DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and AGO4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001189613.1	Gene:	AGO4 / 817246	AraportID:	AT2G27040	Length:	924	Species:	Arabidopsis thaliana

Alignment Length:	953	Identity:	203/953 - (21%)
Similarity:	372/953 - (39%)	Gaps:	225/953 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SGDGPRVKVFRGSS-SG--------DPRADPRIEASRERRALEEAPRREGGPTERKPWGDQYDYL 79
            :|:|..::...|:: ||        .|...|.:|..|.:..|.|.......|..||.:
plant     5 NGNGADLESANGANGSGVTEALPPPPPVIPPNVEPVRVKTELAEKKGPVRVPMARKGF------- 62

  Fly    80 NTRPAELVSKKGTDGVPVMLQTNFFRLK-TKPEWRIVHYHVEFEPSIENPRVRMGV--------- 134
                       ||.|..:.|.||.|::. ...:....||.|........|..:.||
plant    63 -----------GTRGQKIPLLTNHFKVDVANLQGHFFHYSVALFYDDGRPVEQKGVGRKILDKVH 116

  Fly   135 LSNHANLLGSGYLFDGLQ-LFT-----TRKFE-----QEITVL---------------------- 166
            .:.|::|.|..:.:||.: |||     :.|.:     :|::..
plant   117 QTYHSDLDGKEFAYDGEKTLFTYGALPSNKMDFSVVLEEVSATRANGNGSPNGNESPSDGDRKRL 181

  Fly   167 -----SGKSKLDIEY--KISIKFV-----GFISCAEPRFLQVLNLILRR--SMKG---------- 207
                 |...:::|.|  ||.::.:     |..|......::||::|||:  :.:|
plant   182 RRPNRSKNFRVEISYAAKIPLQALANAMRGQESENSQEAIRVLDIILRQHAARQGCLLVRQSFFH 246

  Fly   208 ---LNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEI-THKVMRTETIYDIM 268
               .|.|.||.|:...|              |:.:|.|..:..:.|..:: |..:::...:.|.:
plant   247 NDPTNCEPVGGNILGCR--------------GFHSSFRTTQGGMSLNMDVTTTMIIKPGPVVDFL 297

  Fly   269 RRCSHNPARHQ-----DEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCKGR-------- 320
              .::..||..     .:.:..:.:|.|....:.:.::|..:......:.||..|.|
plant   298 --IANQNARDPYSIDWSKAKRTLKNLRVKVSPSGQEFKITGLSDKPCREQTFELKKRNPNENGEF 360

  Fly   321 ---DISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVT-GLNAEMRSNF 381
               :::..:|:....:|.::.......|:..:.|.......||..|:| |.|.| .|....||
plant   361 ETTEVTVADYFRDTRHIDLQYSADLPCINVGKPKRPTYIPLELCALVP-LQRYTKALTTFQRS-- 422

  Fly   382 QLMRAMSSYTRMNPKQR----TDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQN 442
                |:...:|..|::|    :..|:..|:      ::..:||...:.:..|.|:|:||::....
plant   423 ----ALVEKSRQKPQERMTVLSKALKVSNY------DAEPLLRSCGISISSNFTQVEGRVLPAPK 477

  Fly   443 IVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLR 507
            :....|......|..|  :|.::..:....  :.||.|:......: :|.::|.|.:.....|:.
plant   478 LKMGCGSETFPRNGRW--NFNNKEFVEPTK--IQRWVVVNFSARCN-VRQVVDDLIKIGGSKGIE 537

  Fly   508 IRSPQEFIIYDDRTGTYVRAMDDCVRSD-------------PKLILCLVPN-DNAERYSSIKKRG 558
            |.||  |.::::  |...|.....:|.:             |:.|||::|: .|::.|...||:.
plant   538 IASP--FQVFEE--GNQFRRAPPMIRVENMFKDIQSKLPGVPQFILCVLPDKKNSDLYGPWKKKN 598

  Fly   559 YVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRK 623
            ..:..:.||.:......|...:   |.:.:::|.|||....|:.:..:...|:   |:|
plant   599 LTEFGIVTQCMAPTRQPNDQYL---TNLLLKINAKLGGLNSMLSVERTPAFTV---ISK------ 651

  Fly   624 RAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAK---ALRQ----------------- 668
              ...:|..||:...|...|.|...:|  |:::..||:|:|   ::|.
plant   652 --VPTIILGMDVSHGSPGQSDVPSIAA--VVSSREWPLISKYRASVRTQPSKAEMIESLVKKNGT 712

  Fly   669 -------------YQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLSPPQ 720
                         |...:::.|..|:.:|||||.....|:...|:..|||..|...|...   |:
plant   713 EDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACKLLDANWN---PK 774

  Fly   721 LAYIVVTRSMNTRFF--LNGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSM 783
            ...:|..::.:|:||  .:.:|.|||||:|:.|..|:..||||.:.....||..||.|:|||..:
plant   775 FLLLVAQKNHHTKFFQPTSPENVPPGTIIDNKICHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEI 839

  Fly   784 GLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGT 826
            |.|.:::|:|.:.:.::|...:....|.|...||...|..:||
plant   840 GFSADELQELVHSLSYVYQRSTSAISVVAPICYAHLAAAQLGT 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	32/164 (20%)
		PAZ	262..396	CDD:198017	26/150 (17%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	116/496 (23%)
AGO4	NP_001189613.1	PLN03202	45..924	CDD:215631	194/913 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870