DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aub and Piwil2

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_006252333.2	Gene:	Piwil2 / 306011	RGDID:	1306964	Length:	1005	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	285/892 - (31%)
Similarity:	477/892 - (53%)	Gaps:	64/892 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLPPNPVIARGRGRGRKPNNVEANRGFAPSLGQ-KSDPSHSEGNQASGGNGGGGD---------A 56
            :||...|:|.|..:     ..||:.|::..||: .||.|.....:|:|..|.|.|         |
  Rat   151 SLPDPSVLAAGDSK-----LAEASVGWSRMLGRGSSDVSLLPLGRAAGSIGRGVDKPPSAFGLTA 210

  Fly    57 QVGPSI-EKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGMTSKKGVVGTHITVQANYFKV 120
            :..|.: :..:||...:|.|:..|        ::|  :..:...:..|:|..||..::..|..|:
  Rat   211 RDPPRLPQPPTLSPTSLHSSDPPP--------VLT--IERKEKELLVKQGSKGTPQSLGLNLIKI 265

  Fly   121 LKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGGY-IFDGTNMFCINQFKAVQDSPYVLEL 184
             :..|..:|||.|.|:|:||...:|...|.:|:.:.|.. .|||:.::.  ..|..|    ::||
  Rat   266 -QCHNEAVYQYHVTFSPNVECKSMRFGMLKDHQSVTGNVTAFDGSILYL--PVKLQQ----LVEL 323

  Fly   185 VTKSRAGE-NIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFR 248
            .::.:..: .|.|||:....::..........|::.||.|:.||:|||.|.:|||.:.:.|:..|
  Rat   324 KSQRKTDDAEISIKIQLTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHR 388

  Fly   249 MQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAI--RDSDDYQSTFKRAVMGMVILT 311
            :|:||||..|||:.:..:.|.:::.|||:|.:::.::: .||  ::.:.:|....:.::|.:::|
  Rat   389 LQIWPGYAASIRRTDGGLFLLADVSHKVIRNDSVLDVM-HAIYQQNKEHFQDECSKLLVGSIVIT 452

  Fly   312 DYNNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN 375
            .|||:||||||||:..||...|..:|| ||::::||.|.|.|.:::..|||::.||:::....|.
  Rat   453 RYNNRTYRIDDVDWNKTPKDSFVMSDGKEITFLEYYSKNYGITVKEDDQPLLIHRPSERQNNHGT 517

  Fly   376 --DQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLK 438
              ...|:::|||:..||:.:.|:.|||.::.:::...|:|.:....|....:|:...:.:...|.
  Rat   518 LLKGEILLLPELSFMTGIPEKMKKDFRAMKDLTQQINLSPKQHHSALECLLQRISQNETANNELT 582

  Fly   439 SWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRN 503
            .|.:.|...:.:|..|:||.|:|...|.. ||.....:|..|....:....:.::.|.:..|.|.
  Rat   583 RWGLSLQKDVHKIEGRLLPMERINLRNTS-FVTSEDLNWVKEVTRDASILTIPMHFWALFYPKRA 646

  Fly   504 LRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVV--MRSPNEE 566
            :.:.:|.|.|..:.|..:.|.|..|.:.|:.|||..||.:.|.:....:.:|.|||  :....::
  Rat   647 MDQARELVNMLEKIAGPIGMRISPPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDD 711

  Fly   567 KYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLM 631
            .|..|||..||..||||||:.::.|.    :||.|.|:|.|:::|||.||.|..|.|.|||..||
  Rat   712 LYGAIKKLCCVQSPVPSQVINVRTIG----QPTRLRSVAQKILLQMNCKLGGELWGVDIPLKQLM 772

  Fly   632 TVGFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHR 696
            .:|.||.|.|....:|...|||:::...: :::|.|...:..||:.:.:.:.:..:|:.|.|.:.
  Rat   773 VIGMDVYHDPSRGMRSVVGFVASINLTLT-KWYSRVVFQMPHQEIVDSLKLCLVGSLKKYYEVNH 836

  Fly   697 SLPERILFFRDGVGDGQLYQVVNSEVNTLK---DRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF 758
            .|||:|:.:||||.||||..|.|.|:..|:   :..|..:.        :|...:|.|:|::..:
  Rat   837 CLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAFDNYHP--------KMVVFVVQKKISTNLY 893

  Fly   759 TGHRN----PVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYK 819
            ....:    |.||||||..||..|..||:|::..||.|...||.|..:.:...|:.|.:|.|::|
  Rat   894 LAAPDHFVTPSPGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFK 958

  Fly   820 MTHMYYNYSGTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            :.|||:|:.|||||||.|.||||||||..:.::..|:..|...|:||
  Rat   959 LCHMYWNWPGTIRVPAPCKYAHKLAFLSGQILHHEPAIQLCENLFFL 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	30/115 (26%)
		PAZ_piwi_like	272..392	CDD:239211	44/124 (35%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	153/457 (33%)
Piwil2	XP_006252333.2	ArgoN	250..>346	CDD:293095	29/102 (28%)
		ArgoL1	371..418	CDD:285861	19/46 (41%)
		PAZ_piwi_like	419..536	CDD:239211	40/117 (34%)
		Piwi_piwi-like_Euk	544..988	CDD:240016	153/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340833
Domainoid	1	1.000	113	1.000	Domainoid score	I5968
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.620