DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup154 and nup155

DIOPT Version :9

Sequence 1:	NP_001285827.1	Gene:	Nup154 / 34527	FlyBaseID:	FBgn0021761	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_002938230.2	Gene:	nup155 / 100379911	XenbaseID:	XB-GENE-973827	Length:	1388	Species:	Xenopus tropicalis

Alignment Length:	1414	Identity:	466/1414 - (32%)
Similarity:	741/1414 - (52%)	Gaps:	134/1414 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ERNKPGLLELTGVSQHGRATMSGLNDYDY--QSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFK 87
            :|..|.|.||..|..|...|:||:::.||  ||...|   ...:|.::..:.:..:|.|::|.|.
Frog    33 DRAYPDLSELLNVPVHTCPTISGVSEMDYPLQSPGLL---TIPSLPEISAIRRVPLPPELVEQFG 94

  Fly    88 HIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKY 152
            |::|:|.||:||||.||||||||:|::|.:....|:|||||||..|:||||||||.|:|...:::
Frog    95 HMQCNCMMGVFPEISRAWLTIDSDIFMWNYEDGGDLAYYDGLSETILSVGLVKPKAGIFQPHIRF 159

  Fly   153 LLVLTTPIEVIVLGVTF--------GESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGG 209
            ||||.||:::::||::|        .:|....|||:..|::.:.|||..:..|..||:|||||.|
Frog   160 LLVLATPVDIVILGLSFANLQPGNLNDSISGGMQLLPDPLYSLPTDNTYLLSITSTDNGRIFLSG 224

  Fly   210 RDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLK-VFSEVDPIEHIEIDNSRKLLYVLT 273
            :||||||:.||||:.||.:||:|||.|:..:|::|||.|: .|||.|||..|.|||||.:||..:
Frog   225 KDGCLYEVEYQAEAGWFSQRCRKINHSKSSLSFLVPSVLQFAFSEDDPIVQIAIDNSRNILYTRS 289

  Fly   274 EKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHLVA 338
            |||||:.:|:........|:..::||.:.:.|.::..|:|.::||.:..|..:...::...||:|
Frog   290 EKGVIQVYDLGVDGHGMSRVASVSQNSLVSAAGNIARTIDRNVFKPIIHISVIEMSESVNCHLLA 354

  Fly   339 VTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPPGY 403
            ||..||||:|||            ||        |.||..:|.:         |.|:|||||||:
Frog   355 VTHAGVRLYFST------------VP--------FKQPTARPSM---------LALVHVRLPPGF 390

  Fly   404 TPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTY---LVESTALESLDGVV 465
            :.::...||.:||.|.|..|.:||..::..:.|:||.::..   :|.:   ::|:.....:||..
Frog   391 SASSNVEKPSKVHRALYNSGVLLMAASENEDNDILWCINRD---SFPFQRPMMETQVTTQVDGHS 452

  Fly   466 WGLAEVHEPSTPQRKSPLNS------------ARH---ARKVALLTNQGTHIIEVLKMVDVLRQI 515
            |.|:.|.|....:..:|||.            .:|   .::..||:.||:||...|:.||.||.:
Frog   453 WALSAVDEQKADKIVTPLNKDLIPLTDSPVIIQQHMIPPKRFVLLSAQGSHIFYKLRPVDQLRHL 517

  Fly   516 LLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQKFL 580
            |:|.:|...||::.||:...:.:||.|.|:||.|......:|:.|||:||..||||...:.|..|
Frog   518 LVSNSGGDGEEIERFFKLHQENQACATCLILACSTAASDREVSAWAARAFFRYGGEAQLRVQSAL 582

  Fly   581 NASNRNMANQTLGP-NTTNVRERQSMFMSTPMPN-SVANSPV-GFPGSQFNQPISPIGNMQPPQV 642
            :...      .:|| ..:.:.....|.:.:|||| |...:|. |......:.|...:....|...
Frog   583 HQPG------NVGPIFGSPLPVASPMPVGSPMPNPSFLGTPTQGACPPNVSTPAYGVATPAPQPA 641

  Fly   643 AVSN-ENSPIVFSAKHDGLYMYVSRMLHSVW---------------QMRCVNEQFCSNLSQSECA 691
            ||.. ..:.|.||.||:|:.:|..|::.::|               ::..::......|.:|
Frog   642 AVPGMMGTEIAFSGKHNGICIYFCRIIGNIWDGSVAVENTFKSGNREVTAIDSSVTPQLLES--- 703

