DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and Ago4

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_006238924.1	Gene:	Ago4 / 298533	RGDID:	1304583	Length:	861	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	210/919 - (22%)
Similarity:	360/919 - (39%)	Gaps:	224/919 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSF---LYEH--KGI 155
            |.||:    |.||..|.:.||:|:| :.|...:|.|.||..|:....|:.|..   :..|  ..|
  Rat    17 RRPGL----GTVGKPIRLLANHFQV-QIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQI 76

  Fly   156 LG----GYIFDG-TNMFCINQFKAVQD------------------------SPYVLELVTKSRAG 191
            .|    ||  || .||:..:.....:|                        |...|:|:.::.||
  Rat    77 FGDRQPGY--DGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAG 139

  Fly   192 ENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENF------RMQ 250
            ...|:   ...|||:.|         ::.|.:..:....|.|.::.|.     |.:      ..:
  Rat   140 HLSEV---PDDSVQALD---------VITRHLPSMRYTPVGRSFFSPP-----EGYYHPLGGGRE 187

  Fly   251 LWPGYQTSIRQHENDILL-----------CSEICHKVMRTETLYNILSDAIRDSDDYQSTFKRAV 304
            :|.|:..|:|.....::|           ...|...:.....:.||.......:|..:..|.:.:
  Rat   188 VWFGFHQSVRPAMWKMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEI 252

  Fly   305 MGMVILTDY---NNKTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPL 361
            .|:.:...:   ..:.||:.:|     ..|:.||........|.:...|:|::||:.::....|.
  Rat   253 RGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYNLQLKYSHLPC 317

  Fly   362 VMSRPTDKNIRGGNDQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRRIERLRMF 423
                     ::.|.:|....:| |:.........::  .|.:|...:....|..|||:.|..|:
  Rat   318 ---------LQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRL- 372

  Fly   424 NKRLKSCKQSV-----ETLKSWNIELDSALVEIPARVLPPEKILFGNQ-KIFVCDARADWTNEFR 482
               :||  .||     ..||.:.|.:.:.:.|:..||||...:.:|.: |......:..|  :.|
  Rat   373 ---VKS--NSVLGGPDPYLKEFGIVVHNEMTELMGRVLPAPMLQYGGRNKTVATPNQGVW--DMR 430

  Fly   483 TCSMFKNVHINRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI------CNPIYEEIPDDR 537
            ....:..:.|..|.|  ..|.:..||  .:.|.....:.:....|.|      |.
  Rat   431 GKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCK---------- 485

  Fly   538 NGTYSQAIDNAAANDP------------QIVMVVM--RSPNEEKYSCIKKRTCVDRPVPSQVVTL 588
               |:|..|:.   :|            |:::|::  ::|   .|:.:|:.......:.:|.|.:
  Rat   486 ---YAQGADSV---EPMFKHLKMTYVGLQLIVVILPGKTP---VYAEVKRVGDTLLGMATQCVQV 541

  Fly   589 KVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHSP--KNK 644
            |.:.  :..|..|.::..|:    ||||.|.. .|::|       ...::.:|.||.|.|  ..|
  Rat   542 KNVV--KTSPQTLSNLCLKI----NAKLGGIN-NVLVPHQRPSVFQQPVIFLGADVTHPPAGDGK 599

  Fly   645 NKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACA----------LRSYQEQHRSLP 699
            ..|..|.|.:||...| ||.:||......||:::::..:....          |..:.:..|..|
  Rat   600 KPSIAAVVGSMDGHPS-RYCATVRVQTSRQEIAQELLFSQEVVQDLTSMARELLIQFYKSTRFKP 663

  Fly   700 ERILFFRDGVGDGQLYQVVNSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYF--- 758
            .||:::|.||.:||:.||...|:..::.   .|:|.|:..       :|:|:|.||.::|.|
  Rat   664 TRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPG-------ITYIVVQKRHHTRLFCAD 721

  Fly   759 ----TGHRNPVP-GTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSY 818
                .|....|| ||.||..||.|..:||:|.|.|...||..|:.|.|:.|:....||:||:|:|
  Rat   722 KTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTY 786

  Fly   819 KMTHMYYNYSGTIRVPAVCHYAHKLAF------------------LVAESINRAPSA-------- 857
            ::.|.|...:.::.:||..:||..:||                  :..:|..|.|.|
  Rat   787 QLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIH 851

  Fly   858 -GLQNQLYF 865
             ..|:.:||
  Rat   852 HDTQHTMYF 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	36/147 (24%)
		PAZ_piwi_like	272..392	CDD:239211	22/128 (17%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	131/526 (25%)
Ago4	XP_006238924.1	PLN03202	15..860	CDD:215631	208/917 (23%)
		ArgoN	18..155	CDD:293095	38/155 (25%)
		ArgoL1	167..216	CDD:285861	9/53 (17%)
		PAZ_argonaute_like	217..337	CDD:239212	22/128 (17%)
		Piwi_ago-like	384..819	CDD:240015	120/470 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910