DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and Piwil4

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001355760.1	Gene:	Piwil4 / 330890	MGIID:	3041167	Length:	848	Species:	Mus musculus

Alignment Length:	885	Identity:	294/885 - (33%)
Similarity:	457/885 - (51%)	Gaps:	69/885 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ARGRGRGRKPNNV--EANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQM 72
            ||.|.||....:.  |..|.....:...:.|..||        .|||.:.:....|        :
Mouse     5 ARVRARGITTGHSAREVGRSSRDLMVTSASPGDSE--------AGGGTSVISQPYE--------L 53

  Fly    73 HKSEGD-------PRGSVRGRRLITDLVYSRPPGMT----SKKGVVGTHITVQANYFKVLKRPNW 126
            ..|.||       .||  :||:...:|.......:|    .|.|..|..:.:..|.|.:....:|
Mouse    54 GVSSGDGGRTFMERRG--KGRQDFEELGVCTREKLTHVKDCKTGSSGIPVRLVTNLFNLDLPQDW 116

  Fly   127 TIYQYRVDFTPDVEATRLRRSFLYEHKGILG--GYIFDGTNMFCINQFKAVQDSPYVLELVTKSR 189
            .:|||.|.::||:.:.|||.:.||.| .||.  ...|||.::|...:.     ...|.||.::::
Mouse   117 QLYQYHVTYSPDLASRRLRIALLYNH-SILSDKAKAFDGASLFLSEKL-----DQKVTELTSETQ 175

  Fly   190 AGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPG 254
            .||.|:|.:.....:........|..|:|.|:.::.|.:..:.|.:|.|...:.:..:::.||||
Mouse   176 RGETIKITLTLTSKLFPNSPVCIQFFNVIFRKILKNLSMYQIGRNFYKPSEPVEIPQYKLSLWPG 240

  Fly   255 YQTSIRQHENDILLCSEICHKVMRTETLYNILSD-AIRDSDDYQSTF----KRAVMGMVILTDYN 314
            :..|:...|:.:|..:::.:||:|.||:.:.::| .:|..   .|.|    .:.::|:|:||.||
Mouse   241 FAISVSHFESKLLFNADVNYKVLRNETVLDFMTDLCLRTG---MSCFTEMCHKQLVGLVVLTRYN 302

  Fly   315 NKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQA 378
            ||||||||:|:...|...|:..|| |::||||||::|:|.:.||.||:::|....|.......|.
Mouse   303 NKTYRIDDIDWSVKPTQAFQKRDGSEVTYVDYYKQQYDITLSDLNQPVLVSLLKRKRNDNSEPQM 367

  Fly   379 IMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIE 443
            :.::|||...||::....:|||.::|::|.|||:|..|.::|......::....:...|::|.:.
Mouse   368 VHLMPELCFLTGLSSQATSDFRLMKAVAEETRLSPVGRQQQLARLVDDIQRNPVARFELETWGLH 432

  Fly   444 LDSALVEIPARVLPPEKILFGN---QKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLR 505
            ..|.| .:..||:|.||||..:   |..|.    |||:.:.|:|.:..:..:|||.::..:|...
Mouse   433 FGSQL-SLTGRVVPSEKILLQDHTCQPAFA----ADWSKDMRSCKVLSSQPLNRWLIVCCNRAEH 492

  Fly   506 ETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSC 570
            ..:.|:....|...||..|:..|...:: |:....:.:||......|.|:||.::.|..:..|..
Mouse   493 LIEAFLSCLRRVGGSMGFNVGYPKIIKV-DETPAAFLRAIQVHGDPDVQLVMCILPSNQKNYYDS 556

  Fly   571 IKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGF 635
            |||....|.|||||.|..:.:    .|...::|:|||:.:||..||.|..|.|.|||..||.||.
Mouse   557 IKKYLSSDCPVPSQCVLTRTL----NKQGTMLSVATKIAMQMTCKLGGELWSVEIPLKSLMVVGI 617

  Fly   636 DVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPE 700
            |:|....|||.....|||:::.:.: |:||.........::::.:.|.|..||..:...:..||.
Mouse   618 DICRDALNKNVVVVGFVASINSRIT-RWFSRCVLQRTAADIADCLKVCMTGALNRWYRHNHDLPA 681

  Fly   701 RILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF--TGH-- 761
            ||:.:|||||:|||..|:..||..|   |..:.:.......||::.::|.||...|.|  |.|
Mouse   682 RIVVYRDGVGNGQLKAVLEYEVPQL---LKSVTECGSDARSCRLSVVVVRKRCLLRLFASTDHTV 743

  Fly   762 RNPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYN 826
            :||..|||||...|.||.|||:|:||....||||||.||||.|:..|..|.:|.|::|:.|:|||
Mouse   744 QNPPLGTVVDSEATRPEWYDFYLISQTANRGTVSPTHYNVIYDDNALKPDHMQRLTFKLCHLYYN 808

  Fly   827 YSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            :.|.|.|||.|.|||||.||||:|:::.||..|.|.|::|
Mouse   809 WQGLISVPAPCQYAHKLTFLVAQSVHKEPSLELANNLFYL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	32/115 (28%)
		PAZ_piwi_like	272..392	CDD:239211	49/125 (39%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	166/455 (36%)
Piwil4	NP_001355760.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		13/54 (24%)
		PAZ	266..403	CDD:198017	54/139 (39%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	166/455 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837110
Domainoid	1	1.000	133	1.000	Domainoid score	I5041
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860