  Fly   692 LLLSDLRSLRSFLEVHSVHDISSTTRVSFDNHLDRTNSYNTIMMGNTLLPIPE-----------Q 745
             :|.:|:.|..||:.:|.....|....||....:|...    ::|   |..|:           |
Frog   704 -VLQELKGLLEFLDRYSQFTAGSLGNPSFGTPANRQQR----LVG---LGRPDSGSSQQAQQELQ 760

  Fly   746 RVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRDLLI 810
            |....:||:.|..||..::..|:..|:.::||.:|..|.|.||...|..|.|:.|..:||:||:|
Frog   761 RKYHTEAQLAEQLSLQGIHQLVRKMCQALALWKLLCEHQFSLIVSDLQKELQEQLKITTFKDLVI 825

  Fly   811 TRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEK 875
            ...|:...|..||||.|::|.|.|..||..|:|.||.||..:|.|..||.|||..:::..:..||
Frog   826 RDKELAGALTASLINCYIQDNASVDGVSYRLQEVCPLLYSTDDAVCSKANELLQRSRHVPNKLEK 890

  Fly   876 EHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADD 940
            |.|||.:|...::.:..:.|.::|.|:....|:|||:||....|.|.||:.:|:||:.||||.:|
Frog   891 ERMLRESLKEYQKISQQVDLPNVCAQYRQVRFYEGVVELCLTAAEKKDPQGLGLHFHKNGEPEED 955

  Fly   941 REGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQT-----IP 1000
            ..|...|..|:..||.:...|..:..:  :|...|..|:....|....|...|..:..     ..
Frog   956 VAGLQAFQERLNSYKCITDTLQELVNQ--SKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGIHFE 1018

  Fly  1001 KIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWKYYE 1065
            :::....:..|.|.:|.|:.||:..|:..:||::..|.|...|.|....:.:.|..:||||:|||
Frog  1019 QMLKLAQRSTDELFNIALFNWLIQADLTDKLLELNSPFLEPHLVRMAKLDQNKVRYMDLLWRYYE 1083

  Fly  1066 KNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSL-SNGIFLKELEDKLDIA 1129
            ||.:.|.||.::..||...|..|:|:||:||:.||::..::....|:| ::|.||.|||:||::|
Frog  1084 KNRNFSNAARVVAKLADMPSTEISLKQRLEYISRAILSAKSSTTMSTLAADGEFLHELEEKLEVA 1148

  Fly  1130 RVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLL 1194
            |:|..:...::...|.......||.:|:..|.|||:|:..:|:||.|.||:|:|::|:.|:||:|
Frog  1149 RIQLQIQETLSRQYSHHSAVGDAVSQLDSQLMDITKLFGQYADPFRLSECKLAIIHCAGHSDPIL 1213

  Fly  1195 IESVWGQIIN-SVVDKPGTTS-ERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQLRFP 1257
            ::::|.:||: .:.|..|.:| :|...|..|:..|.:.|..:...||..||::.||.:.|...:.
Frog  1214 VQTLWQEIIDKELSDSLGNSSVDRMQSLHLKMTSLGKIYASTPRYFPLEFLVKYLEQQVCNFSWD 1278

  Fly  1258 EGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWYRSK 1322
            .|.|...:..:|:.:..|||.|..:....:..|:......||::|:..::|........:....:
Frog  1279 AGFVTYTMQEINVPVPKLLEVYDHLFKARDPWWSRMKKPLHLLESIYLLLSGYVQEPSKVPSYER 1343

  Fly  1323 RRIVGKAQDIVAGCLNICY--------QKPDTNRLQHSLKELQSQLQRL 1363
            ||......|.::     ||        ..|.......:.|.||::|:||
Frog  1344 RRFTTLCLDAIS-----CYLVELQSMDPAPALLNTVSNFKSLQAKLERL 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup154	NP_001285827.1	Nucleoporin_N	66..502	CDD:312364	176/462 (38%)
Nup154	NP_001285827.1	Nucleoporin_C	<1018..1139	CDD:308677	47/121 (39%)
nup155	XP_002938230.2	NUP170	1..1280	CDD:227624	442/1300 (34%)
nup155	XP_002938230.2	Nucleoporin_N	73..501	CDD:370132	174/459 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43155
Inparanoid	1	1.050	747	1.000	Inparanoid score	I576
OMA	1	1.010	-	-		QHG55643
OrthoDB	1	1.010	-	-		D140051at2759
OrthoFinder	1	1.000	-	-		FOG0004471
OrthoInspector	1	1.000	-	-		oto102516
Panther	1	1.100	-	-	LDO	PTHR10350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R808
SonicParanoid	1	1.000	-	-		X3168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110