DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and piwil2

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001352553.1	Gene:	piwil2 / 572134	ZFINID:	ZDB-GENE-060526-345	Length:	1046	Species:	Danio rerio

Alignment Length:	894	Identity:	282/894 - (31%)
Similarity:	462/894 - (51%)	Gaps:	67/894 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLPPNPVIARGRGRGRKPNNVEA---------NRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQ 57
            :|.|.|.|.   |....|...|.         .|||. ..|:.:.|      ..:.|.|..|...
Zfish   191 DLQPKPTII---GASLTPEREEVRSEESISFLGRGFT-GFGRAAMP------HMTVGRGPIGPLS 245

  Fly    58 VGPSIEK--SSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGMTSKKGVVGTHITVQANYFKV 120
            ..||:..  |.:||  ...||..|.......::...:...:.|  ..|.|..|:.|.:.:||..:
Zfish   246 PSPSVAAPFSLISA--SSASEDAPVAPGTPPKVEVKIETVKEP--LQKIGTKGSPIPIGSNYIPI 306

  Fly   121 LKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGGYI-FDGTNMFCINQFKAVQDSPYVLEL 184
            ..: |..::||.|.|||:||:..:|...:.||:...|..: |||:.::.          |..||.
Zfish   307 CCK-NDAVFQYHVTFTPNVESLSMRFGMMKEHRPTTGEVVAFDGSILYL----------PKRLEE 360

  Fly   185 VTKSRA-----GENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINL 244
            |...:|     .:.|:|||:....:..:........|::|||.|:.|.||||.|.:|||.|.:.|
Zfish   361 VVHLKAERKTDNQEIDIKIQLTKILPPSSDLCIPFYNVVLRRVMKILGLKLVGRNHYDPNAVVIL 425

  Fly   245 ENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDS-DDYQSTFKRAVMGMV 308
            ...|:|:||||.|||:..:..:.|..::.|||:|.:::.::::...:.| :.:|....:..:|.:
Zfish   426 GKHRLQVWPGYSTSIKHTDGGLYLVVDVSHKVLRNDSVLDVMNLIYQGSRESFQDECTKEFVGSI 490

  Fly   309 ILTDYNNKTYRIDDVDFQSTPLCKFKTNDGEI-SYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIR 372
            ::|.|||:||||||:::..:|...|...||.: ::||||:|.|.|.|::|.|||::.||.:::..
Zfish   491 VITRYNNRTYRIDDIEWSKSPKDTFTLADGSVTTFVDYYRKNYGITIKELDQPLLIHRPKERSRP 555

  Fly   373 GGN--DQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVE 435
            ||.  ...|:::|||:..||:.:.||.|||.::.::.|..:...:..:.|:.....:.|..:::.
Zfish   556 GGKVITGEILLLPELSFMTGIPEKMRKDFRAMKDLTMHINVGAQQHTQSLKQLLHNINSNNEALS 620

  Fly   436 TLKSWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITP 500
            .|..|.:.:...::....|.||.|.|.. :...||.....||:.|.........|.:|.|.|..|
Zfish   621 ELGRWGLSISQEILVTQGRTLPSETICL-HSASFVTSPAVDWSRELVRDPSISTVPLNCWAVFYP 684

  Fly   501 SRNLRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDP--QIVMVVMRSP 563
            .|...:.:|.|....|.|..|.|.:..||..|:.|||..|:.::|.:...::|  |:|:.:|...
Zfish   685 RRATDQAEELVTTFSRVAGPMGMRVERPIRVELRDDRTETFVKSIHSQLTSEPRVQLVVCIMTGN 749

  Fly   564 NEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLH 628
            .::.||.|||..|:..|||||.:.::.|:    :|..|.|:|.|:::|:|.||.|..|.|.:||.
Zfish   750 RDDLYSAIKKLCCIQSPVPSQAINVRTIS----QPQKLRSVAQKILLQINCKLGGELWTVNVPLK 810

  Fly   629 GLMTVGFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQE 693
            .||.:|.||.|....|::|...|||:::...: :::|.|...:..:|:.....|.:..||:.|.|
Zfish   811 YLMVIGVDVHHDTSKKSRSVMGFVASLNSMLT-KWYSRVTFQMPNEEIINGFRVCLLAALQKYYE 874

  Fly   694 QHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEI--YKSAGKQEGCRMTFIIVSKRINS- 755
            .:.:.||:|:.:||||.||||..|.:.|:..:....:.|  |:.       ::.||:|.|||::
Zfish   875 VNHAFPEKIVIYRDGVSDGQLKTVEHYEIPQILKCFETIPNYEP-------KLAFIVVQKRISTT 932

  Fly   756 --RYFTGH-RNPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLS 817
              .|.:.| ..|.||||:|..:|..:..||:|::.::|.|...||.|..:.:...|..|.||.|:
Zfish   933 LYSYGSDHFGTPSPGTVLDHTVTNRDWVDFYLMAHSIRQGCGLPTHYITVYNTANLTPDHLQRLT 997

  Fly   818 YKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            :||.|:|:|:.|||||||.|.||||||||..:.::..|:..|..:|:||
Zfish   998 FKMCHLYWNWPGTIRVPAPCKYAHKLAFLSGQYLHSEPAIQLSEKLFFL 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	31/119 (26%)
		PAZ_piwi_like	272..392	CDD:239211	43/123 (35%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	149/456 (33%)
piwil2	NP_001352553.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		ArgoL1	412..457	CDD:312283	18/44 (41%)
		PAZ	461..598	CDD:198017	45/136 (33%)
		Piwi_piwi-like_Euk	585..1029	CDD:240016	149/456 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580669
Domainoid	1	1.000	97	1.000	Domainoid score	I7193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760