DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aub and PIWIL2

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001129193.1	Gene:	PIWIL2 / 55124	HGNCID:	17644	Length:	973	Species:	Homo sapiens

Alignment Length:	927	Identity:	291/927 - (31%)
Similarity:	477/927 - (51%)	Gaps:	113/927 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIARGR---GRGRKPNNVEANR-------------------------GFAPSLGQ-KSDPSHSEG 43
            ::..||   |||...|.|..:|                         |::.:||: .||.|....
Human    92 MLPSGRGILGRGLSANLVRKDREELSPTFWDPKVLAAGDSKMAETSVGWSRTLGRGSSDASLLPL 156

  Fly    44 NQASGG-------------NGGGGDAQVG--PSIEKSSLSAVQMHKSEGDPRGSVRGRRLITDLV 93
            .:|:||             ....|..|:.  |::.:|.|     |..:          |.:...|
Human   157 GRAAGGISREVDKPPCTFSTPSRGPPQLSSPPALPQSPL-----HSPD----------RPLVLTV 206

  Fly    94 YSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGG 158
            ..:...:..|:|..||..::..|..|: :..|..:|||.|.|:|:||...:|...|.:|:.:.|.
Human   207 EHKEKELIVKQGSKGTPQSLGLNLVKI-QCHNEAVYQYHVTFSPNVECKSMRFGMLKDHQAVTGN 270

  Fly   159 Y-IFDGTNMFCINQFKAVQDSPYVLELVTKSRAGENIEIKIKAVGSVQSTDAEQ------FQVLN 216
            . .|||:.::.  ..|..|    ||||.:: |..::.||.||    :|.|...:      ....|
Human   271 VTAFDGSILYL--PVKLQQ----VLELKSQ-RKTDSAEISIK----IQMTKILEPCSDLCIPFYN 324

  Fly   217 LILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTET 281
            ::.||.|:.||:|||.|.:|||.:.:.|:..|:|:||||..|||:.:..:.|.:::.|||:|.:.
Human   325 VVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVIRNDC 389

  Fly   282 LYNILSDAI--RDSDDYQSTFKRAVMGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG-EISYV 343
            :.::: .||  ::.:.:|....:.::|.:::|.|||:||||||||:..||...|..:|| ||:::
Human   390 VLDVM-HAIYQQNKEHFQDECTKLLVGNIVITRYNNRTYRIDDVDWNKTPKDSFTMSDGKEITFL 453

  Fly   344 DYYKKRYNIIIRDLKQPLVMSRPTDKN------IRGGNDQAIMIIPELARATGMTDAMRADFRTL 402
            :||.|.|.|.:::..|||::.||:::.      ::|    .|:::|||:..||:.:.|:.|||.:
Human   454 EYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKG----EILLLPELSFMTGIPEKMKKDFRAM 514

  Fly   403 RAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQK 467
            :.:::...|:|.:....|....:|:...:.:...|..|.:.|...:.:|..||||.|:|...|..
Human   515 KDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLKNTS 579

  Fly   468 IFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLRETQEFVQMCIRTASSMKMNICNPIYEE 532
             |:.....:|..|.........:.::.|.:..|.|.:.:.:|.|.|..:.|..:.|.:..|.:.|
Human   580 -FITSQELNWVKEVTRDPSILTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSPPAWVE 643

  Fly   533 IPDDRNGTYSQAIDNAAANDPQIVMVV--MRSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQ 595
            :.|||..||.:.|.:....:.:|.|||  :..|.::.|..|||..||..|||||||.::.|.
Human   644 LKDDRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIG--- 705

  Fly   596 QKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKSYGAFVATMDQKES 660
             :||.|.|:|.|:::|:|.||.|..|.|.|||..||.:|.||.|.|....:|...|||:::...:
Human   706 -QPTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLT 769

  Fly   661 FRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTL 725
             :::|.|...:..||:.:.:.:.:..:|:.:.|.:..|||:|:.:||||.||||..|.|.|:..|
Human   770 -KWYSRVVFQMPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQL 833

  Fly   726 KDRLD--EIYKSAGKQEGCRMTFIIVSKRINSR-YFTGHRN---PVPGTVVDDVITLPERYDFFL 784
            :...:  |.|:.       :|...:|.|:|::. |....:|   |.||||||..||..|..||:|
Human   834 QKCFEAFENYQP-------KMVVFVVQKKISTNLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYL 891

  Fly   785 VSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAE 849
            ::..||.|...||.|..:.:...|:.|.:|.|::|:.|||:|:.|||||||.|.||||||||...
Human   892 LAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGH 956

  Fly   850 SINRAPSAGLQNQLYFL 866
            .::..|:..|...|:||
Human   957 ILHHEPAIQLCENLFFL 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	35/120 (29%)
		PAZ_piwi_like	272..392	CDD:239211	44/128 (34%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	155/456 (34%)
PIWIL2	NP_001129193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..65
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..199		7/41 (17%)
		ArgoL1	339..386	CDD:312283	19/46 (41%)
		PAZ_piwi_like	387..504	CDD:239211	40/121 (33%)
		Piwi_piwi-like_Euk	512..956	CDD:240016	155/456 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147176
Domainoid	1	1.000	113	1.000	Domainoid score	I6122
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3665
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.650