DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment aub and ago2

DIOPT Version :10

Sequence 1:NP_476734.1 Gene:aub / 34524 FlyBaseID:FBgn0000146 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_001004877.1 Gene:ago2 / 448205 XenbaseID:XB-GENE-1001916 Length:871 Species:Xenopus tropicalis


Alignment Length:853 Identity:198/853 - (23%)
Similarity:362/853 - (42%) Gaps:153/853 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 YSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEH-----K 153
            |:..|......|..|..|.:|||:|: :..|...||.|.:|..|:....|:.|. :.||     |
 Frog    23 YTFKPPPRPDFGTSGRTIKLQANFFE-MDIPKIEIYHYEIDIKPEKCPRRVNRE-IVEHMVQHFK 85

  Fly   154 GILGG---YIFDG-TNMFCINQFKAVQDSPYVLELVTKSRAGENI-EIKIKAV------------ 201
            ..:.|   .:||| .|::........:|....||:.......:.| ::.||.:            
 Frog    86 AQIFGDRKPVFDGRKNLYTAMPLPIARDKQVELEVTLPGEGKDRIFKVAIKWMACVSLQALHDAL 150

  Fly   202 -GSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYD-PQAKINLENFRMQLWPGYQTSIRQHEN 264
             |.:.|...|..|.|::::|. :..:....|.|.::. .:...|......::|.|:..|:|....
 Frog   151 SGRLPSVPFETIQALDVVMRH-LPSMRYTPVGRSFFTASEGCANPLGGGREVWFGFHQSVRPSLW 214

  Fly   265 DILLCSEIC----HKVMRT-ETLYNILS-DAIRD-----SDDYQSTFKRAVMGMVILTDY---NN 315
            .::|..::.    :|.... |.:..:|. .:|.:     :|..:..|.:.:.|:.:...:   ..
 Frog   215 KMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMK 279

  Fly   316 KTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN 375
            :.||:.:|     ..|:.||.:......|.:...|:|.|:.:::|....|.         ::.|.
 Frog   280 RKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPC---------LQVGQ 335

  Fly   376 DQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVET- 436
            :|....:| |:.........::  .|.:|...:....|..|||:.|    .:|.::|...:.:. 
 Frog   336 EQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEE----ISKLMRSASFNTDPF 396

  Fly   437 LKSWNIELDSALVEIPARVLPPEKILFGNQ----------KIFVCDARADWTNEFRTCSMFKNVH 491
            ::.:.|.:...:.::..|||.|..||:|.:          |......:..|  :.|.......:.
 Frog   397 VREFGIMVKDDMTDVTGRVLQPPSILYGGRVWEEPNAPLNKAIATPVQGVW--DMRNKQFHTGIE 459

  Fly   492 INRWYV--ITPSRNLRET--QEFVQMCIRTASSMKMNI------CNPIYEEIPDDRNGTYSQAID 546
            |..|.:  ..|.|...|.  :.|.:...:.:....|.|      |.             |:|..|
 Frog   460 IKVWAIACFAPQRQCTEVHLKTFTEQLRKISRDAGMPIQGQPCFCK-------------YAQGAD 511

  Fly   547 NAAANDP------------QIVMVVM--RSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQK 597
            :.   :|            |:|:|::  ::|   .|:.:|:.......:.:|.|.:|.:  ::..
 Frog   512 SV---EPMFRHLKNTYTGLQLVVVILPGKTP---VYAEVKRVGDTVLGMATQCVQMKNV--QRTT 568

  Fly   598 PTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHSP--KNKNKSYGAFVA 653
            |..|.::..|:    |.||.|.. .:::|       ...::.:|.||.|.|  ..|..|..|.|.
 Frog   569 PQTLSNLCLKI----NVKLGGVN-NILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVG 628

  Fly   654 TMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVV 718
            :||...: ||.:||......||:.:.:|..:...|..:.:..|..|.||:|:||||.:||..||:
 Frog   629 SMDAHPN-RYCATVRVQQHRQEIIQDLSAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVL 692

  Fly   719 NSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRNP-------VP-GTVVDD 772
            :.|:..:::   :|::.|     |.|  :|||:|.||.::|.|...||.       :| ||.||.
 Frog   693 HHELLAIREACIKLEKDY-----QPG--ITFIVVQKRHHTRLFCTDRNERVGKSGNIPAGTTVDT 750

  Fly   773 VITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVC 837
            .||.|..:||:|.|.|...||..|:.|:|:.|:...::|:||:|:|::.|.|...:.::.:||..
 Frog   751 KITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPA 815

  Fly   838 HYAHKLAF 845
            :|||.:||
 Frog   816 YYAHLVAF 823

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
aubNP_476734.1 PAZ_piwi_like 272..392 CDD:239211 23/139 (17%)
Piwi_piwi-like_Euk 400..849 CDD:240016 129/501 (26%)
ago2NP_001004877.1 ArgoN 83..169 CDD:465134 17/85 (20%)
ArgoL1 179..229 CDD:462567 8/49 (16%)
PAZ_argonaute_like 230..350 CDD:239212 22/128 (17%)
Interaction with guide RNA. /evidence=ECO:0000250 314..319 2/4 (50%)
Piwi_ago-like 395..829 CDD:240015 121/465 (26%)
Interaction with guide RNA. /evidence=ECO:0000250 536..578 8/46 (17%)
Interaction with GW182 family members. /evidence=ECO:0000255 599..602 0/2 (0%)
Interaction with GW182 family members. /evidence=ECO:0000255 662..672 2/9 (22%)