DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aub and piwil4

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_012813692.2	Gene:	piwil4 / 100486962	XenbaseID:	XB-GENE-993661	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	874	Identity:	286/874 - (32%)
Similarity:	464/874 - (53%)	Gaps:	55/874 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RGRKPNNVEANRGFAPSLGQ-KSDPSHSEGNQASG-GNGGGGDAQVGPSIEKSSLSAVQMHKSEG 77
            :.::|.....:.|.|..:.. :.|...|:..|..| |||.|.|:.:|      ::||.:......
Frog    13 KNKEPGLARDSPGQASKMSNPRPDAGSSKDLQGIGSGNGSGRDSGIG------TISAGENRYVLA 71

  Fly    78 DPRGSVRGRRLITDLVYSRPPGMT----SKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPD 138
            : ||...||.| .|...:....|.    .|.|..|..:.:..|.|.:.....|.:|||||||:|:
Frog    72 E-RGGRNGRNL-QDFGINTRQTMAHVKDHKTGTSGAPVKLMTNLFGLTLPTQWKLYQYRVDFSPE 134

  Fly   139 VEATRLRRSFLYEHKGILG-GYIFDGTNMFCINQFKAVQDSPYVLELVTKSRAGENIEIKIKAVG 202
            ..:.:|:.:.||.|...|| ...|.|..:|.......:.      .|.:.:|.||.::|.|....
Frog   135 FASRKLKTALLYSHGETLGRARAFHGEILFLSRNIGKLN------HLESTTRKGETVKITITLTN 193

  Fly   203 SVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDIL 267
            .:.:......|...::.::..:.|::..|.|.||:|...:.:...|:.||||:..||.:.|:.:.
Frog   194 QLPADSPVCIQFFGILFKKVFKSLNMYQVGRNYYNPADPVIIPQHRLMLWPGFVLSIMKLESQLA 258

  Fly   268 LCSEICHKVMRTETLYNILSDAIR------DSDDYQSTFKRAVMGMVILTDYNNKTYRIDDVDFQ 326
            ||:::.|||:|.||:.    |:::      ..:.:....::.::|:|:||.|||||||:||:|:.
Frog   259 LCADVSHKVLRNETVL----DSMKALYSKVPKERFTDICEKELLGLVVLTRYNNKTYRVDDIDWS 319

  Fly   327 STPLCKFKTNDG-EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGN---DQAIMIIPELAR 387
            :.|...|...|| ||:|.|||.::|:|.|.||:||:::|  |.|..:..|   .:|:.:||||..
Frog   320 TKPTDSFPRKDGSEITYTDYYSQQYSINISDLQQPMLVS--TLKAKKSDNPDAPRAVHLIPELCY 382

  Fly   388 ATGMTDAMRADFRTLRAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIELDSALVEIP 452
            .||::....:|||.::.:|..|:|:|:||.:||:.....::...::...|:.|.:.:|.. :.:.
Frog   383 LTGLSSRALSDFRLMKDLSMETQLDPERRQQRLQRLADSIQRTPEASAELEKWGLRMDKQ-IPVT 446

  Fly   453 ARVLPPEKILFGNQKIFVCDARADWTNEFRTCSMFKNVHINRWYVITPSRNLRETQEFVQMCIRT 517
            .|:.|||:| |....:....:.|||..:.|...:.....:..|.::...||....:..:|..::.
Frog   447 GRIAPPERI-FMRDNVCTPGSPADWARDTRNEKVICVAPLQNWLMLFSYRNADVAENLLQCLMKV 510

  Fly   518 ASSMKMNICNPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSCIKKRTCVDRPVP 582
            ||.|..::..|...:: :|...::.:.:......|.|:|..|:.:..::.|..|||...:|:|||
Frog   511 ASGMGFHMDMPRIVQV-EDNPVSFLRTLQKNVTPDLQLVFCVIPTNQKDSYDSIKKFLSLDQPVP 574

  Fly   583 SQVVTLKVIAPRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKS 647
            ||.|..:.:. |||.   :||:|.|:.:||..||.|..|.|.|||..||.||.|:.....||:.|
Frog   575 SQCVQNRTLG-RQQM---MMSVANKIAMQMICKLGGELWAVEIPLKALMVVGIDINKDAVNKSMS 635

  Fly   648 YGAFVATMDQKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDG 712
            ...|||:.:.:.: |:.|.........:.::.:.:.|..|::::|..:..||.||:.:|||||||
Frog   636 VVGFVASTNARLT-RWHSRCIIQKTTSDFADCLKMCMKGAIQNWQRCNNDLPNRIVVYRDGVGDG 699

  Fly   713 QLYQVVNSEVNTLKDRLDEIYKSAGKQEGC-RMTFIIVSKRINSRYFT----GHRNPVPGTVVDD 772
            ||..||:.|:..|.....|.     |...| |::.|:|.|:..||::|    |.:|||.||:||.
Frog   700 QLKMVVDYEIPQLLSSFRET-----KTSYCPRLSVIVVRKKCISRFYTQTGRGIQNPVLGTIVDS 759

  Fly   773 VITLPERYDFFLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVC 837
            ..|.||.|||:|:||..|.|||:||.|||:.|..||..|.:|.|:||:.|:|||:.|.|||||.|
Frog   760 EATRPEWYDFYLISQNARQGTVNPTYYNVLLDENGLKPDHMQRLTYKLCHLYYNWPGVIRVPAPC 824

  Fly   838 HYAHKLAFLVAESINRAPSAGLQNQLYFL 866
            .|||||.|||.:||:|.||..|.::|::|
Frog   825 QYAHKLTFLVGQSIHREPSPELSHKLFYL 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	29/114 (25%)
		PAZ_piwi_like	272..392	CDD:239211	49/129 (38%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	159/453 (35%)
piwil4	XP_012813692.2	ArgoL1	221..267	CDD:400854	16/45 (36%)
		PAZ	271..409	CDD:198017	51/143 (36%)
		Piwi_piwi-like_Euk	395..836	CDD:240016	159/453 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030