Protein Alignment aub and ergo-1

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_503362.2
• Gene: ergo-1 / 178602
• WormBaseID: WBGene00019971
• Length: 1121
• Species: Caenorhabditis elegans
• Alignment Length: 1076
• Identity: 221/1076 - (20%)
• Similarity: 388/1076 - (36%)
• Gaps: 306/1076 - (28%)

  Fly    14 GRGRKPNNVEANRGFAPSLGQKSDPSHSEGNQAS--GGNGGGGDAQVGPSIEKSSLSAVQMHKSE 76
            |..::.:|...|||           ||...|..|  |||.|||..:||.....:.:|      :.
 Worm    99 GSNQRNDNYGNNRG-----------SHGGANMYSQNGGNRGGGGGRVGGGRTAAGMS------NP 146

  Fly    77 GDPRG---------SVRGRRLITDLVYSRPPGMTSKKGVVGTHITVQANYFKV-LKRPNWTIYQY 131
            ||..|         |.:..|........||..|...|| :|...|:..|:..| |.:...|::.:
 Worm   147 GDLVGGADQPIHSVSKKSLRHNAQEFAVRPKTMVQDKG-LGQKTTLLTNHTLVQLPQEPITLHVF 210

  Fly   132 RVDFTPDVEATRLRR-------SFLYEHK---GILGGYIFDGTN-MFCINQFKAVQDSP------ 179
            .::...:.:::..|.       ..|.|:|   |:...|||:..| |:..|:.:..:...
 Worm   211 NIEVFINGKSSNKRELCGPRFWEILKENKPTFGMPNQYIFNDVNMMWSTNKLRQSEGRTNNRRMN 275

  Fly   180 YVLELVTKSRAGENIEIKIKAVGSVQSTDAEQFQVLN-LILRRAMEGLDLKLVSRYY-------- 235
            :|.:.|.:.:.|.|||            |.|..|:|: ||...|.:...|.|....|
 Worm   276 FVWKYVKQIKFGGNIE------------DEETMQLLSTLIDAIATQRARLPLAPPKYTVFKRLTY 328

  Fly   236 ------YDPQ---------------AKINLE-----NFRMQLW------------PGYQTSIRQH 262
                  |:|:               |::.:.     |.|..:.            |.|.. :|
 Worm   329 LICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRAGITACFDLGHTLFTRPAYPL-VR-- 390

  Fly   263 ENDILLCSEICHKVMRTETL---YNILSDAIRDSDDYQSTFKRAVMGMVILTDYNNKTYRIDD-- 322
                |||..|.|.|:..|..   |:....|...||:......:.:..|.:........|..:|
 Worm   391 ----LLCDIIEHSVVLDEAFEMKYDAALRACNVSDENLRVMTQILTKMTLQLSTETGDYVGEDGE 451

  Fly   323 VDFQSTPLCK-----FK-------------TNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTD 368
            |..:..|..:     ||             |:|| |::..|||.::|||.:|....|.|:.:..:
 Worm   452 VIVRPAPTIRNPGRNFKFVGLGAPADRYYFTSDGVELTVADYYLQKYNIRLRYPNLPCVLKKAPE 516

  Fly   369 KNIRGGNDQAIM--------IIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLR--MF 423
               :.||..:.|        ::|.......|.| ||||      |...|.....:|.:.|:  :.
 Worm   517 ---QCGNKHSAMPLELVSYIVVPTRYGGFTMPD-MRAD------MINKTTYTAQQRGKLLQHIIA 571

  Fly   424 NKRLKSCKQSV----ETLKSWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTC 484
            .|.|...:..|    :.:|...:.:....:.:.|.:|||..:::|:
 Worm   572 QKSLSGIEPPVSNNDDYMKKHKLVMKREPIRVKATILPPPTLVYGD------------------- 617

  Fly   485 SMFKNV-HINRWYVIT--PSRNLRETQEFVQMCIRTASS--MKMNICNPIYEEIPDD-RNGTYSQ 543
            |:|.:. ||..|..:|  |.|.:.:...|.:...:::..  ||..:.:.:..:.|.. |:..|:|
 Worm   618 SVFHDEHHIGEWEAVTHDPPRQVLDGAVFRRKLYKSSEQPLMKRLMGSILLIQSPRQCRDFDYNQ 682

  Fly   544 ----AIDNAAANDPQIVMVVMRSPNEEKYSCI-----------------------KKRTCVDRPV 581
                ||..|..:..|.|:..    :|.|:|.:                       .|.|..:...
 Worm   683 QGYHAIMRAIEDSGQPVLWA----DENKHSAVIQGELQFNQNQHGIEVIEQFLQNIKSTIGEYER 743

  Fly   582 PSQVVTLKVIAPRQQKPT--------------------GLMSIATKVVIQ--------------- 611
            ..:|:...|.|..|.:.|                    ....|.|:.:::
 Worm   744 DGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYLADNKYGIHTQGILEKSLGVVGPSPKNCAL 808

  Fly   612 ---MNAKLMG---------------APWQVVI-PLHGLMTVGFDVCHSPKNKNKSYGAFVATM-- 655
               |..|::|               ..|.:.. |....:.:|.||.| |..:::..|..:..|
 Worm   809 TRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAKPTLVLGIDVSH-PSTRDRETGNVLQKMSA 872

  Fly   656 ---------DQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGD 711
                     |..| ||..|.:.:  .|.|.....|..:...:..:.:.....|..|:.:|||:.:
 Worm   873 ATVVGNIDLDVTE-FRASSRIQD--TGVECLIDFSKEIDERIGEFIDHTGKRPAHIVVYRDGLSE 934

  Fly   712 GQLYQVVNSEVNTLKDR---LDEIYKSAGKQEGCRMTFIIVSKRINSRYF-----TGHR----NP 764
            |...:.:..|...:::|   :|..::.:       :|:|:|:||.::::|     .|:.    |.
 Worm   935 GDFQKYLFEERVCIEERCLKIDTSFQPS-------ITYIVVTKRHHTQFFLEDPSQGYESQGYNV 992

  Fly   765 VPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKL-QMLSYKMTHMYYNYS 828
            :|||:::|.:|..:.|||||.:|....|...||.|.|:.|......|.. ..:::.:|:.:...:
 Worm   993 LPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGKPDSFWPTVTHALTYNFCRST 1057

  Fly   829 GTIRVPAVCHYAHKLAFLVAESINRAPSAGLQNQLY 864
            .|:.:||...|||..|....|:::...:....|.:|
 Worm  1058 TTVALPAPVLYAHLAAKRAKETLDGINTYKSVNNIY 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	32/151 (21%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	108/565 (19%)
ergo-1	NP_503362.2	PAZ	421..557	CDD:198017	33/145 (23%)
		Piwi_ago-like	588..1080	CDD:240015	102/525 (19%)