DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and AGO1

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001304051.1	Gene:	AGO1 / 26523	HGNCID:	3262	Length:	891	Species:	Homo sapiens

Alignment Length:	868	Identity:	205/868 - (23%)
Similarity:	369/868 - (42%)	Gaps:	158/868 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EGDPRGSVRGRRL-ITDLVYSRP--PGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTP 137
            |..|.|:..|..| ....|:..|  ||:    |.||..|.:.||||:| ..|...:|.|.||..|
Human     2 EAGPSGAAAGAYLPPLQQVFQAPRRPGI----GTVGKPIKLLANYFEV-DIPKIDVYHYEVDIKP 61

  Fly   138 DVEATRLRR---SFLYEH--KGILGGY--IFDG-TNMFCINQFKAVQDSPYVLELVTKSRAGENI 194
            |....|:.|   .::.:|  ..|.|..  ::|| .|::.:... .:.:.....|:.......:.|
Human    62 DKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTAL-PIGNERVDFEVTIPGEGKDRI 125

  Fly   195 -EIKIKAVGSVQ-------------STDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLE 245
             ::.||.:..|.             ....|..|.|::.:|. :..:....|.|.::.|.     |
Human   126 FKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRH-LASMRYTPVGRSFFSPP-----E 184

  Fly   246 NF------RMQLWPGYQTSIRQHENDILLCSEIC----HKVMRT-ETLYNILSDAIRD------- 292
            .:      ..::|.|:..|:|.....::|..::.    :|.... |.:..:|.  ||:
Human   185 GYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLD--IRNIDEQPKP 247

  Fly   293 -SDDYQSTFKRAVMGMVILTDY---NNKTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKK 348
             :|..:..|.:.:.|:.:...:   ..:.||:.:|     ..|:.||........|.:...|:|:
Human   248 LTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQ 312

  Fly   349 RYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTR 410
            :||:   .||.|.:..      ::.|.:|....:| |:.........::  .|.:|...:....|
Human   313 KYNL---QLKYPHLPC------LQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR 368

  Fly   411 LNPDRRIERLRMFNKRLKSCKQSVET-LKSWNIELDSALVEIPARVLPPEKILFGNQ-KIFVCDA 473
            ..|||:.|..|:    :|:...:::. ::.:.|::...:.|:..||||...:.:|.: :......
Human   369 SAPDRQEEISRL----MKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPN 429

  Fly   474 RADWTNEFRTCSMFKNVHINRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI------C-- 526
            :..|  :.|....:..:.|..|.:  ..|.:..||  .:.|.....:.:....|.|      |
Human   430 QGVW--DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKY 492

  Fly   527 -------NPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVM--RSPNEEKYSCIKKRTCVDRPVP 582
                   .|::..:    ..|||..         |:::|::  ::|   .|:.:|:.......:.
Human   493 AQGADSVEPMFRHL----KNTYSGL---------QLIIVILPGKTP---VYAEVKRVGDTLLGMA 541

  Fly   583 SQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHS 640
            :|.|.:|.:.  :..|..|.::..|:    |.||.|.. .:::|       ...::.:|.||.|.
Human   542 TQCVQVKNVV--KTSPQTLSNLCLKI----NVKLGGIN-NILVPHQRSAVFQQPVIFLGADVTHP 599

  Fly   641 P--KNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERIL 703
            |  ..|..|..|.|.:||...| ||.:||......||:.|.:|..:...|..:.:..|..|.||:
Human   600 PAGDGKKPSITAVVGSMDAHPS-RYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRII 663

  Fly   704 FFRDGVGDGQLYQVVNSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRNP- 764
            |:||||.:|||.|:::.|:..::|   :|::.|     |.|  :|:|:|.||.::|.|...:|.
Human   664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDY-----QPG--ITYIVVQKRHHTRLFCADKNER 721

  Fly   765 ------VP-GTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTH 822
                  :| ||.||..||.|..:||:|.|.|...||..|:.|.|:.|:....||:||:|:|::.|
Human   722 IGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCH 786

  Fly   823 MYYNYSGTIRVPAVCHYAHKLAF 845
            .|...:.::.:||..:||..:||
Human   787 TYVRCTRSVSIPAPAYYARLVAF 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	32/135 (24%)
		PAZ_piwi_like	272..392	CDD:239211	26/141 (18%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	127/489 (26%)
AGO1	NP_001304051.1	PLN03202	26..856	CDD:215631	198/844 (23%)
		ArgoN	26..164	CDD:293095	34/143 (24%)
		ArgoL1	175..224	CDD:285861	9/53 (17%)
		PAZ_argonaute_like	225..345	CDD:239212	25/130 (19%)
		Piwi_ago-like	390..815	CDD:240015	119/453 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910