Protein Alignment aub and AGO1

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001304051.1
• Gene: AGO1 / 26523
• HGNCID: 3262
• Length: 891
• Species: Homo sapiens
• Alignment Length: 868
• Identity: 205/868 - (23%)
• Similarity: 369/868 - (42%)
• Gaps: 158/868 - (18%)

  Fly    76 EGDPRGSVRGRRL-ITDLVYSRP--PGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTP 137
            |..|.|:..|..| ....|:..|  ||:    |.||..|.:.||||:| ..|...:|.|.||..|
Human     2 EAGPSGAAAGAYLPPLQQVFQAPRRPGI----GTVGKPIKLLANYFEV-DIPKIDVYHYEVDIKP 61

  Fly   138 DVEATRLRR---SFLYEH--KGILGGY--IFDG-TNMFCINQFKAVQDSPYVLELVTKSRAGENI 194
            |....|:.|   .::.:|  ..|.|..  ::|| .|::.:... .:.:.....|:.......:.|
Human    62 DKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTAL-PIGNERVDFEVTIPGEGKDRI 125

  Fly   195 -EIKIKAVGSVQ-------------STDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLE 245
             ::.||.:..|.             ....|..|.|::.:|. :..:....|.|.::.|.     |
Human   126 FKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRH-LASMRYTPVGRSFFSPP-----E 184

  Fly   246 NF------RMQLWPGYQTSIRQHENDILLCSEIC----HKVMRT-ETLYNILSDAIRD------- 292
            .:      ..::|.|:..|:|.....::|..::.    :|.... |.:..:|.  ||:
Human   185 GYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLD--IRNIDEQPKP 247

  Fly   293 -SDDYQSTFKRAVMGMVILTDY---NNKTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKK 348
             :|..:..|.:.:.|:.:...:   ..:.||:.:|     ..|:.||........|.:...|:|:
Human   248 LTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQ 312

  Fly   349 RYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTR 410
            :||:   .||.|.:..      ::.|.:|....:| |:.........::  .|.:|...:....|
Human   313 KYNL---QLKYPHLPC------LQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR 368

  Fly   411 LNPDRRIERLRMFNKRLKSCKQSVET-LKSWNIELDSALVEIPARVLPPEKILFGNQ-KIFVCDA 473
            ..|||:.|..|:    :|:...:::. ::.:.|::...:.|:..||||...:.:|.: :......
Human   369 SAPDRQEEISRL----MKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPN 429

  Fly   474 RADWTNEFRTCSMFKNVHINRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI------C-- 526
            :..|  :.|....:..:.|..|.:  ..|.:..||  .:.|.....:.:....|.|      |
Human   430 QGVW--DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKY 492

  Fly   527 -------NPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVM--RSPNEEKYSCIKKRTCVDRPVP 582
                   .|::..:    ..|||..         |:::|::  ::|   .|:.:|:.......:.
Human   493 AQGADSVEPMFRHL----KNTYSGL---------QLIIVILPGKTP---VYAEVKRVGDTLLGMA 541

  Fly   583 SQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHS 640
            :|.|.:|.:.  :..|..|.::..|:    |.||.|.. .:::|       ...::.:|.||.|.
Human   542 TQCVQVKNVV--KTSPQTLSNLCLKI----NVKLGGIN-NILVPHQRSAVFQQPVIFLGADVTHP 599

  Fly   641 P--KNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERIL 703
            |  ..|..|..|.|.:||...| ||.:||......||:.|.:|..:...|..:.:..|..|.||:
Human   600 PAGDGKKPSITAVVGSMDAHPS-RYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRII 663

  Fly   704 FFRDGVGDGQLYQVVNSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGHRNP- 764
            |:||||.:|||.|:::.|:..::|   :|::.|     |.|  :|:|:|.||.::|.|...:|.
Human   664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDY-----QPG--ITYIVVQKRHHTRLFCADKNER 721

  Fly   765 ------VP-GTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTH 822
                  :| ||.||..||.|..:||:|.|.|...||..|:.|.|:.|:....||:||:|:|::.|
Human   722 IGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCH 786

  Fly   823 MYYNYSGTIRVPAVCHYAHKLAF 845
            .|...:.::.:||..:||..:||
Human   787 TYVRCTRSVSIPAPAYYARLVAF 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	26/141 (18%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	127/489 (26%)
AGO1	NP_001304051.1	ArgoN	34..164	CDD:465134	29/131 (22%)
		ArgoL1	174..224	CDD:462567	9/54 (17%)
		PAZ_argonaute_like	225..345	CDD:239212	25/130 (19%)
		Piwi_ago-like	390..815	CDD:240015	119/453 (26%)