DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and piwi

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	376/883 - (42%)
Similarity:	537/883 - (60%)	Gaps:	71/883 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RGRGRGRKPNNVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKS 75
            :|||| |:|.|             :.|.|.|.|:         ||   ||.::      |....|
  Fly     5 QGRGR-RRPLN-------------EDDSSTSRGS---------GD---GPRVK------VFRGSS 37

  Fly    76 EGDPRG-----SVRGRRLIT-------------------DLVYSRPPGMTSKKGVVGTHITVQAN 116
            .||||.     :.|.||.:.                   |.:.:||..:.||||..|..:.:|.|
  Fly    38 SGDPRADPRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTN 102

  Fly   117 YFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILG-GYIFDGTNMFCINQFKAVQDSPY 180
            :|::..:|.|.|..|.|:|.|.:|..|:|...|..|..:|| ||:|||..:|...:|:  |:
  Fly   103 FFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFE--QE--- 162

  Fly   181 VLELVTKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLE 245
            :..|..||:.....:|.||.||.:...:....|||||||||:|:||:|:||.|..:||:|||.:.
  Fly   163 ITVLSGKSKLDIEYKISIKFVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIR 227

  Fly   246 NFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDSDDYQSTFKRAVMGMVIL 310
            .|:|:|||||:|||||||.||||.:||.||||||||:|:|:.....:...:|...:..|:.:::|
  Fly   228 EFKMELWPGYETSIRQHEKDILLGTEITHKVMRTETIYDIMRRCSHNPARHQDEVRVNVLDLIVL 292

  Fly   311 TDYNNKTYRIDDVDFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN 375
            |||||:||||:||||..||...|.....:||:|:||..:|||.|||..|||::|:..||.::...
  Fly   293 TDYNNRTYRINDVDFGQTPKSTFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNA 357

  Fly   376 DQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSW 440
            .:.:::||||.|.||:...||::|:.:||||.:||:||.:|.:|||.||.||::..:||:.|:.|
  Fly   358 SELVVLIPELCRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDW 422

  Fly   441 NIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVH--INRWYVITPSRN 503
            |:|||..:.|:..|::..:.|:|.|.|: .....|||...||...|.....  ::||.||.|.||
  Fly   423 NMELDKNVTEVQGRIIGQQNIVFHNGKV-PAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRN 486

  Fly   504 LRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKY 568
            ..|.:..:....|.||.|.:.|.:|....|.|||.|||.:|:|:...:||::::.::.:.|.|:|
  Fly   487 SHELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERY 551

  Fly   569 SCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTV 633
            |.||||..|||.||:||||||.     .|...|||||||:.||:|.||...||.:.:||.||||:
  Fly   552 SSIKKRGYVDRAVPTQVVTLKT-----TKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTI 611

  Fly   634 GFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSL 698
            |||:..|.:::.::|||.:|:||.:::..|||||.|......|:..:...:|.|||.||.:||.|
  Fly   612 GFDIAKSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKL 676

  Fly   699 PERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRN 763
            |.||:|:||||..|.|.|:...||..:.::|...|... :....::.:|:|::.:|:|:|...:|
  Fly   677 PSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARV-QLSPPQLAYIVVTRSMNTRFFLNGQN 740

  Fly   764 PVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYS 828
            |.|||:|||||||||||||:||||.||.||||||||||:..:|||:.:|:|.|:|||.|:|||:|
  Fly   741 PPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWS 805

  Fly   829 GTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            ||.||||||.||.|||.||..:::..|...|:.:.|:|
  Fly   806 GTTRVPAVCQYAKKLATLVGTNLHSIPQNALEKKFYYL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	40/114 (35%)
		PAZ_piwi_like	272..392	CDD:239211	54/119 (45%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	210/450 (47%)
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	40/114 (35%)
		PAZ	262..396	CDD:198017	57/133 (43%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	210/450 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449119
Domainoid	1	1.000	146	1.000	Domainoid score	I4499
eggNOG	1	0.900	-	-		E1_KOG1042
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1044
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	1	1.000	-	-		otm14694
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	P	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
	11	10.800