Protein Alignment Nup154 and nup155

DIOPT Version :10

• Sequence 1: NP_477287.1
• Gene: Nup154 / 34527
• FlyBaseID: FBgn0021761
• Length: 1365
• Species: Drosophila melanogaster
• Sequence 2: XP_002938230.2
• Gene: nup155 / 100379911
• XenbaseID: XB-GENE-973827
• Length: 1388
• Species: Xenopus tropicalis
• Alignment Length: 1414
• Identity: 466/1414 - (32%)
• Similarity: 741/1414 - (52%)
• Gaps: 134/1414 - (9%)

  Fly    25 ERNKPGLLELTGVSQHGRATMSGLNDYDY--QSLSFLKSDRTHNLQQMRTVTKSAIPNEILEHFK 87
            :|..|.|.||..|..|...|:||:::.||  ||...|   ...:|.::..:.:..:|.|::|.|.
 Frog    33 DRAYPDLSELLNVPVHTCPTISGVSEMDYPLQSPGLL---TIPSLPEISAIRRVPLPPELVEQFG 94

  Fly    88 HIKCHCTMGLFPEIGRAWLTIDSEIYIWTFNQTRDVAYYDGLSHLIVSVGLVKPKPGVFVQDVKY 152
            |::|:|.||:||||.||||||||:|::|.:....|:|||||||..|:||||||||.|:|...:::
 Frog    95 HMQCNCMMGVFPEISRAWLTIDSDIFMWNYEDGGDLAYYDGLSETILSVGLVKPKAGIFQPHIRF 159

  Fly   153 LLVLTTPIEVIVLGVTF--------GESSYNEMQLMNRPVFVIGTDNVSISVIKGTDDGRIFLGG 209
            ||||.||:::::||::|        .:|....|||:..|::.:.|||..:..|..||:|||||.|
 Frog   160 LLVLATPVDIVILGLSFANLQPGNLNDSISGGMQLLPDPLYSLPTDNTYLLSITSTDNGRIFLSG 224

  Fly   210 RDGCLYEIYYQAESSWFGKRCKKINLSQGLVSYMVPSFLK-VFSEVDPIEHIEIDNSRKLLYVLT 273
            :||||||:.||||:.||.:||:|||.|:..:|::|||.|: .|||.|||..|.|||||.:||..:
 Frog   225 KDGCLYEVEYQAEAGWFSQRCRKINHSKSSLSFLVPSVLQFAFSEDDPIVQIAIDNSRNILYTRS 289

  Fly   274 EKGVIEAWDISTSYTTARRLGRITQNDITNQAVSLITTVDPSIFKSVKAICPLSADDADKLHLVA 338
            |||||:.:|:........|:..::||.:.:.|.::..|:|.::||.:..|..:...::...||:|
 Frog   290 EKGVIQVYDLGVDGHGMSRVASVSQNSLVSAAGNIARTIDRNVFKPIIHISVIEMSESVNCHLLA 354

  Fly   339 VTQCGVRLFFSTTSLNVKQQFGPAVPCSPGENTGFGQPAVQPPLSPNAEAPKGLYLLHVRLPPGY 403
            ||..||||:|||            ||        |.||..:|.:         |.|:|||||||:
 Frog   355 VTHAGVRLYFST------------VP--------FKQPTARPSM---------LALVHVRLPPGF 390

  Fly   404 TPNATTNKPKQVHAAHYTEGTMLMITTQQHEQDLLWSLSSAPSVNFTY---LVESTALESLDGVV 465
            :.::...||.:||.|.|..|.:||..::..:.|:||.::..   :|.:   ::|:.....:||..
 Frog   391 SASSNVEKPSKVHRALYNSGVLLMAASENEDNDILWCINRD---SFPFQRPMMETQVTTQVDGHS 452

  Fly   466 WGLAEVHEPSTPQRKSPLNS------------ARH---ARKVALLTNQGTHIIEVLKMVDVLRQI 515
            |.|:.|.|....:..:|||.            .:|   .::..||:.||:||...|:.||.||.:
 Frog   453 WALSAVDEQKADKIVTPLNKDLIPLTDSPVIIQQHMIPPKRFVLLSAQGSHIFYKLRPVDQLRHL 517

  Fly   516 LLSCNGPHHEEVKMFFQSQNQREACVTALLLATSDTYRGSDVALWAAQAFMLYGGEPCYQHQKFL 580
            |:|.:|...||::.||:...:.:||.|.|:||.|......:|:.|||:||..||||...:.|..|
 Frog   518 LVSNSGGDGEEIERFFKLHQENQACATCLILACSTAASDREVSAWAARAFFRYGGEAQLRVQSAL 582

  Fly   581 NASNRNMANQTLGP-NTTNVRERQSMFMSTPMPN-SVANSPV-GFPGSQFNQPISPIGNMQPPQV 642
            :...      .:|| ..:.:.....|.:.:|||| |...:|. |......:.|...:....|...
 Frog   583 HQPG------NVGPIFGSPLPVASPMPVGSPMPNPSFLGTPTQGACPPNVSTPAYGVATPAPQPA 641

  Fly   643 AVSN-ENSPIVFSAKHDGLYMYVSRMLHSVW---------------QMRCVNEQFCSNLSQSECA 691
            ||.. ..:.|.||.||:|:.:|..|::.::|               ::..::......|.:|
 Frog   642 AVPGMMGTEIAFSGKHNGICIYFCRIIGNIWDGSVAVENTFKSGNREVTAIDSSVTPQLLES--- 703

