Protein Alignment aub and ago2

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_009292643.1
• Gene: ago2 / 570630
• ZFINID: ZDB-GENE-110606-6
• Length: 898
• Species: Danio rerio
• Alignment Length: 859
• Identity: 192/859 - (22%)
• Similarity: 363/859 - (42%)
• Gaps: 172/859 - (20%)

  Fly   105 GVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEH------KGILGGY--IF 161
            |.:|..|.:|||:|: ::.|...:|.|.:|..|:....|:.|. :.||      ..|.|..  ::
Zfish    46 GTMGRTIKLQANFFE-MEIPKLEVYHYEIDIKPEKCPRRVNRE-IVEHMVQHFKTQIFGDRKPVY 108

  Fly   162 DG-TNMFCINQFKAVQDSPYVLEL-VTKSRAGENIEIKI--------------KAV-GSVQSTDA 209
            || .|::........:|.   :|| ||....|::...|:              :|: |.:.:...
Zfish   109 DGRKNLYTAMPLPIGRDK---VELEVTIPGEGKDRSFKVAIKWMSCVSLQALHEALSGRLPNIPF 170

  Fly   210 EQFQVLNLILRRAMEGLDLKLVSRYYYDP-QAKINLENFRMQLWPGYQTSIRQHENDILLCSEIC 273
            |..|.|::::|. :..:....|.|.::.| :...|......::|.|:..|:|.....::|..::.
Zfish   171 ETIQALDVVMRH-LPSMRYTPVGRSFFTPSEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVS 234

  Fly   274 ----HKVMRT-ETLYNILS-DAIRD-----SDDYQSTFKRAVMGMVILTDY---NNKTYRIDDV- 323
                :|.... |.:..:|. .:|.:     :|..:..|.:.:.|:.:...:   ..:.||:.:|
Zfish   235 ATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVT 299

  Fly   324 ----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIP- 383
                ..|:.||.:......|.:...|:|.:|.:::|....|.         ::.|.:|....:|
Zfish   300 RRPASHQTFPLQQENGQTIECTVAQYFKDKYKLVLRYPHLPC---------LQVGQEQKHTYLPL 355

  Fly   384 ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVET-LKSWNIELD 445
            |:.........::  .|.:|...:....|..|||:.|    .:|.::|...:.:. ::.:.:.:.
Zfish   356 EVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQDE----ISKLMRSANFNTDPYVREFGVMVR 416

  Fly   446 SALVEIPARVLPPEKILFGNQKIFVCDARAD-WTN------------------------EFRTCS 485
            ..:.|:..|||....||:|. ::.:..|:.. |.|                        :.|...
Zfish   417 DDMTEVNGRVLQAPSILYGG-RVRISSAQLSIWLNPCLIWSCLWLFQNKAIATPVQGVWDMRNKQ 480

  Fly   486 MFKNVHINRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI------CNPIYEEIPDDRNGT 540
            ....:.|..|.:  ..|.|...|  .:.|.....:.:....|.|      |.
Zfish   481 FHTGIEIKVWAIACFAPQRQCTELLLKAFTDQLRKISRDAGMPIQGQPCFCK------------- 532

  Fly   541 YSQAIDNAAANDP------------QIVMVVM--RSPNEEKYSCIKKRTCVDRPVPSQVVTLKVI 591
            |:|..|:.   :|            |:|:|::  ::|   .|:.:|:.......:.:|.|.:|.:
Zfish   533 YAQGADSV---EPMFKHLKYTYQGLQLVVVILPGKTP---VYAEVKRVGDTVLGMATQCVQVKNV 591

  Fly   592 APRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHSP--KNKNKS 647
              ::..|..|.::..|:    |.||.|.. .:::|       ...::.:|.||.|.|  ..|..|
Zfish   592 --QKTTPQTLSNLCLKI----NVKLGGVN-NILLPQGRPLVFQQPVIFLGADVTHPPAGDGKKPS 649

  Fly   648 YGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDG 712
            ..|.|.:||...| ||.:||......|::.:.::..:...|..:.:..|..|.||:::|||:.:|
Zfish   650 IAAVVGSMDAHPS-RYCATVRVQQHRQDIIQDLATMVRELLIQFYKSTRFKPTRIIYYRDGISEG 713

  Fly   713 QLYQVVNSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRNP-------VP- 766
            |..||:..|:..:::   :|::.|     |.|  :||::|.||.::|.|...||.       :|
Zfish   714 QFNQVLQHELLAIREACIKLEKDY-----QPG--ITFVVVQKRHHTRLFCMDRNERVGKSGNIPA 771

  Fly   767 GTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTI 831
            ||.||..||.|..:||:|.|.|...||..|:.|:|:.|:....:|:||:|:|::.|.|...:.::
Zfish   772 GTTVDTKITHPFEFDFYLCSHAGIQGTSRPSHYHVLWDDNHFTSDELQVLTYQLCHTYVRCTRSV 836

  Fly   832 RVPAVCHYAHKLAF 845
            .:||..:|||.:||
Zfish   837 SIPAPAYYAHLVAF 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	23/139 (17%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	125/516 (24%)
ago2	XP_009292643.1	ArgoN	106..180	CDD:465134	15/76 (20%)
		ArgoL1	190..240	CDD:462567	9/49 (18%)
		PAZ_argonaute_like	241..361	CDD:239212	22/128 (17%)
		Piwi_ago-like	406..856	CDD:240015	117/480 (24%)