DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and Piwil4

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_008764202.1	Gene:	Piwil4 / 689972	RGDID:	1311015	Length:	848	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	284/830 - (34%)
Similarity:	450/830 - (54%)	Gaps:	46/830 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EKSSLSAV--QMHK---SEGDPRGSV-----RGRRLITDLVYSRPPGMT----SKKGVVGTHITV 113
            |.||.::|  |.|:   |.||.|.::     .||:...||.......:|    ||.|..|..:.:
  Rat    39 EASSRTSVISQPHELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQL 103

  Fly   114 QANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILG--GYIFDGTNMFCINQFKAVQ 176
            ..|.|.:....:|.:|||.|.::||:.:.|||.:.||.| .||.  ...||||::|...:.
  Rat   104 ATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNH-SILSDKAKAFDGTSLFLSEKL---- 163

  Fly   177 DSPYVLELVTKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAK 241
             ...|.||.::::.||.::|.:.....:........|..|:|.|:..:.|.:..:.|.||.|...
  Rat   164 -DHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEP 227

  Fly   242 INLENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSD-AIR-DSDDYQSTFKRAV 304
            :.:..:::.||||:..|:.:.|:.:|..:::.:||:|.||:...::| .:| |...:..|..:.:
  Rat   228 VEIPQYKLSLWPGFAISVSRFESKLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQL 292

  Fly   305 MGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTD 368
            :|:::||.||||||||||:|:...|...|:..|| |.:||||||::|:|.:.||.||:::|....
  Rat   293 VGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKR 357

  Fly   369 KNIRGGNDQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQS 433
            :.......|.:.:||||...||:|....:|||.::|::|.|||:|..|.::|......::..:.:
  Rat   358 RRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVT 422

  Fly   434 VETLKSWNIELDSALVEIPARVLPPEKILFGN---QKIFVCDARADWTNEFRTCSMFKNVHINRW 495
            ...|::|.:...|.| .:..||:|.||||..:   |..|.    |||:.:.|:|.:..:..:|.|
  Rat   423 RFELETWGLHFGSQL-SLTGRVVPSEKILLQDHTCQPAFA----ADWSKDMRSCKVLSSEPLNTW 482

  Fly   496 YVITPSRNLRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVM 560
            .::..||.....:.|:....|...|...::.:|...:: |:....:.:||......|.|:||.::
  Rat   483 LIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKV-DENPAAFLRAIQLHVNPDVQLVMCIL 546

  Fly   561 RSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVI 625
            .|..:..|..||:....|.|||||.|..:.:    .|...::|:|||:.:||..||.|..|.|.|
  Rat   547 PSNQKNYYDSIKRYLSSDCPVPSQCVLTRTL----NKQGMMLSVATKIAMQMTCKLGGELWAVEI 607

  Fly   626 PLHGLMTVGFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRS 690
            ||..||.||.|:|....:|:.:...|||:::.:.: |:||.........::::.:.|.|..||..
  Rat   608 PLKSLMVVGIDICRDALSKDVAVVGFVASINSRIT-RWFSRCVLQRTAADIADCLKVCMTGALNK 671

  Fly   691 YQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINS 755
            :.:.:..||.||:.:|||||:|||..|:..||..|   |..:.:.......||::.::|.||...
  Rat   672 WYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQL---LSSVTECGSDARSCRLSVVVVRKRCLL 733

  Fly   756 RYF--TGH--RNPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQML 816
            |.|  :||  :||..|||||...|.||.|||:|.||....||||||.||||.|:..|..|.:|.|
  Rat   734 RLFAESGHTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRL 798

  Fly   817 SYKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            ::|:.|:|||:.|.|.|||.|.|||||.||||:||::.||..|.|:|::|
  Rat   799 TFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	32/115 (28%)
		PAZ_piwi_like	272..392	CDD:239211	48/122 (39%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	161/455 (35%)
Piwil4	XP_008764202.1	ArgoN	95..205	CDD:293095	32/115 (28%)
		PAZ_piwi_like	265..381	CDD:239211	45/115 (39%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	161/455 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340830
Domainoid	1	1.000	130	1.000	Domainoid score	I5077
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720