DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and alg-1

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001367206.1	Gene:	alg-1 / 181504	WormBaseID:	WBGene00000105	Length:	1023	Species:	Caenorhabditis elegans

Alignment Length:	945	Identity:	219/945 - (23%)
Similarity:	371/945 - (39%)	Gaps:	213/945 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 APS--LGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKSEGDPRGSVRGRRLITD 91
            ||.  :|..|.......|...||..||...|    :...:.|.:|..    .||
Worm   116 APGVPIGNTSVSIGEPANTLGGGLPGGAPGQ----LPGGNQSGIQFQ----CPR----------- 161

  Fly    92 LVYSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGIL 156
                ||     ..||.|..|.::||:|.| :.|..||..|:||.|||....|:.|..:.......
Worm   162 ----RP-----NHGVEGRSILLRANHFAV-RIPGGTIQHYQVDVTPDKCPRRVNREIISCLISAF 216

  Fly   157 GGY------IFDG-TNMFCINQFKAVQD-SPYVLELVTKSRAGENIEIKIKAVGSVQ-ST--DA- 209
            ..|      ::|| .||:........:: ..:.:.|...|.......:.:|.||.|. ||  ||
Worm   217 SKYFTNIRPVYDGKRNMYTREPLPIGRERMDFDVTLPGDSAVERQFSVSLKWVGQVSLSTLEDAM 281

  Fly   210 ---------EQFQVLNLILRRAMEGLDLKLVSRYYYDP--------------------------- 238
                     |..|.:::|||. :..|....|.|.::.|
Worm   282 EGRVRQVPFEAVQAMDVILRH-LPSLKYTPVGRSFFSPPVPNASGVMAGSCPPQASGAVAGGAHS 345

  Fly   239 ----QAKINLENFRMQLWPGYQTSIRQHENDILLCSEICHKVM-RTETLYNILSDAIR------- 291
                .|:..|...| ::|.|:..|:|..:..::|..::..... |:..:...:::.:.
Worm   346 AGQYHAESKLGGGR-EVWFGFHQSVRPSQWKMMLNIDVSATAFYRSMPVIEFIAEVLELPVQALA 409

  Fly   292 ----DSDDYQSTFKRAVMGMVILTDY---NNKTYRIDDV-----DFQSTPLCKFKTNDG-EISYV 343
                .||..:..|.:.:.|:.|...:   ..:.||:.:|     ..|:.|| :.:|... |.:..
Worm   410 ERRALSDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQTQTFPL-QLETGQTIECTVA 473

  Fly   344 DYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIPELARATGMTDAMR-----ADFRTLR 403
            .|:..:|.|   .||.|.:..      ::.|.:|....:|  .....:....|     .|.:|..
Worm   474 KYFYDKYRI---QLKYPHLPC------LQVGQEQKHTYLP--PEVCNIVPGQRCIKKLTDVQTST 527

  Fly   404 AMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETL-KSWNIELDSALVEIPARVLPPEKILFG--- 464
            .:....|..|    ||.|..:..::..:.|.:.. ..:.|.::.|:.|:..|||...|:|:|
Worm   528 MIKATARSAP----EREREISNLVRKAEFSADPFAHEFGITINPAMTEVKGRVLSAPKLLYGGRT 588

  Fly   465 ------NQKIFVCDARADWTNEFRTCSMFKNVHINRWYV--ITPSRNLRET--QEFVQMCIRTAS 519
                  ||.::  |.|.   .:|.|     .:.:..|.:  ....::::|.  :.|.....|.::
Worm   589 RATALPNQGVW--DMRG---KQFHT-----GIDVRVWAIACFAQQQHVKENDLRMFTNQLQRISN 643

  Fly   520 SMKM----NIC-----------NPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVM--RSPNEEK 567
            ...|    |.|           .|:::.:..:.:|.             |:|:||:  ::|   .
Worm   644 DAGMPIVGNPCFCKYAVGVEQVEPMFKYLKQNYSGI-------------QLVVVVLPGKTP---V 692

  Fly   568 YSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIP------ 626
            |:.:|:.......:.:|.|..|...  :..|..|.::..|    ||.||.|.. .:::|
Worm   693 YAEVKRVGDTVLGIATQCVQAKNAI--RTTPQTLSNLCLK----MNVKLGGVN-SILLPNVRPRI 750

  Fly   627 -LHGLMTVGFDVCHSP--KNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACAL 688
             ...::..|.|:.|.|  .::..|..|.|.:||...| ||.:||......||:...::..:...|
Worm   751 FNEPVIFFGCDITHPPAGDSRKPSIAAVVGSMDAHPS-RYAATVRVQQHRQEIISDLTYMVRELL 814

  Fly   689 RSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRI 753
            ..:....|..|.||:.:||||.:||.:.|:..|:..:::..  :....|.|.|  :|||.|.||.
Worm   815 VQFYRNTRFKPARIVVYRDGVSEGQFFNVLQYELRAIREAC--MMLERGYQPG--ITFIAVQKRH 875

  Fly   754 NSRYFTGHR--------NPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNA 810
            ::|.|...:        |..|||.||..||.|..:||:|.|.|...||..|:.|:|:.|:..|.|
Worm   876 HTRLFAVDKKDQVGKAYNIPPGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTA 940

  Fly   811 DKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAF 845
            |:||.|:|:|.|.|...:.::.:||..:|||.:||
Worm   941 DELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAF 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	36/134 (27%)
		PAZ_piwi_like	272..392	CDD:239211	23/140 (16%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	127/494 (26%)
alg-1	NP_001367206.1	ArgoN	170..300	CDD:406799	33/130 (25%)
		ArgoL1	310..389	CDD:400854	11/79 (14%)
		PAZ_argonaute_like	390..511	CDD:239212	22/132 (17%)
		Piwi_ago-like	556..981	CDD:240015	120/458 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910