DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and AGO4

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_060099.2	Gene:	AGO4 / 192670	HGNCID:	18424	Length:	861	Species:	Homo sapiens

Alignment Length:	916	Identity:	212/916 - (23%)
Similarity:	360/916 - (39%)	Gaps:	218/916 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSF---LYEH--KGI 155
            |.||:    |.||..|.:.||:|:| :.|...:|.|.||..|:....|:.|..   :..|  ..|
Human    17 RRPGL----GTVGKPIRLLANHFQV-QIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQI 76

  Fly   156 LG----GYIFDG-TNMFCINQFKAVQD------------------------SPYVLELVTKSRAG 191
            .|    ||  || .||:..:.....:|                        |...|:|:.::.||
Human    77 FGDRQPGY--DGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAG 139

  Fly   192 ENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENF------RMQ 250
            ...|:   ...|||:.|         ::.|.:..:....|.|.::.|.     |.:      ..:
Human   140 HLNEV---PDDSVQALD---------VITRHLPSMRYTPVGRSFFSPP-----EGYYHPLGGGRE 187

  Fly   251 LWPGYQTSIRQHENDILL-----------CSEICHKVMRTETLYNILSDAIRDSDDYQSTFKRAV 304
            :|.|:..|:|....:::|           ...|...:.....:.||.......:|..:..|.:.:
Human   188 VWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEI 252

  Fly   305 MGMVILTDY---NNKTYRIDDV-----DFQSTPLCKFKTNDGEISYVDYYKKRYNIIIRDLKQPL 361
            .|:.:...:   ..:.||:.:|     ..|:.||........|.:...|:|::|::   .||.|.
Human   253 RGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSL---QLKYPH 314

  Fly   362 VMSRPTDKNIRGGNDQAIMIIP-ELARATGMTDAMR--ADFRTLRAMSEHTRLNPDRR--IERLR 421
            :..      ::.|.:|....:| |:.........::  .|.:|...:....|..|||:  |.||.
Human   315 LPC------LQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLV 373

  Fly   422 MFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQ-KIFVCDARADWTNEFRTCS 485
            ..|..:..   ....||.:.|.:.:.:.|:..||||...:.:|.: |......:..|  :.|...
Human   374 KSNSMVGG---PDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVW--DMRGKQ 433

  Fly   486 MFKNVHINRWYV--ITPSRNLRE--TQEFVQMCIRTASSMKMNI------CNPIYEEIPDDRNGT 540
            .:..:.|..|.|  ..|.:..||  .:.|.....:.:....|.|      |.
Human   434 FYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCK------------- 485

  Fly   541 YSQAIDNAAANDP------------QIVMVVM--RSPNEEKYSCIKKRTCVDRPVPSQVVTLKVI 591
            |:|..|:.   :|            |:::|::  ::|   .|:.:|:.......:.:|.|.:|.:
Human   486 YAQGADSV---EPMFKHLKMTYVGLQLIVVILPGKTP---VYAEVKRVGDTLLGMATQCVQVKNV 544

  Fly   592 APRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP-------LHGLMTVGFDVCHSP--KNKNKS 647
            .  :..|..|.::..|:    ||||.|.. .|::|       ...::.:|.||.|.|  ..|..|
Human   545 V--KTSPQTLSNLCLKI----NAKLGGIN-NVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPS 602

  Fly   648 YGAFVATMDQKESFRYFSTVNEHIKGQELSEQM---------SVNMACALR-SYQEQHRSLPERI 702
            ..|.|.:||...| ||.:||......||:|:::         ..||...|. .:.:..|..|.||
Human   603 IAAVVGSMDGHPS-RYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRI 666

  Fly   703 LFFRDGVGDGQLYQVVNSEVNTLKD---RLDEIYKSAGKQEGCRMTFIIVSKRINSRYF------ 758
            :::|.||.:||:.||...|:..::.   .|:|.|:..       :|:|:|.||.::|.|
Human   667 IYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPG-------ITYIVVQKRHHTRLFCADKTE 724

  Fly   759 -TGHRNPVP-GTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMT 821
             .|....|| ||.||..||.|..:||:|.|.|...||..|:.|.|:.|:....||:||:|:|::.
Human   725 RVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLC 789

  Fly   822 HMYYNYSGTIRVPAVCHYAHKLAF------------------LVAESINRAPSA---------GL 859
            |.|...:.::.:||..:||..:||                  :..:|..|.|.|         ..
Human   790 HTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDT 854

  Fly   860 QNQLYF 865
            |:.:||
Human   855 QHTMYF 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	36/147 (24%)
		PAZ_piwi_like	272..392	CDD:239211	23/128 (18%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	132/523 (25%)
AGO4	NP_060099.2	ArgoN	26..155	CDD:406799	33/143 (23%)
		ArgoL1	166..216	CDD:400854	9/54 (17%)
		PAZ_argonaute_like	217..337	CDD:239212	23/128 (18%)
		Piwi_ago-like	384..819	CDD:240015	123/470 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	825..846		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910