALLTNQGTHIIEVLKMVDVLR 513
            ..|.|:.:.|..     ||..|       ||:...:|   .:|..||:.||:.:...|:.||.||
Mouse   457 HSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLR 521

  Fly   514 QILLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQK 578
            .:|:|..|...||::.||:...:.:||.|.|:||.|......:|:.||.:||..||||
Mouse   522 HLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGE------- 579

  Fly   579 FLNASNRNMANQTLGPNTTNVRE--RQSMFMSTPMPNSVANSP------VGFP--GSQ---FNQP 630
               |..|..|  || |..:||..  ...|:.|:|:|   :.||      :|.|  |:|   .:.|
Mouse   580 ---AQMRFPA--TL-PTPSNVGPILGSPMYSSSPVP---SGSPYPNPSSLGTPSHGAQPPTMSTP 635

  Fly   631 ISPIGNMQPPQVAVSNENSP-IVFSAKHDGLYMYVSRMLHSVWQMRCVNEQFCSNLSQSECAL-- 692
            :..:|:......::|....| ||:|.||:|:.:|.||::.::|....|.|:...:.::...|:
Mouse   636 MCAVGSPAMQAASMSGLTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERVFKSSNREITAIES 700

  Fly   693 ---------LLSDLRSLRSFLEVHS------VHDISSTTRVSFDNHLDRTNSYNTIMMGNTLLPI 742
                     :|.:|:.|:.||:.:|      :.:.::|.||.     .|...:.....|||....
Mouse   701 SVPVQLLESVLQELKGLQEFLDRNSQFSGGPLGNPNTTARVQ-----QRLVGFMRPENGNTQQMQ 760

  Fly   743 PEQRVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRD 807
            .|.:...::||:.|..||.|:...|:.:.:.::||.:|..|.|.:|..:|..|.|:.|..:||:|
Mouse   761 QELQRKFQEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFSVIVGELQKEFQEQLKITTFKD 825

  Fly   808 LLITRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSA 872
            |:|...||...||.||||.|::|.|.|..:|.:|::.||.||..:|.|..||.|||..::...|.
Mouse   826 LVIRDKEVTGALIASLINCYIRDNAAVDGISLHLQDTCPLLYSTDDAVCSKANELLQRSRQVQSK 890

  Fly   873 TEKEHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEP 937
            ||:|.|||.:|...::.:..:.|.|:|.|:....|:|||:|||...|.|.||:.:|:|||.:|||
Mouse   891 TERERMLRESLKEYQKISNQVDLPSVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEP 955

  Fly   938 ADDREGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKN-----GATQ 997
            .:|..|...|..|:..||.:...|..:..:  :|...|..|:....|....|...|     .|..
Mouse   956 EEDVVGLQTFQERLNSYKCITDTLQELVNQ--SKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGH 1018

  Fly   998 TIPKIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWK 1062
            ...:::....:.||.|..|.||.||:..|:..:||.:..|.|...|.|....:.:.|..:||||:
Mouse  1019 HFEQMLKLAQRSKDELFSIALYNWLIQADLADKLLQIASPFLEPHLVRMARVDQNRVRYMDLLWR 1083

  Fly  1063 YYEKNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSL-SNGIFLKELEDKL 1126
            |||||...|.||.:|..||...|..|:|:||:||:.||::..::....||: ::|.||.|||:|:
Mouse  1084 YYEKNRSFSSAARVLSKLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKM 1148

  Fly  1127 DIARVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHND 1191
            ::||:|..:...:....|.......|:.:|:..|.|||:||..||:||.|.||:|::::|:.::|
Mouse  1149 EVARIQLQIQETLQRQYSHHSSVQDAISQLDSELMDITKLYGEFADPFKLAECKLAVIHCAGYSD 1213

  Fly  1192 PLLIESVWGQIINSVVDKPG--TTSERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQL 1254
            |:|:.::|..||...::...  ::|:|.:.|..|:.:|.:.|..:...||..|:::.||.:.|.|
Mouse  1214 PILVHTLWQDIIEKELNDSVALSSSDRMHALSLKLVLLGKIYAGTPRFFPLDFIVQFLEQQVCTL 1278

  Fly  1255 RFPEGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWY 1319
            .:..|.|.:.:..:.:.:..|||.|.::....:..|....:..||:..:..:::...:|...:..
Mouse  1279 NWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRVKSPLHLLDCIHVLLTRYVENPSLVLN 1343

  Fly  1320 RSKRRIVGKAQDIVAGCL--------NICYQKPDTNRLQHSLKELQSQLQRL 1363
            ..:||......|.|.|.|        ::..|     .:..:.|.||::|:||
Mouse  1344 CERRRFTNLCLDAVCGYLVELQSMSSSVAVQ-----AITGNFKSLQAKLERL 1390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup154	NP_001285827.1	Nucleoporin_N	66..502	CDD:312364	180/464 (39%)
Nup154	NP_001285827.1	Nucleoporin_C	<1018..1139	CDD:308677	48/121 (40%)
Nup155	NP_573490.3	Nucleoporin_N	77..507	CDD:285953	178/461 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..630		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1012		6/28 (21%)
		Nucleoporin_C	<1008..1213	CDD:281208	72/204 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837925
Domainoid	1	1.000	326	1.000	Domainoid score	I1182
eggNOG	1	0.900	-	-		E1_COG5308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43155
Inparanoid	1	1.050	749	1.000	Inparanoid score	I576
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55643
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004471
OrthoInspector	1	1.000	-	-		oto92204
orthoMCL	1	0.900	-	-		OOG6_102040
Panther	1	1.100	-	-	LDO	PTHR10350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R808
SonicParanoid	1	1.000	-	-		X3168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790