Protein Alignment aub and Piwil2

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001351250.1
• Gene: Piwil2 / 57746
• MGIID: 1930036
• Length: 1042
• Species: Mus musculus
• Alignment Length: 933
• Identity: 291/933 - (31%)
• Similarity: 479/933 - (51%)
• Gaps: 115/933 - (12%)

  Fly     4 PPN----PVIARG-RGRGRKPNNV-------------------------EANRGFAPSLGQ-KSD 37
            ||:    |.:.|| .|||...|.|                         ||:.|::..||: .|:
Mouse   155 PPSKREVPPLGRGVLGRGLSANMVRKDREEPRSSLPDPSVLAAGDSKLAEASVGWSRMLGRGSSE 219

  Fly    38 PSHSEGNQASGGNGGGGD---------AQVGPSI-EKSSLSAVQMHKSEGDPRGSVRGRRLITDL 92
            .|.....:|:...|.|.|         |:..|.: :..:||...:|.:  ||
Mouse   220 VSLLPLGRAASSIGRGMDKPPSAFGLTARDPPRLPQPPALSPTSLHSA--DP------------- 269

  Fly    93 VYSRPPGMTS---------KKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSF 148
                ||.:|.         |:|..||..::..|..|: :..|..:|||.|.|:|.||...:|...
Mouse   270 ----PPVLTMERKEKELLVKQGSKGTPQSLGLNLIKI-QCHNEAVYQYHVTFSPSVECKSMRFGM 329

  Fly   149 LYEHKGILGGY-IFDGTNMFCINQFKAVQDSPYVLELVTKSRAGE-NIEIKIKAVGSVQSTDAEQ 211
            |.:|:.:.|.. .|||:.::.  ..|..|    |:||.::.:..: .|.|||:....::......
Mouse   330 LKDHQSVTGNVTAFDGSILYL--PVKLQQ----VVELKSQRKTDDAEISIKIQLTKILEPCSDLC 388

  Fly   212 FQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSEICHKV 276
            ....|::.||.|:.||:|||.|.:|||.:.:.|:..|:|:||||..|||:.:..:.|.:::.|||
Mouse   389 IPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKV 453

  Fly   277 MRTETLYNILSDAI--RDSDDYQSTFKRAVMGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG- 338
            :|.:::.::: .||  ::.:.:|....:.::|.:::|.|||:||||||||:..||...|..:||
Mouse   454 IRNDSVLDVM-HAIYQQNKEHFQDECSKLLVGSIVITRYNNRTYRIDDVDWNKTPKDSFVMSDGK 517

  Fly   339 EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKN------IRGGNDQAIMIIPELARATGMTDAMRA 397
            ||::::||.|.|.|.:::..|||::.||:::.      ::|    .|:::|||:..||:.:.|:.
Mouse   518 EITFLEYYSKNYGITVKEDDQPLLIHRPSERQNNHGMLLKG----EILLLPELSFMTGIPEKMKK 578

  Fly   398 DFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKIL 462
            |||.::.:::...|:|.:....|....:|:...:.:...|..|.:.|...:.:|..|:||.|:|.
Mouse   579 DFRAMKDLTQQINLSPKQHHGALECLLQRISQNETASNELTRWGLSLHKDVHKIEGRLLPMERIN 643

  Fly   463 FGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLRETQEFVQMCIRTASSMKMNICN 527
            ..|.. ||.....:|..|....:....:.::.|.:..|.|.:.:.:|.|.|..:.|..:.|.|..
Mouse   644 LRNTS-FVTSEDLNWVKEVTRDASILTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRISP 707

  Fly   528 PIYEEIPDDRNGTYSQAIDNAAANDPQIVMVV--MRSPNEEKYSCIKKRTCVDRPVPSQVVTLKV 590
            |.:.|:.|||..||.:.|.:....:.:|.|||  :....::.|..|||..||..||||||:.::.
Mouse   708 PAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDLYGAIKKLCCVQSPVPSQVINVRT 772

  Fly   591 IAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKSYGAFVATM 655
            |.    :||.|.|:|.|:::|||.||.|..|.|.|||..||.:|.||.|.|....:|...|||::
Mouse   773 IG----QPTRLRSVAQKILLQMNCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASI 833

  Fly   656 DQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNS 720
            :...: :::|.|...:..||:.:.:.:.:..:|:.|.|.:..|||:|:.:||||.||||..|.|.
Mouse   834 NLTLT-KWYSRVVFQMPHQEIVDSLKLCLVGSLKKYYEVNHCLPEKIVVYRDGVSDGQLKTVANY 897

  Fly   721 EVNTLK---DRLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRN----PVPGTVVDDVITLPE 778
            |:..|:   :..|..:.        :|...:|.|:|::..:....:    |.||||||..||..|
Mouse   898 EIPQLQKCFEAFDNYHP--------KMVVFVVQKKISTNLYLAAPDHFVTPSPGTVVDHTITSCE 954

  Fly   779 RYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKL 843
            ..||:|::..||.|...||.|..:.:...|:.|.:|.|::|:.|||:|:.|||||||.|.|||||
Mouse   955 WVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKL 1019

  Fly   844 AFLVAESINRAPSAGLQNQLYFL 866
            |||..:.::..|:..|...|:||
Mouse  1020 AFLSGQILHHEPAIQLCGNLFFL 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	44/128 (34%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	153/457 (33%)
Piwil2	NP_001351250.1	PHA03247	<73..271	CDD:223021	28/134 (21%)
		ArgoL1	408..455	CDD:462567	19/46 (41%)
		PAZ_piwi_like	456..573	CDD:239211	40/121 (33%)
		Piwi_piwi-like_Euk	581..1025	CDD:240016	153/457 (33%)