DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and AGO6

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_180853.2	Gene:	AGO6 / 817856	AraportID:	AT2G32940	Length:	878	Species:	Arabidopsis thaliana

Alignment Length:	924	Identity:	192/924 - (20%)
Similarity:	331/924 - (35%)	Gaps:	242/924 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTK-PEWRIVHYHVEFEPSIEN------ 127
            :|....||....|..      ||.|.|:.|.||.|.:..: |:  :|.|......:.||
plant    18 QPSHRDYDITTRRGV------GTTGNPIELCTNHFNVSVRQPD--VVFYQYTVSITTENGDAVDG 74

  Fly   128 ---PRVRMGVL--SNHANLLGSGYLFDGLQ-LFTTRKFEQE----ITVLSG-------------- 168
               .|..|..|  :..::|.|....:||.: |:|.....|.    :.::.|
plant    75 TGISRKLMDQLFKTYSSDLDGKRLAYDGEKTLYTVGPLPQNEFDFLVIVEGSFSKRDCGVSDGGS 139

  Fly   169 ---------KSKLDIEYKISIKFVGFISC---------------AEPRFLQVLNLILRRSMKGLN 209
                     :|.|...||:.|.:...|..               :....|:||:::||:......
plant   140 SSGTCKRSKRSFLPRSYKVQIHYAAEIPLKTVLGTQRGAYTPDKSAQDALRVLDIVLRQQAAERG 204

  Fly   210 LELVGRNLFDPRAK--------IEIREFKMELWPGYETSIRQHEKDILLGTEI-THKVMRTETIY 265
            ..||.:..|.....        |.||        |..:|.|.....:.|..:: |..::....:.
plant   205 CLLVRQAFFHSDGHPMKVGGGVIGIR--------GLHSSFRPTHGGLSLNIDVSTTMILEPGPVI 261

  Fly   266 DIMR-RCSHNPARHQDEVRVNVL--DLIVLTDYNNRTYRINDVDFGQTPKSTFSCKGRD------ 321
            :.:: ..|....|..|.::...:  .:.|...:.|..::|..:......:..||.|.:|
plant   262 EFLKANQSVETPRQIDWIKAAKMLKHMRVKATHRNMEFKIIGLSSKPCNQQLFSMKIKDGEREVP 326

  Fly   322 ---ISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQL 383
               |:..:|:...|...|.....|.|   :..|..:.|...|     |.|.:..|
plant   327 IREITVYDYFKQTYTEPISSAYFPCL---DVGKPDRPNYLPL-----EFCNLVSL---------- 373

  Fly   384 MRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRD---------------WNMELDKNVTEV 433
                ..||:  |.....|:.......|...|.:|.|.|               ..:.::|.:|:|
plant   374 ----QRYTK--PLSGRQRVLLVESSRQKPLERIKTLNDAMHTYCYDKDPFLAGCGISIEKEMTQV 432

  Fly   434 QGRIIGQQNIVFHNGKVPAGENADWQ----RHFRDQRMLTTPSDGLDRWAVI---APQRNSHELR 491
            :||::....:.|       |:|.|:|    |...:.:||..|. .:..||::   .|..:||..|
plant   433 EGRVLKPPMLKF-------GKNEDFQPCNGRWNFNNKMLLEPR-AIKSWAIVNFSFPCDSSHISR 489

  Fly   492 TLLDSLYRAASGM--GLRIRSPQEFIIYD---------DRTGTYVRAMDDCVRSDPKLILCLVP- 544
            .|:      :.||  |:.|..|...:..|         :|....:..|.......|..|||::|
plant   490 ELI------SCGMRKGIEIDRPFALVEEDPQYKKAGPVERVEKMIATMKLKFPDPPHFILCILPE 548

  Fly   545 NDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLM 609
            ...::.|...||....:..:.||.:......::.|    |.:.:::|.|||        .::.|:
plant   549 RKTSDIYGPWKKICLTEEGIHTQCICPIKISDQYL----TNVLLKINSKLG--------GINSLL 601

  Fly   610 TIGFDIAKSTRDRKRAYG--------ALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAK-- 664
            .|.:           :|.        .||..||:.......:.|...:|  |:.:..||:|::
plant   602 GIEY-----------SYNIPLINKIPTLILGMDVSHGPPGRADVPSVAA--VVGSKCWPLISRYR 653

  Fly   665 -ALRQ---------------------------------YQHEHRKLPSRIVFYRDGVSSGSLKQL 695
             |:|.                                 |:....:.|.:|:.:|||||....:|:
plant   654 AAVRTQSPRLEMIDSLFQPIENTEKGDNGIMNELFVEFYRTSRARKPKQIIIFRDGVSESQFEQV 718

  Fly   696 FEFEVKDIIEKLKTEYARV-QLSPPQLAYIVVTRSMNTRFF--LNGQNPPPGTIVDDVITLPERY 757
            .:.||..||:    .|.|: :...|:...||..::.:|:.|  ...:|.|.||:||..|..|..|
plant   719 LKIEVDQIIK----AYQRLGESDVPKFTVIVAQKNHHTKLFQAKGPENVPAGTVVDTKIVHPTNY 779

  Fly   758 DFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLAT 822
            |||:.:...:.||..|..|:||...:|.||:.:|.|.:.:.::....:..|.:.|..:||...|.
plant   780 DFYMCAHAGKIGTSRPAHYHVLLDEIGFSPDDLQNLIHSLSYVNQRSTTATSIVAPVRYAHLAAA 844

  Fly   823 LVG--TNLHSIPQN 834
            .|.  |....|.::
plant   845 QVAQFTKFEGISED 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	33/164 (20%)
		PAZ	262..396	CDD:198017	24/145 (17%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	118/526 (22%)
AGO6	NP_180853.2	PLN03202	15..878	CDD:215631	192/924 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.880