DRSC/TRiP Functional Genomics Resources

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Protein Alignment aub and PIWIL4

DIOPT Version :9

Sequence 1:NP_476734.1 Gene:aub / 34524 FlyBaseID:FBgn0000146 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_689644.2 Gene:PIWIL4 / 143689 HGNCID:18444 Length:852 Species:Homo sapiens


Alignment Length:876 Identity:289/876 - (32%)
Similarity:461/876 - (52%) Gaps:51/876 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 RGRGRGRKPNNVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKS 75
            :.||..|.|:..|..|..|..|.:..|.|:   |:||..||..|.:::..: :|..:|:      
Human     8 KARGIARSPSATEVGRIQASPLPRSVDLSN---NEASSSNGFLGTSRISTN-DKYGISS------ 62

  Fly    76 EGD------PRGSVRGRRLITDLVYSRPPGM----TSKKGVVGTHITVQANYFKVLKRPNWTIYQ 130
             ||      .|| |:.::...||.......:    ..|.|..|..:.:..|.|.:....:|.:||
Human    63 -GDAGSTFMERG-VKNKQDFMDLSICTREKLAHVRNCKTGSSGIPVKLVTNLFNLDFPQDWQLYQ 125

  Fly   131 YRVDFTPDVEATRLRRSFLYEHKGILG-GYIFDGTNMFCINQFKAVQDSPYVLELVTKSRAGENI 194
            |.|.:.||:.:.|||.:.||.|..:.. ...|||..:|...:.:     ..|.||.::::.||.|
Human   126 YHVTYIPDLASRRLRIALLYSHSELSNKAKAFDGAILFLSQKLE-----EKVTELSSETQRGETI 185

  Fly   195 EIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSI 259
            ::.|.....:.|:.....||.|:|.|:.::.|.:..:.|.:|:|...:.:...::.||||:..|:
Human   186 KMTITLKRELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHKLSLWPGFAISV 250

  Fly   260 RQHENDILLCSEICHKVMRTETLYNILSDAIRDS--DDYQSTFKRAVMGMVILTDYNNKTYRIDD 322
            ...|..:|..:::.:||:|.||:...::...:.:  ..:..|.::.::|:::||.|||:||.|||
Human   251 SYFERKLLFSADVSYKVLRNETVLEFMTALCQRTGLSCFTQTCEKQLIGLIVLTRYNNRTYSIDD 315

  Fly   323 VDFQSTPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQAIMIIPELA 386
            :|:...|...|:..|| ||:||||||::|:|.:.||.||:::|....|.......|...:||||.
Human   316 IDWSVKPTHTFQKRDGTEITYVDYYKQQYDITVSDLNQPMLVSLLKKKRNDNSEAQLAHLIPELC 380

  Fly   387 RATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIELDSALVEI 451
            ..||:||...:||:.::|::|.|||:|..|.:||......::....:...|::|.:...|. :.:
Human   381 FLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVDNIQRNTNARFELETWGLHFGSQ-ISL 444

  Fly   452 PARVLPPEKILFGNQKIFVCD--ARADWTNEFRTCSMFKNVHINRWYVITPSRNLRETQEFVQMC 514
            ..|::|.||||..:.   :|.  :.|||:.:.|||.:.....:|.|.::...|.....:.|:...
Human   445 TGRIVPSEKILMQDH---ICQPVSAADWSKDIRTCKILNAQSLNTWLILCSDRTEYVAESFLNCL 506

  Fly   515 IRTASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSCIKKRTCVDR 579
            .|.|.||..|:..|...:: .:....:.:||......|.|:||.::.|..:..|..|||....|.
Human   507 RRVAGSMGFNVDYPKIIKV-QENPAAFVRAIQQYVDPDVQLVMCILPSNQKTYYDSIKKYLSSDC 570

  Fly   580 PVPSQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNK 644
            |||||.|..:.:    .|...:||||||:.:||..||.|..|.|.|||..||.||.|||....:|
Human   571 PVPSQCVLARTL----NKQGMMMSIATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDVCKDALSK 631

  Fly   645 NKSYGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGV 709
            :......||:::.:.: |:||.........::::.:.|.|..||..:.:.:..||.||:.:|.||
Human   632 DVMVVGCVASVNPRIT-RWFSRCILQRTMTDVADCLKVFMTGALNKWYKYNHDLPARIIVYRAGV 695

  Fly   710 GDGQLYQVVNSEVNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGH----RNPVPGTVV 770
            |||||..::..||..|   |..:.:|:..... |::.|:|.|:...|:||..    :||..||||
Human   696 GDGQLKTLIEYEVPQL---LSSVAESSSNTSS-RLSVIVVRKKCMPRFFTEMNRTVQNPPLGTVV 756

  Fly   771 DDVITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPA 835
            |...|..|.|||:|:||....||||||.||||.|:.||..|.:|.|::|:.|:|||:.|.:.|||
Human   757 DSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLYYNWPGIVSVPA 821

  Fly   836 VCHYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            .|.|||||.||||:||::.||..|.|.|::|
Human   822 PCQYAHKLTFLVAQSIHKEPSLELANHLFYL 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aubNP_476734.1 ArgoN 105..219 CDD:293095 32/114 (28%)
PAZ_piwi_like 272..392 CDD:239211 45/122 (37%)
Piwi_piwi-like_Euk 400..849 CDD:240016 160/454 (35%)
PIWIL4NP_689644.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 15/42 (36%)
PAZ_piwi_like 270..386 CDD:239211 42/115 (37%)
Piwi_piwi-like_Euk 394..835 CDD:240016 160/454 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147167
Domainoid 1 1.000 113 1.000 Domainoid score I6122
eggNOG 1 0.900 - - E1_KOG1042
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54391
OrthoDB 1 1.010 - - D220258at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100694
Panther 1 1.100 - - O PTHR22891
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X548
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.720

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