Protein Alignment aub and PIWIL1

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_004755.2
• Gene: PIWIL1 / 9271
• HGNCID: 9007
• Length: 861
• Species: Homo sapiens
• Alignment Length: 882
• Identity: 326/882 - (36%)
• Similarity: 493/882 - (55%)
• Gaps: 54/882 - (6%)

  Fly    10 ARGRGRG------------RKPNNVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSI 62
            ||||.||            ::|..::......|:.|:........|  .:||.......|:....
Human     9 ARGRARGQETAQLVGSTASQQPGYIQPRPQPPPAEGELFGRGRQRG--TAGGTAKSQGLQISAGF 71

  Fly    63 EKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGM----TSKKGVVGTHITVQANYFKVLKR 123
            ::.||:          .||.  .||...||..:....:    .||.|..|..:.:..|:|::..|
Human    72 QELSLA----------ERGG--RRRDFHDLGVNTRQNLDHVKESKTGSSGIIVRLSTNHFRLTSR 124

  Fly   124 PNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGG-YIFDGTNMFCINQFKAVQDSPYVLELVTK 187
            |.|.:|||.:|:.|.:||.|||.:.|::|:.::|. :.||||.:|..   |.:|..  |.|:.:|
Human   125 PQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGKCHAFDGTILFLP---KRLQQK--VTEVFSK 184

  Fly   188 SRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLW 252
            :|.||::.|.|.....:..|.....|..|:|.||.::.::|:.:.|.||:|...|::.:.|:.:|
Human   185 TRNGEDVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPNDPIDIPSHRLVIW 249

  Fly   253 PGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDSDD--YQSTFKRAVMGMVILTDYNN 315
            ||:.|||.|:||.|:||:::.|||:|:||:.:.:.:....:::  :|....:.::|:|:||.|||
Human   250 PGFTTSILQYENSIMLCTDVSHKVLRSETVLDFMFNFYHQTEEHKFQEQVSKELIGLVVLTKYNN 314

  Fly   316 KTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN-DQA 378
            ||||:||:|:...|...||..|| |:|:::||:|:||..|.|||||:::|:|..:...||. ...
Human   315 KTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGP 379

  Fly   379 IMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIE 443
            .|:||||...||:||.||.||..::.::.||||.|::|...:......:.........|:.|.:.
Human   380 AMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKNDNVQRELRDWGLS 444

  Fly   444 LDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLRETQ 508
            .||.|:....|:|..|||..|.:........|||:.|.|...:.....::.|.:|...||.....
Human   445 FDSNLLSFSGRILQTEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAAN 509

  Fly   509 EFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSCIKK 573
            ..:|...:...:|.|.:...|..|: |||...|.:.:......|.|||:.::.|..::||..|||
Human   510 SLIQNLFKVTPAMGMQMRKAIMIEV-DDRTEAYLRVLQQKVTADTQIVVCLLSSNRKDKYDAIKK 573

  Fly   574 RTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVC 638
            ..|.|.|.|||.|..:.:..:|.    :|:||||:.:|||.|:.|..|:|.|||..:|.||.|..
Human   574 YLCTDCPTPSQCVVARTLGKQQT----VMAIATKIALQMNCKMGGELWRVDIPLKLVMIVGIDCY 634

  Fly   639 HSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERIL 703
            |......:|...|||::::..: |:||......:||||.:.:.|.:..|||::...:..:|.||:
Human   635 HDMTAGRRSIAGFVASINEGMT-RWFSRCIFQDRGQELVDGLKVCLQAALRAWNSCNEYMPSRII 698

  Fly   704 FFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF--TGHR--NP 764
            .:|||||||||..:||.||....|.|    ||.|:....|:|.|:|.||:|:|:|  :|.|  ||
Human   699 VYRDGVGDGQLKTLVNYEVPQFLDCL----KSIGRGYNPRLTVIVVKKRVNTRFFAQSGGRLQNP 759

  Fly   765 VPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSG 829
            :||||:|..:|.||.||||:||||||.|:||||.||||.||.||..|.:|.|:||:.|:|||:.|
Human   760 LPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDHIQRLTYKLCHIYYNWPG 824

  Fly   830 TIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            .|||||.|.|||||||||.:||:|.|:..|.|:||:|
Human   825 VIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	50/123 (41%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	178/452 (39%)
PIWIL1	NP_004755.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		12/56 (21%)
		GAGE	16..106	CDD:461753	17/103 (17%)
		D-box. /evidence=ECO:0000269|PubMed:28552346	217..224		2/6 (33%)
		PAZ	277..415	CDD:198017	56/137 (41%)
		Required for binding 2'-O-methylated 3'-end of piRNAs. /evidence=ECO:0000269|PubMed:21193640	316..318		1/1 (100%)
		Piwi_piwi-like_Euk	401..844	CDD:240016	178/452 (39%)
		MID region. /evidence=ECO:0000250|UniProtKB:Q9JMB7	479..615		42/140 (30%)