DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and AGO7

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_177103.1	Gene:	AGO7 / 843276	AraportID:	AT1G69440	Length:	990	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	182/855 - (21%)
Similarity:	362/855 - (42%)	Gaps:	184/855 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 AELVSKK----GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEF--EPSIENPR-VRMGVLSNHANL 141
            |.:|:|:    |.||..:.|..|.|.:|.....||.||:||.  :||.|..| ::..::....|.
plant   147 ALVVAKRPDFGGQDGSVIYLLANHFLVKFDSSQRIYHYNVEISPQPSKEIARMIKQKLVETDRNS 211

  Fly   142 LGSGYL--FDGLQ-LFTTRKFEQE-------ITVLSGKS--------------KLDIEYKISIKF 182
            . ||.:  |||.| :::..:|:.:       :.:.|.|:              |::..:::::|.
plant   212 F-SGVVPAFDGRQNIYSPVEFQGDRLEFFVNLPIPSCKAVMNYGDLREKQPQKKIEKLFRVNMKL 275

  Fly   183 VGFISCAE------------PRFLQVLNLILRRS-MKGLNLELVGRNLFDPR---------AKIE 225
            |......|            |.::..|::|||.: |:  ....:||:.:...         ..:.
plant   276 VSKFDGKEQRKEGEDWAPLPPEYIHALDVILRENPME--KCTSIGRSFYSSSMGGSKEIGGGAVG 338

  Fly   226 IREFKMELWPGYETSIRQHEKDILLGTEIT----HKVM--------RTETIYDIM----RRCSHN 274
            :|        |:..|:|..::.:.|..:::    |:.:        |.|.:.|:.    |..|..
plant   339 LR--------GFFQSLRHTQQGLALNMDLSITAFHESIGVIAYLQKRLEFLTDLPRNKGRELSLE 395

  Fly   275 PARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSC-----KGRDISFVEYYLTKYNI 334
            ..|..::...|:...:...:...| ||:    :|.|.:.|.:.     :|:.:..:.|:...|..
plant   396 EKREVEKALKNIRVFVCHRETVQR-YRV----YGLTEEITENIWFPDREGKYLRLMSYFKDHYGY 455

  Fly   335 RIRDHNQPLL-ISKNRDKALKTNASELVVLIPELCRVTGLNAEMR------SNFQLMRAMSSYTR 392
            .|:..|.|.| ||:.|.          ..|..|||.:    .|.:      |:.|..:.|    :
plant   456 EIQFKNLPCLQISRARP----------CYLPMELCMI----CEGQKFLGKLSDDQAAKIM----K 502

  Fly   393 MNPKQRTDRLRAFNHRLQNT--PESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGEN 455
            |..::..:|....:..:..:  |.|....|::|:|:.:.:|.::|||:....:     |:....|
plant   503 MGCQKPNERKAIIDKVMTGSVGPSSGNQTREFNLEVSREMTLLKGRILQPPKL-----KLDRPRN 562

  Fly   456 ADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTL---LDSLYRAASGMGLRIRSPQEFIIY 517
            ....:.|:..|        ::|||:::...:|.:..|:   ::.|.:....:|:       |:..
plant   563 LKESKVFKGTR--------IERWALMSIGGSSDQKSTIPKFINELTQKCEHLGV-------FLSK 612

  Fly   518 DDRTGTY----------------VRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPT 566
            :..:.|:                ::.:.....::.:||:|::...: :.|..:|:.......|.|
plant   613 NTLSSTFFEPSHILNNISLLESKLKEIQRAASNNLQLIICVMEKKH-KGYGDLKRISETRIGVVT 676

  Fly   567 QVVTL-KTTKNRSLMSIATKIAIQLNCKLGYTPWMIEL-------------PLSGLMTIGFDIA- 616
            |.... ..||..|  ...:.:|:::|.|:|.:  |.||             |...::.:|.|:.
plant   677 QCCLYPNITKLSS--QFVSNLALKINAKIGGS--MTELYNSIPSHIPRLLRPDEPVIFMGADVTH 737

  Fly   617 -KSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRI 680
             ....|...:..|::.|::..:.:.|.|.:...:....:...|..|:.:.|..:....:|||:||
plant   738 PHPFDDCSPSVAAVVGSINWPEANRYVSRMRSQTHRQEIIQDLDLMVKELLDDFYKAVKKLPNRI 802

  Fly   681 VFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFL---NGQNPP 742
            :|:|||||....|::.:.|    ::.:||..::.|...|.:.:.||.:..:||.|.   :.:|.|
plant   803 IFFRDGVSETQFKKVLQEE----LQSIKTACSKFQDYNPSITFAVVQKRHHTRLFRCDPDHENIP 863

  Fly   743 PGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGT 807
            |||:||.|||.|:.:||||.|....:||..||.|::|:.....:.:::|:|.|.:|:.:...:..
plant   864 PGTVVDTVITHPKEFDFYLCSHLGVKGTSRPTHYHILWDENEFTSDELQRLVYNLCYTFVRCTKP 928

  Fly   808 TRVPAVCQYA 817
            ..:.....||
plant   929 ISIVPPAYYA 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	33/148 (22%)
		PAZ	262..396	CDD:198017	31/149 (21%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	105/476 (22%)
AGO7	NP_177103.1	ArgoN	220..306	CDD:406799	12/85 (14%)
		ArgoL1	316..366	CDD:400854	7/57 (12%)
		PAZ	390..495	CDD:396648	26/123 (21%)
		Piwi_ago-like	532..949	CDD:240015	99/436 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.880