DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment aub and Piwil1

DIOPT Version :9

Sequence 1:NP_476734.1 Gene:aub / 34524 FlyBaseID:FBgn0000146 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_067286.1 Gene:Piwil1 / 57749 MGIID:1928897 Length:862 Species:Mus musculus


Alignment Length:884 Identity:325/884 - (36%)
Similarity:498/884 - (56%) Gaps:55/884 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ARGRGRGRKPNNVE-------ANRGFAPSLGQKSDPSHSE----GNQAS---GGNGGGGDAQVGP 60
            ||.|||.|....|:       ...|:.|...|:| |:..:    |.|..   |......:.|:..
Mouse     7 ARARGRARGQETVQHVGAAASQQPGYIPPRPQQS-PTEGDLVGRGRQRGMVVGATSKSQELQISA 70

  Fly    61 SIEKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGM----TSKKGVVGTHITVQANYFKVL 121
            ..::.||:          .||.  .||...||..:....:    .||.|..|..:.:..|:|::.
Mouse    71 GFQELSLA----------ERGG--RRRDFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRLT 123

  Fly   122 KRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGG-YIFDGTNMFCINQFKAVQDSPYVLELV 185
            .||.|.:|||.:|:.|.:||.|||.:.|::|:.::|. :.||||.:|..   |.:|..  |.|:.
Mouse   124 SRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGRCHAFDGTILFLP---KRLQHK--VTEVF 183

  Fly   186 TKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQ 250
            :::|.||::.|.|.....:..|.....|..|:|.||.::.::|:.:.|.||:|...|::.|.|:.
Mouse   184 SQTRNGEHVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRLV 248

  Fly   251 LWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDSDD--YQSTFKRAVMGMVILTDY 313
            :|||:.|||.|:||:|:||:::.|||:|:||:.:.:.:..:.:::  :|....:.::|:::||.|
Mouse   249 IWPGFTTSILQYENNIMLCTDVSHKVLRSETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKY 313

  Fly   314 NNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN-D 376
            ||||||:||:|:...|...||..|| |:|:::||:|:||..|.|||||:::|:|..:...||. .
Mouse   314 NNKTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLP 378

  Fly   377 QAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWN 441
            ...|:||||...||:||.||.||..::.::.||||.|::|...:......:.........|:.|.
Mouse   379 GPAMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDWG 443

  Fly   442 IELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLRE 506
            :..||.|:....|:|..|||..|.:........|||:.|.|...:.....::.|.:|...||...
Mouse   444 LSFDSNLLSFSGRILQSEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEA 508

  Fly   507 TQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSCI 571
            ....:|...:...:|.:.:...|..|: |||...|.:|:.....:|.|||:.::.|..::||..|
Mouse   509 ANSLIQNLFKVTPAMGIQMKKAIMIEV-DDRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDAI 572

  Fly   572 KKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFD 636
            ||..|.|.|.|||.|..:.:..:|.    :|:||||:.:|||.|:.|..|:|.:||...|.||.|
Mouse   573 KKYLCTDCPTPSQCVVARTLGKQQT----VMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGID 633

  Fly   637 VCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPER 701
            ..|......:|...|||::::..: |:||......:||||.:.:.|.:..|||::...:..:|.|
Mouse   634 CYHDTTAGRRSIAGFVASINEGMT-RWFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPSR 697

  Fly   702 ILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF--TGHR-- 762
            ::.:|||||||||..:||.||....|.|    ||.|:....|:|.|:|.||:|:|:|  :|.|  
Mouse   698 VIVYRDGVGDGQLKTLVNYEVPQFLDCL----KSVGRGYNPRLTVIVVKKRVNARFFAQSGGRLQ 758

  Fly   763 NPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNY 827
            ||:||||:|..:|.||.||||:||||||.|:||||.||||.|:.||..|.:|.|:||:.|:|||:
Mouse   759 NPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYNW 823

  Fly   828 SGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            .|.|||||.|.|||||||||.:||:|.|:..|.|:||:|
Mouse   824 PGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aubNP_476734.1 ArgoN 105..219 CDD:293095 37/114 (32%)
PAZ_piwi_like 272..392 CDD:239211 49/123 (40%)
Piwi_piwi-like_Euk 400..849 CDD:240016 175/452 (39%)
Piwil1NP_067286.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 12/41 (29%)
GAGE 16..107 CDD:399085 20/103 (19%)
D-box. /evidence=ECO:0000269|PubMed:23328397 218..225 2/6 (33%)
PAZ 278..416 CDD:198017 55/137 (40%)
Required for binding 2'-O-methylated 3'-end of piRNAs. /evidence=ECO:0000269|PubMed:21237665 317..319 1/1 (100%)
Piwi_piwi-like_Euk 402..845 CDD:240016 175/452 (39%)
MID region. /evidence=ECO:0000305|PubMed:24757166 480..616 42/140 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837116
Domainoid 1 1.000 113 1.000 Domainoid score I6108
eggNOG 1 0.900 - - E1_KOG1042
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37963
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54391
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003636
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100694
Panther 1 1.100 - - LDO PTHR22891
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3665
SonicParanoid 1 1.000 - - X548
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.740

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