DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and AGO3

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_174414.1	Gene:	AGO3 / 840017	AraportID:	AT1G31290	Length:	1194	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	219/962 - (22%)
Similarity:	373/962 - (38%)	Gaps:	185/962 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GRG----RGRKPNNVEA---NRGF------APSLGQKSDPSHSEGNQASGGNGGG---------G 54
            |||    ||:..:.:.:   .||.      ..::.|.|.......:.|:||.|.|         .
plant   232 GRGGVGDRGQSQSGLSSGHFGRGTQLQQPQPQAVSQSSSQGQVSQSFATGGVGLGAWARKPQLFS 296

  Fly    55 DAQVGPSIEKSSLSAVQMHKSEGD----PRGSVRGRRLITDLVYSRPP--GMTSKKGVVGTHITV 113
            |:.|.||  .||.:.|..|.:.|.    |:.|...::    ....||.  |....|||    |.:
plant   297 DSTVLPS--SSSSNVVASHTASGSQVMTPKPSSSDKK----EPVKRPDKGGNIKVKGV----INL 351

  Fly   114 QANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGGYIFDGTNMF--CINQFKAVQ 176
            ..|:|:|.......|..|.||...:..:.::.|..|    .::...:|...|.|  .:..:...:
plant   352 SVNHFRVSFSTESVIRHYDVDIKGENSSKKISRFEL----AMVKEKLFKDNNDFPNAMTAYDGQK 412

  Fly   177 DSPYVLELVTKS-----------RAGENIEIKIKAVGSVQSTDAEQF--QVLNLILRRAMEGLDL 228
            :....:||.|.|           ..|.:....||.|..::..|.:.:  .....|.|..::|:|:
plant   413 NIFSAVELPTGSFKVDFSETEEIMRGRSYTFIIKQVKELKLLDLQAYIDGRSTFIPRDVLQGMDV 477

  Fly   229 KL----------VSRYYYDPQAKINL-------ENFRMQLWPGYQTSIRQHENDILLCSEICHKV 276
            .:          |.:.::..:.:|:.       :.|...|.|..| .:....|..||.......|
plant   478 VMKEHPSKRMITVGKRFFSTRLEIDFGYGVGAAKGFHHTLKPTVQ-GLSLCLNSSLLAFRKAISV 541

  Fly   277 MRTETLY----NIL-------SDAIRD------SDDYQSTFKR-AVMGMVILTDYNNKTYRIDDV 323
            :....||    ||.       .|.:::      :.|::.|.:: .:||   |:..:.|..:.|.:
plant   542 IEYLKLYFGWRNIRQFKNCRPDDVVQELIGLKVTVDHRKTKQKFIIMG---LSKDDTKDIKFDFI 603

  Fly   324 DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIPELARA 388
            |.......:      :||.|:|:|::|.   ||:....:......|  :|..:...|....|..
plant   604 DHAGNQPPR------KISIVEYFKEKYG---RDIDHKDIPCLNLGK--KGRENFVPMEFCNLVE- 656

  Fly   389 TGMTDAMRADFRTLRA-MSEHTRLNPDRRIERLRMFNKRLKSC--KQSVETLKSWNIELDSALVE 450
             |........:|...| :.|.:.:.|.:|:|.:   ||.:||.  .:..:.:.::.:.:|..:..
plant   657 -GQIFPKEKLYRDSAAWLKELSLVTPQQRLENI---NKMIKSSDGPRGGDIIGNFGLRVDPNMTT 717

  Fly   451 IPARVL--PPEKILFGNQKIFVCDARADWTNE----------FRTCSMFKNVHINRWYVI--TPS 501
            :..|||  |..|:         .|.|.:..:|          ..|..:.|...|..|.|:  |.|
plant   718 VEGRVLEAPTLKL---------TDRRGNPIHEKLMSESNQWNLTTKGVTKGSIIKHWAVLDFTAS 773

  Fly   502 RNLRETQE--FVQMCIRTASSMKMN-----ICNPIYEEIPDDRNG---TYSQAIDNAAAND---- 552
            .:|::...  ||...|.....:.|.     :|.....|...|.|.   .....||.|:.|.
plant   774 ESLKKKMPGYFVNKLIERCKGLGMQMEAPIVCKTSSMETLYDGNALEELLRSVIDEASHNHGGAC 838

  Fly   553 PQIVMVVMRSPNEEKYSCIKKRTCVDRPVPSQ-VVTLKVIAPRQQKPTGLMSIATKVVIQMNAKL 616
            |.:|:..| :...:.|..:|........:.:| .:|:..|.........|.::|.|:    |||:
plant   839 PTLVLCAM-TGKHDGYKTLKWIAETKLGLVTQCFLTISAIKGETVSDQYLANLALKI----NAKV 898

  Fly   617 MGAPWQVVIPLHG-------LMTVGFDVCH--SPKNKNKSYGAFVATMDQKESFRYFSTVNEHIK 672
            .|...::|..:..       :|.:|.||.|  :..|.:.|..|.|.|::..|:.||.:.|.....
plant   899 GGTNVELVDNIFSFFKKEDKVMFIGADVNHPAAHDNMSPSIVAVVGTLNWPEANRYAARVKAQSH 963

  Fly   673 GQELSEQMSVNMAC--ALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKS 735
            .:|  |.......|  .:.::.:.....|.:|:.|||||.|||...|:|.|:..:||    ::..
plant   964 RKE--EIQGFGETCWELIEAHSQAPEKRPNKIVIFRDGVSDGQFDMVLNVELQNVKD----VFAK 1022

  Fly   736 AGKQEGCRMTFIIVSKRINSRYFTG-------HRNPVP-GTVVDDVITLPERYDFFLVSQAVRIG 792
            .|...  ::|.|:..||..:|:|..       .:..|| |||||..|..|..|||:|.||...||
plant  1023 VGYNP--QITVIVAQKRHQTRFFPATTSKDGRAKGNVPSGTVVDTTIIHPFEYDFYLCSQHGAIG 1085

  Fly   793 TVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLA 844
            |..||.|.|:||.:|.|::::|.|.:.:...:...:..:.:.....||.|.|
plant  1086 TSKPTHYYVLSDEIGFNSNQIQKLIFDLCFTFTRCTKPVALVPPVSYADKAA 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	24/128 (19%)
		PAZ_piwi_like	272..392	CDD:239211	27/137 (20%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	126/496 (25%)
AGO3	NP_174414.1	PLN03202	318..1138	CDD:215631	196/874 (22%)
		ArgoN	336..479	CDD:293095	32/150 (21%)
		PAZ	560..663	CDD:280352	22/118 (19%)
		Piwi_ago-like	703..1144	CDD:240015	116/457 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.890