Protein Alignment aub and wago-1

DIOPT Version :10

• Sequence 1: NP_476734.1
• Gene: aub / 34524
• FlyBaseID: FBgn0000146
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_492045.1
• Gene: wago-1 / 172463
• WormBaseID: WBGene00011061
• Length: 945
• Species: Caenorhabditis elegans
• Alignment Length: 956
• Identity: 176/956 - (18%)
• Similarity: 350/956 - (36%)
• Gaps: 232/956 - (24%)

  Fly    69 AVQMHKSEGDPRGSVRGRRLITD---LVYSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQ 130
            |.::|:|.|:.....|.::|..:   .:|.:|    ::.|.:|..:.:|.|.|.:......|:::
 Worm    35 AQKLHQSTGNDACIKRLQQLNVEDGAKMYMKP----TEPGKMGRPVDIQTNVFGIEVTKETTVHR 95

  Fly   131 YRV----DFTPDVEATRLRRS-----------------FLYEHKG-----ILGG--YIFDG---- 163
            :.|    |.|...|.|..::.                 ||...|.     :..|  .::||
 Worm    96 FMVHAKADLTSTKEVTFTKKGKEDFVVQDRRDKCCNIFFLAVEKNPEFFKMKDGNQIVYDGQSTL 160

  Fly   164 ---TNMF-----------------------------CIN-QFKAVQDSPYVL--ELVTKSRAGEN 193
               .|:|                             ||: :..|.:|:...|  |.:.|..|.:|
 Worm   161 YTTVNLFSELDANGTKSKVFQINGADTGNDDLKTLPCISLEIYAPRDNSITLSSENLGKRTADQN 225

  Fly   194 IEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINL-----ENFRM---- 249
            ||:          .:.|..|.|.|.|.:..    ::..:|:......|:..     |.|..
 Worm   226 IEV----------NNREYTQFLELALNQHC----VRETNRFGCFEHGKVYFLNATEEGFDQRDCV 276

  Fly   250 ------QLWPGYQTSI--------RQHENDILLCSEICHKVMRTETLYNILSDAI-RDSDDYQST 299
                  ||:||.:.:|        |...|..|:...:.....:.:|:...|.|.. :|..:..:.
 Worm   277 DVGDGKQLYPGLKKTIQFIEGPYGRGQNNPSLVIDGMKAAFHKEQTVIQKLFDITGQDPSNGLNN 341

  Fly   300 FKR-----AVMGMVILTDYNNKT--YRIDDVDFQSTPLCKFKTNDGE-ISYVDYYKKRYNIIIRD 356
            ..|     .:.|:...:.|.|:.  .||:.:..:|....:|:..||: .|..:||..:|.|.::.
 Worm   342 MTREKAAAVIKGLDCYSTYTNRKRHLRIEGIFHESATKTRFELPDGKTCSIAEYYADKYKISLQY 406

  Fly   357 LKQPLVMSRPTDKNIRGGNDQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLR 421
            ....||:.:.     ||.|:.....:..::|...:|...:...::.:...|...| ||.| :|:.
 Worm   407 PNANLVVCKD-----RGNNNYFPAELMTVSRNQRVTIPQQTGNQSQKTTKECAVL-PDVR-QRMI 464

  Fly   422 MFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEFRTCSM 486
            :..|...:.....|.|.:..|::.|..:.:.||.|..:::::  |:..:.|
 Worm   465 ITGKNAVNITLENELLVALGIKVYSEPLMVQARELDGKELVY--QRSVMSD-------------- 513

  Fly   487 FKNVHINRW-----YVITPSR-----------------NLRETQEFVQMCIRTASSMKMNICNPI 529
                 :.:|     :.:.|:.                 ::.:..:.|.|.|.:.....|.|..|.
 Worm   514 -----MGKWRAPPGWFVKPATVPDLWAAYAVGNPGCRFSIGDVNQLVGMFIDSCKKKGMVIKPPC 573

  Fly   530 YEEIPDDRNGTYS-----QAIDNAAANDPQIVMVVMRSP---NEEKYSCIKKRTCVDRPVPSQVV 586
                   ..|.||     ..::..||:..:.|:::....   ..::|..:::||.:      .|.
 Worm   574 -------ETGLYSTEKIMTQLEKVAASKCKYVLMITDDAIVHLHKQYKALEQRTMM------IVQ 625

  Fly   587 TLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGL----MTVGFDVCHSP------ 641
            .:|:.........|.......::.:.|.||.|..:.|......:    :.:|..|...|
 Worm   626 DMKISKANAVVKDGKRLTLENIINKTNVKLGGLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYM 690

  Fly   642 -KNK---NKSYGAFVATMDQKESFRYFSTVNEHI---KGQELSEQMSVNMACALRSYQEQHRSLP 699
             .||   |.....|.:.......|     |.:.:   .||:....:...:..::..:::..::||
 Worm   691 MDNKGHLNPQIIGFASNAVANHEF-----VGDFVLAPSGQDTMASIEDVLQNSIDLFEKNRKALP 750

  Fly   700 ERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYF-----T 759
            :||:.:|.|..:|....::..|:...:..:.      |..:..::.||:|:|..:.|:|     :
 Worm   751 KRIIIYRSGASEGSHASILAYEIPLARAIIH------GYSKEIKLIFIVVTKEHSYRFFRDQLRS 809

  Fly   760 GHR----NPVPGTVVDDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKM 820
            |.:    |..||.|:|:.:|.|....|||.......||.....|.|::|:.....|:|:.|::.:
 Worm   810 GGKATEMNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDRLEELTFTL 874

  Fly   821 THMYYNYSGTIRVPAVCHYAHKLA----FLVAESINRAPSAGLQNQ 862
            .|.:...|.:..:|...:.|::.|    .|..|...:.|....::|
 Worm   875 CHHHQIVSLSTSIPTPLYVANEYAKRGRDLWGELTTKGPIEAKESQ 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	PAZ_piwi_like	272..392	CDD:239211	25/128 (20%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	92/508 (18%)
wago-1	NP_492045.1	PAZ_argonaute_like	320..430	CDD:239212	24/114 (21%)
		Piwi	598..905	CDD:214930	62/323 (19%)