DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and Piwil4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_008764202.1	Gene:	Piwil4 / 689972	RGDID:	1311015	Length:	848	Species:	Rattus norvegicus

Alignment Length:	872	Identity:	288/872 - (33%)
Similarity:	455/872 - (52%)	Gaps:	60/872 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPR-----------IEASRERRALEEA 59
            ||.|.|........::|.....||..:....|.||..|..|           :.:...||.|.|
  Rat     3 GRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRTSVISQPHELGVSSGDGRRTLVE- 66

  Fly    60 PRREGGPTERKPWGDQYDYLN----TRPAELV----SKKGTDGVPVMLQTNFFRLKTKPEWRIVH 116
             :|..|         :.|:::    || .:|.    ||.|:.|:||.|.||.|.|....:|::..
  Rat    67 -KRGNG---------RQDFVDLGVCTR-EKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQ 120

  Fly   117 YHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIK 181
            |||.:.|.:.:.|:|..:|.||:.|......|||..||.:.|.:.::|.|:.:::.....||::.
  Rat   121 YHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLT 185

  Fly   182 FVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEK 246
            ....:....|..:|..|:|.|:..|.|::..:|||.:.|...:||.::|:.||||:..|:.:.|.
  Rat   186 LTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFES 250

  Fly   247 DILLGTEITHKVMRTETIYDIM--------RRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRIN 303
            .:|...::.:||:|.||:.:.|        ..|.......|      ::.|||||.|||:||||:
  Rat   251 KLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQ------LVGLIVLTRYNNKTYRID 309

  Fly   304 DVDFGQTPKSTFSCK-GRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPEL 367
            |:|:...|...|..: |.:.::|:||..:|:|.:.|.|||:|:|..:.:....:..::|.|||||
  Rat   310 DIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPEL 374

  Fly   368 CRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTE 432
            |.:|||.::..|:|:||:|::..||::|..|..:|......:|....:...|..|.:.....::
  Rat   375 CFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLS- 438

  Fly   433 VQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSL 497
            :.||::..:.|:..:........|||.:..|..::|:  |:.|:.|.::...|..|.:.:.|..|
  Rat   439 LTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLS--SEPLNTWLIVCCSRAEHLIESFLSCL 501

  Fly   498 YRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDR 562
            .|.....|..:..| :.|..|:....::||:...|..|.:|::|::|::....|.|||:....|.
  Rat   502 RRVGGSTGFSVGHP-KIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDC 565

  Fly   563 AVPTQVVTLKTTKNRSLM-SIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAY 626
            .||:|.|..:|...:.:| |:|||||:|:.||||...|.:|:||..||.:|.||.:....:..|.
  Rat   566 PVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAV 630

  Fly   627 GALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQ-YQHEHRKLPSRIVFYRDGVSSG 690
            ...:||::.:....:...|.:.:|.|: |:.|...:..||.: |:|.| .||:||:.|||||.:|
  Rat   631 VGFVASINSRITRWFSRCVLQRTAADI-ADCLKVCMTGALNKWYKHNH-DLPARIIAYRDGVGNG 693

  Fly   691 SLKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNG----QNPPPGTIVDDVI 751
            .||.:.|:||..::..: ||......| .:|:.:||.:....|.|...    ||||.||:||...
  Rat   694 QLKAVLEYEVPQLLSSV-TECGSDARS-CRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEA 756

  Fly   752 TLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQY 816
            |.||.|||||.||...:||||||.|||:|....|.|:.||:||:|:|||||||.|...|||.|||
  Rat   757 TRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQY 821

  Fly   817 AKKLATLVGTNLHSIPQNALEKKFYYL 843
            |.||..||..::|..|...|..|.:||
  Rat   822 AHKLTFLVAQSIHKEPSLELANKLFYL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	33/109 (30%)
		PAZ	262..396	CDD:198017	50/142 (35%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	159/449 (35%)
Piwil4	XP_008764202.1	ArgoN	95..205	CDD:293095	33/109 (30%)
		PAZ_piwi_like	265..381	CDD:239211	42/121 (35%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	159/449 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340832
Domainoid	1	1.000	130	1.000	Domainoid score	I5077
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720