DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and Piwil1

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_017453899.1	Gene:	Piwil1 / 363912	RGDID:	1306980	Length:	863	Species:	Rattus norvegicus

Alignment Length:	885	Identity:	325/885 - (36%)
Similarity:	498/885 - (56%)	Gaps:	56/885 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ARGRGRGRKPNNVE--------ANRGFAPSLGQKSDPSHSE----GNQAS---GGNGGGGDAQVG 59
            ||.|||.|....|:        ...|:.|...|:| |:..:    |.|..   |......:.|:.
  Rat     7 ARARGRARGQETVQHVGAAAQSQQPGYIPPRPQQS-PTEGDLVGRGRQRGMVVGATSKSQELQIS 70

  Fly    60 PSIEKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGM----TSKKGVVGTHITVQANYFKV 120
            ...::.||:          .||.  .||...||..:....:    .||.|..|..:.:..|:|::
  Rat    71 AGFQELSLA----------ERGG--RRRDFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRL 123

  Fly   121 LKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGG-YIFDGTNMFCINQFKAVQDSPYVLEL 184
            ..||.|.:|||.:|:.|.:||.|||.:.|::|:.::|. :.||||.:|..   |.:|..  |.|:
  Rat   124 TSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGRCHAFDGTILFLP---KRLQHK--VTEV 183

  Fly   185 VTKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRM 249
            .:::|.||::.|.|.....:..|.....|..|:|.||.::.::|:.:.|.||:|...|::.|.|:
  Rat   184 FSQTRNGEHVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRL 248

  Fly   250 QLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDSDD--YQSTFKRAVMGMVILTD 312
            .:|||:.|||.|:||:|:||:::.|||:|:||:.:.:.:..:.:::  :|....:.::|:::||.
  Rat   249 VIWPGFTTSILQYENNIMLCTDVSHKVLRSETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTK 313

  Fly   313 YNNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN- 375
            |||||||:||:|:...|...||..|| |:|:::||:|:||..|.|||||:::|:|..:...||.
  Rat   314 YNNKTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTL 378

  Fly   376 DQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSW 440
            ....|:||||...||:||.||.||..::.::.||||.|::|...:......:.........|:.|
  Rat   379 PGPAMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDW 443

  Fly   441 NIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLR 505
            .:..||.|:....|:|..|||..|.:........|||:.|.|...:.....::.|.:|...||..
  Rat   444 GLSFDSNLLSFSGRILQSEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYE 508

  Fly   506 ETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSC 570
            .....:|...:...:|.:.:...|..|: |||...|.:|:.....:|.|||:.::.|..::||..
  Rat   509 AANSLIQNLFKVTPAMGIQMKKAIMIEV-DDRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDA 572

  Fly   571 IKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGF 635
            |||..|.|.|.|||.|..:.:..:|.    :|:||||:.:|||.|:.|..|:|.:||...|.||.
  Rat   573 IKKYLCTDCPTPSQCVVARTLGKQQT----VMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGI 633

  Fly   636 DVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPE 700
            |..|......:|...|||::::..: |:||......:||||.:.:.|.:..|||::...:..:|.
  Rat   634 DCYHDTTAGRRSIAGFVASINEGMT-RWFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPS 697

  Fly   701 RILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF--TGHR- 762
            |::.:|||||||||..:||.||....|.|    ||.|:....|:|.|:|.||:|:|:|  :|.|
  Rat   698 RVIVYRDGVGDGQLKTLVNYEVPQFLDCL----KSVGRGYNPRLTVIVVKKRVNARFFAQSGGRL 758

  Fly   763 -NPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYN 826
             ||:||||:|..:|.||.||||:||||||.|:||||.||||.|:.||..|.:|.|:||:.|:|||
  Rat   759 QNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYN 823

  Fly   827 YSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            :.|.|||||.|.|||||||||.:||:|.|:..|.|:||:|
  Rat   824 WPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	37/114 (32%)
		PAZ_piwi_like	272..392	CDD:239211	49/123 (40%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	175/452 (39%)
Piwil1	XP_017453899.1	GAGE	16..108	CDD:399085	20/104 (19%)
		PAZ	279..417	CDD:198017	55/137 (40%)
		Piwi_piwi-like_Euk	403..846	CDD:240016	175/452 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340827
Domainoid	1	1.000	113	1.000	Domainoid score	I5968
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37963
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	LDO	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.720