DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aub and piwil2

DIOPT Version :9

Sequence 1:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_012813952.1	Gene:	piwil2 / 100127654	XenbaseID:	XB-GENE-982236	Length:	960	Species:	Xenopus tropicalis

Alignment Length:	920	Identity:	288/920 - (31%)
Similarity:	471/920 - (51%)	Gaps:	97/920 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PVIARGRGRGRKPNNVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVG-PSIEKSSLSAV 70
            |.:.||.|...||:.:....|          |....|..::..:|.|.|..:. |||..|..:.|
Frog    78 PALFRGMGIETKPSGIPGRGG----------PVFGRGFLSTMSSGDGPDQPLSEPSIRPSLSTRV 132

  Fly    71 QMHKSEGDPRGSV-RGRRLITDLVYSRP--------------PGMTS------------------ 102
            |........|.:: |.|..|..:...:|              |.:||
Frog   133 QQASDFSTERVALGRARFPIPPVSMEKPHVPTGRGLLFPSVLPTLTSDPVPKESPIATLQIEKEE 197

  Fly   103 ------KKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGGY-I 160
                  |||..|:...:..|..|: ...|..:|||.|.|||.||...:|...:.:|:.:.|.. .
Frog   198 KWEPLPKKGSKGSPCQLGLNLIKI-NFQNEAVYQYHVTFTPIVECRSMRFGMMKDHRSVTGPVTA 261

  Fly   161 FDGTNMFCINQFKAVQDSPYVLELVTKSRA-GENIEIKIKAVGSVQSTDAEQFQVLNLILRRAME 224
            |||:.::.  ..|..|    .:||.::.|. |:.|:|.|:....:..:........|:::||..:
Frog   262 FDGSILYL--PVKLAQ----TVELESERRTDGQKIKITIQMTKILDPSSDLCLPFYNVVMRRVFK 320

  Fly   225 GLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDA 289
            .||||||.|.:|||.:...|:.:|:|:||||..:||:.:..:.|..:|.||::|::::.:|::..
Frog   321 ILDLKLVGRNFYDPASSTVLQQYRLQVWPGYAANIRKTDGGLFLLVDITHKIIRSDSVLDIMNIL 385

  Fly   290 IRDS-DDYQSTFKRAVMGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG-EISYVDYYKKRYNI 352
            .:.| :::|....:.::|.:::|.|||:||||||:::..:|...|..:|| ::|::|||.|.|.|
Frog   386 YQQSPENFQDEVTKQLVGSIVITRYNNRTYRIDDIEWNMSPKDSFSMSDGSKVSFIDYYSKNYGI 450

  Fly   353 IIRDLKQPLVMSRPTDKNI-RGGNDQAIMIIPELARATGMTDAMRADFRTLRAMSEHTRLNPDRR 416
            .:::|.|||::.||:::.. :|.....::::||||..||:.:.||.|||.::.:::...|:|.:.
Frog   451 TVKELDQPLLLHRPSERKAPKGKALDIVLLLPELAFMTGIPEKMRKDFRAMKDLTQQIHLSPKQH 515

  Fly   417 IERLRMFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQKIFVCDARADWTNEF 481
            ...|....||::|...:...|:.|.:.||:.:.....|:||.|||...|.. |......:|..|.
Frog   516 HISLGKLLKRIESSADAKNELQRWGLFLDTDIHMTTGRILPIEKINLRNNS-FPAGEDLNWNREV 579

  Fly   482 RTCSMFKNVHINRWYVITPSRNLRETQEFVQMCIRTASSMKMNICNPIYEEIPDDRNGTYSQAID 546
            ...:...:||:..|.:|.|.|...:.||...|..|....:.:.:.:|...|:.|||..||:::|.
Frog   580 TREACRSSVHLLYWAMIYPKRASAQAQELSSMLERIGGPIGIRVNHPNCVELRDDRVETYARSIK 644

  Fly   547 NAAAND--PQIVMVVMRSPNEEKYSCIKKRTCVDRPVPSQVVTLKVIAPRQQKPTGLMSIATKVV 609
            :....:  .|:::.::....::.|..|||..||..||||||:..:.|:    :|..|.|||.|::
Frog   645 SLLEGEGKVQLLVCLISGTRDDLYGAIKKLCCVQNPVPSQVINTRTIS----QPQKLRSIAQKIL 705

  Fly   610 IQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKSYGAFVATMDQKESFRYFSTVNEHIKGQ 674
            :|:|.||.|..|.|.|||..:|.:|.||.|.|....:|...|||:::...: .::|.|...:..|
Frog   706 LQINCKLGGELWGVDIPLKSVMVIGMDVYHDPSRGMRSVLGFVASINSCLT-AWYSRVVFQLPNQ 769

  Fly   675 ELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSEVNTLKDRLDEIYKSAGKQ 739
            |:.:.:.:.:..||:.:.|.:.||||:|:.:||||.||||..|.|.|:..|
Frog   770 EIMDSLKLCLVAALQKFFEVNHSLPEKIVVYRDGVSDGQLNTVENYEIPQL-------------- 820

  Fly   740 EGC---------RMTFIIVSKRINSRYF---TGH-RNPVPGTVVDDVITLPERYDFFLVSQAVRI 791
            :.|         ||..|:|.||:::..:   ||. ..|.||||:|..:|..:..||||:|..||.
Frog   821 QTCFQTFDNYNPRMVVIVVQKRVSTNLYSTATGQFLTPQPGTVIDHTVTNRKWIDFFLMSHHVRQ 885

  Fly   792 GTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAFLVAESINRAPS 856
            |...||.|..:.:...|..|.||.|::|:.|||:|:.|||||||.|.||||||||..:.::..||
Frog   886 GCGIPTHYICVMNTANLGPDHLQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGQFLHHEPS 950

  Fly   857 AGLQNQLYFL 866
            ..|.::|:||
Frog   951 IKLCDKLFFL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aub	NP_476734.1	ArgoN	105..219	CDD:293095	30/115 (26%)
		PAZ_piwi_like	272..392	CDD:239211	42/122 (34%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	156/463 (34%)
piwil2	XP_012813952.1	ArgoN	203..304	CDD:293095	31/107 (29%)
		ArgoL1	327..374	CDD:285861	18/46 (39%)
		PAZ	376..513	CDD:198017	44/136 (32%)
		Piwi_piwi-like_Euk	499..943	CDD:240016	156/463 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6335
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3665
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960