DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and PIWIL3

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001008496.2	Gene:	PIWIL3 / 440822	HGNCID:	18443	Length:	882	Species:	Homo sapiens

Alignment Length:	906	Identity:	291/906 - (32%)
Similarity:	472/906 - (52%)	Gaps:	81/906 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ARGRGRGRKPNNVEANRG-FAPSLGQKSDPSHSEG-----------------NQASGGNGGGGDA 56
            ||||.|.|:....||..| .||......:|...:.                 ..|.||.|||..:
Human     9 ARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQS 73

  Fly    57 Q----VGPSIEKSSLSAVQMHKSEGDPRGSVRGRRL---ITDLVYSRPPGM----TSKKGVVGTH 110
            |    .||.        ..:|.:      .::.||:   ..|||.:....|    .||.|..||.
Human    74 QGVKEPGPE--------AGLHTA------PLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTV 124

  Fly   111 ITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILG-GYIFDGTNMFCINQFKA 174
            :.:.||:|:|:.||.|..|:|.||:.||:|...||...|.:|:...| .:||||.::......|.
Human   125 VQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKE 189

  Fly   175 VQDSPYVLELVTKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQ 239
            .:     :|.::.::....::|.::....:..|..:..:..|::.||..:.||.:.|.|.||..:
Human   190 RR-----VEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKK 249

  Fly   240 AKINL--ENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNIL--SDAIRDSDDYQSTF 300
            ..|.|  ....:::|.||.||:.|:||.|.||:::.||::|.||.|:.:  :.|...:.:.:...
Human   250 KAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEV 314

  Fly   301 KRAVMGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMS 364
            ...::|.::||.|||||||:||:|::..|...|..:|| :|:|:|||::::..|:...||||::|
Human   315 TNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVS 379

  Fly   365 RPT-DKNIRGGNDQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLK 428
            :.. .|.:.|...:.|::||:|...||:||.:..|:..::.:::||||:|.||...|:.|...|:
Human   380 QGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQ 444

  Fly   429 SCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHIN 493
            ..|:..|.|:.|:::.|:..:.:|.|||....|:.| :::...:::.||:.|.|...:...:.::
Human   445 DNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQG-RRMVKANSQGDWSREIRELPLLNAMPLH 508

  Fly   494 RWYVITPSRNLRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVM- 557
            .|.::....:.||............:.|.:.:......|:..|.| :|...:........|:.|
Human   509 SWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDAN-SYIDTLRKYTRPTLQMGMS 572

  Fly   558 ------VVMRSPNEEK--YSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNA 614
                  |:...||::|  |..||:..|...|:|||.|..|.:...|.:     :|.||:..|||.
Human   573 CLLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQAR-----TIVTKIAQQMNC 632

  Fly   615 KLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQ 679
            |:.||.|:|...:...|.||.|..|...|:.||...|||:.: .|..:::|.......|:||.::
Human   633 KMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTN-AELTKWYSQCVIQKTGEELVKE 696

  Fly   680 MSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRM 744
            :.:.:..||..:.:...|:|..::.:|||||||||..:::.|...:...|..|     ......:
Human   697 LEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTI-----SPNNFTL 756

  Fly   745 TFIIVSKRINSRYFTGH----RNPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDN 805
            .||:|.||||:|:|..|    :||.||||:|..:|..|.||||:|||:|:.|||:||.||||.|.
Human   757 AFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDT 821

  Fly   806 MGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            :||:.|.:|.|:|.:.|||||..|.|||||.||||||||:||.:||::.|:..|..:|::|
Human   822 IGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	31/114 (27%)
		PAZ_piwi_like	272..392	CDD:239211	43/123 (35%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	157/461 (34%)
PIWIL3	NP_001008496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		22/95 (23%)
		ArgoN	119..225	CDD:293095	30/110 (27%)
		PAZ_piwi_like	278..408	CDD:239211	46/129 (36%)
		Piwi_piwi-like_Euk	416..865	CDD:240016	157/461 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147173
Domainoid	1	1.000	116	1.000	Domainoid score	I6014
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720