  Fly   692 LLLSDLRSLRSFLEVHSVHDISSTTRVSFDNHLDRTNSYNTIMMGNTLLPIPE-----------Q 745
             :|.:|:.|..||:.:|.....|....||....:|...    ::|   |..|:           |
 Frog   704 -VLQELKGLLEFLDRYSQFTAGSLGNPSFGTPANRQQR----LVG---LGRPDSGSSQQAQQELQ 760

  Fly   746 RVLSEQAQVEETRSLSALNLFVKHACEVISLWNILNSHSFQLICVQLSPEHQKLLTCSTFRDLLI 810
            |....:||:.|..||..::..|:..|:.::||.:|..|.|.||...|..|.|:.|..:||:||:|
 Frog   761 RKYHTEAQLAEQLSLQGIHQLVRKMCQALALWKLLCEHQFSLIVSDLQKELQEQLKITTFKDLVI 825

  Fly   811 TRSEVCAFLIISLINLYLKDAAGVSEVSKNLRENCPNLYRHEDDVTYKATELLMNAKNCTSATEK 875
            ...|:...|..||||.|::|.|.|..||..|:|.||.||..:|.|..||.|||..:::..:..||
 Frog   826 RDKELAGALTASLINCYIQDNASVDGVSYRLQEVCPLLYSTDDAVCSKANELLQRSRHVPNKLEK 890

  Fly   876 EHMLRTTLHMCKEAAPTLPLHSICMQFISADFFEGVIELSAVCASKSDPEEVGVHFYNNGEPADD 940
            |.|||.:|...::.:..:.|.::|.|:....|:|||:||....|.|.||:.:|:||:.||||.:|
 Frog   891 ERMLRESLKEYQKISQQVDLPNVCAQYRQVRFYEGVVELCLTAAEKKDPQGLGLHFHKNGEPEED 955

  Fly   941 REGYTCFATRMAYYKEVQLMLDHIYQRVCNKTHVQDKSINPLKGTAKASDAKNGATQT-----IP 1000
            ..|...|..|:..||.:...|..:..:  :|...|..|:....|....|...|..:..     ..
 Frog   956 VAGLQAFQERLNSYKCITDTLQELVNQ--SKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGIHFE 1018

  Fly  1001 KIVAHTLKVKDPLIHITLYEWLLAHDMLKELLDVVEPSLGEFLRRSVSQNVDNVVLIDLLWKYYE 1065
            :::....:..|.|.:|.|:.||:..|:..:||::..|.|...|.|....:.:.|..:||||:|||
 Frog  1019 QMLKLAQRSTDELFNIALFNWLIQADLTDKLLELNSPFLEPHLVRMAKLDQNKVRYMDLLWRYYE 1083

  Fly  1066 KNSHHSQAAHILDNLAMTRSENINLEQRIEYLVRAVMCMRNGNVGSSL-SNGIFLKELEDKLDIA 1129
            ||.:.|.||.::..||...|..|:|:||:||:.||::..::....|:| ::|.||.|||:||::|
 Frog  1084 KNRNFSNAARVVAKLADMPSTEISLKQRLEYISRAILSAKSSTTMSTLAADGEFLHELEEKLEVA 1148

  Fly  1130 RVQKSVLAAMTELASDKLEAATAVKELNYALYDITQLYQHFAEPFDLWECQLSILNCSHHNDPLL 1194
            |:|..:...::...|.......||.:|:..|.|||:|:..:|:||.|.||:|:|::|:.|:||:|
 Frog  1149 RIQLQIQETLSRQYSHHSAVGDAVSQLDSQLMDITKLFGQYADPFRLSECKLAIIHCAGHSDPIL 1213

  Fly  1195 IESVWGQIIN-SVVDKPGTTS-ERCNRLFTKIEILVREYGESGVCFPFAFLIRELEVKACQLRFP 1257
            ::::|.:||: .:.|..|.:| :|...|..|:..|.:.|..:...||..||::.||.:.|...:.
 Frog  1214 VQTLWQEIIDKELSDSLGNSSVDRMQSLHLKMTSLGKIYASTPRYFPLEFLVKYLEQQVCNFSWD 1278

  Fly  1258 EGIVPEKLVSMNLDIELLLEYYSRMISMNERVWANEGNEWHLIQSVIRVVSLLADNAQSIWYRSK 1322
            .|.|...:..:|:.:..|||.|..:....:..|:......||::|:..::|........:....:
 Frog  1279 AGFVTYTMQEINVPVPKLLEVYDHLFKARDPWWSRMKKPLHLLESIYLLLSGYVQEPSKVPSYER 1343

  Fly  1323 RRIVGKAQDIVAGCLNICY--------QKPDTNRLQHSLKELQSQLQRL 1363
            ||......|.::     ||        ..|.......:.|.||::|:||
 Frog  1344 RRFTTLCLDAIS-----CYLVELQSMDPAPALLNTVSNFKSLQAKLERL 1387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup154	NP_477287.1	NUP170	32..1312	CDD:227624	451/1346 (34%)
		Nucleoporin_N	66..502	CDD:400932	176/462 (38%)
nup155	XP_002938230.2	NUP170	1..1280	CDD:227624	442/1300 (34%)
		Nucleoporin_N	73..504	CDD:400932	176/462 (38%)