Protein Alignment aub and AGO2

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_011515267.1
• Gene: AGO2 / 27161
• HGNCID: 3263
• Length: 873
• Species: Homo sapiens
• Alignment Length: 846
• Identity: 199/846 - (23%)
• Similarity: 364/846 - (43%)
• Gaps: 149/846 - (17%)

  Fly    94 YSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEH------ 152
            |:..|......|..|..|.:|||:|: :..|...||.|.:|..|:....|:.|. :.||
Human    35 YAFKPPPRPDFGTSGRTIKLQANFFE-MDIPKIDIYHYELDIKPEKCPRRVNRE-IVEHMVQHFK 97

  Fly   153 KGILGGY--IFDG-TNMFCINQFKAVQDSPYVLEL-VTKSRAGEN--IEIKIKAV---------- 201
            ..|.|..  :||| .|::........:|.   :|| ||....|::  .::.||.|
Human    98 TQIFGDRKPVFDGRKNLYTAMPLPIGRDK---VELEVTLPGEGKDRIFKVSIKWVSCVSLQALHD 159

  Fly   202 ---GSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYD-PQAKINLENFRMQLWPGYQTSIRQH 262
               |.:.|...|..|.|::::|. :..:....|.|.::. .:...|......::|.|:..|:|..
Human   160 ALSGRLPSVPFETIQALDVVMRH-LPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPS 223

  Fly   263 ENDILLCSEIC----HKVMRT-ETLYNILS-DAIRD-----SDDYQSTFKRAVMGMVILTDY--- 313
            ...::|..::.    :|.... |.:..:|. .:|.:     :|..:..|.:.:.|:.:...:
Human   224 LWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQ 288

  Fly   314 NNKTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRG 373
            ..:.||:.:|     ..|:.||.:......|.:...|:|.|:.:::|....|.         ::.
Human   289 MKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPC---------LQV 344

  Fly   374 GNDQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVE 435
            |.:|....:| |:.........::  .|.:|...:....|..|||:.|    .:|.::|...:.:
Human   345 GQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEE----ISKLMRSASFNTD 405

  Fly   436 T-LKSWNIELDSALVEIPARVLPPEKILFGNQ-KIFVCDARADWTNEFRTCSMFKNVHINRWYV- 497
            . ::.:.|.:...:.::..|||.|..||:|.: |......:..|  :.|.......:.|..|.:
Human   406 PYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVW--DMRNKQFHTGIEIKVWAIA 468

  Fly   498 -ITPSRNLRET--QEFVQMCIRTASSMKMNI------CNPIYEEIPDDRNGTYSQAIDNAAANDP 553
             ..|.|...|.  :.|.:...:.:....|.|      |.             |:|..|:.   :|
Human   469 CFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCK-------------YAQGADSV---EP 517

  Fly   554 ------------QIVMVVM--RSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSI 604
                        |:|:|::  ::|   .|:.:|:.......:.:|.|.:|.:  ::..|..|.::
Human   518 MFRHLKNTYAGLQLVVVILPGKTP---VYAEVKRVGDTVLGMATQCVQMKNV--QRTTPQTLSNL 577

  Fly   605 ATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHSP--KNKNKSYGAFVATMDQKES 660
            ..|:    |.||.|.. .:::|       ...::.:|.||.|.|  ..|..|..|.|.:||...:
Human   578 CLKI----NVKLGGVN-NILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPN 637

  Fly   661 FRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTL 725
             ||.:||......||:.:.::..:...|..:.:..|..|.||:|:||||.:||..||::.|:..:
Human   638 -RYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAI 701

  Fly   726 KD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRNP-------VP-GTVVDDVITLPER 779
            ::   :|::.|     |.|  :|||:|.||.::|.|...:|.       :| ||.||..||.|..
Human   702 REACIKLEKDY-----QPG--ITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTE 759

  Fly   780 YDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLA 844
            :||:|.|.|...||..|:.|:|:.|:...::|:||:|:|::.|.|...:.::.:||..:|||.:|
Human   760 FDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVA 824

  Fly   845 F 845
            |
Human   825 F 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	23/139 (17%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	127/492 (26%)
AGO2	XP_011515267.1	ArgoN	106..180	CDD:465134	18/76 (24%)
		ArgoL1	190..240	CDD:462567	8/49 (16%)
		PAZ_argonaute_like	241..361	CDD:239212	22/128 (17%)
		Piwi_ago-like	406..831	CDD:240015	119/456 (26%)