DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment piwi and PIWIL2

DIOPT Version :9

Sequence 1:NP_001285825.1 Gene:piwi / 34521 FlyBaseID:FBgn0004872 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001129193.1 Gene:PIWIL2 / 55124 HGNCID:17644 Length:973 Species:Homo sapiens


Alignment Length:860 Identity:270/860 - (31%)
Similarity:449/860 - (52%) Gaps:70/860 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 RGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPA-- 84
            |||.|...:.:.|.:..          .|||   :::.|.....|:...|      .|::.||  
Human   146 RGSSDASLLPLGRAAGG----------ISRE---VDKPPCTFSTPSRGPP------QLSSPPALP 191

  Fly    85 --------------------ELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPR 129
                                ||:.|:|:.|.|..|..|..:::...| .:..|||.|.|::|...
Human   192 QSPLHSPDRPLVLTVEHKEKELIVKQGSKGTPQSLGLNLVKIQCHNE-AVYQYHVTFSPNVECKS 255

  Fly   130 VRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRFL 194
            :|.|:|.:|..:.|:...|||..|:...|.:|.:.:.|.:.....|..|.|:....:.......:
Human   256 MRFGMLKDHQAVTGNVTAFDGSILYLPVKLQQVLELKSQRKTDSAEISIKIQMTKILEPCSDLCI 320

  Fly   195 QVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVM 259
            ...|::.||.||.|:::|||||.:||.:.:.:::.::::||||..|||:.:..:.|..:::|||:
Human   321 PFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVI 385

  Fly   260 RTETIYDIMRRC-SHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCK-GRDI 322
            |.:.:.|:|... ..|....|||....::..||:|.||||||||:|||:.:|||.:|:.. |::|
Human   386 RNDCVLDVMHAIYQQNKEHFQDECTKLLVGNIVITRYNNRTYRIDDVDWNKTPKDSFTMSDGKEI 450

  Fly   323 SFVEYYLTKYNIRIRDHNQPLLISK------NRDKALKTNASELVVLIPELCRVTGLNAEMRSNF 381
            :|:|||...|.|.:::.:|||||.:      |....||..    ::|:|||..:||:..:|:.:|
Human   451 TFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGE----ILLLPELSFMTGIPEKMKKDF 511

  Fly   382 QLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFH 446
            :.|:.::....::|||....|.....|:.....:...|..|.:.|.|:|.:::||::..:.|...
Human   512 RAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLK 576

  Fly   447 NGKVPAGENADWQRHF-RDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRS 510
            |......:..:|.:.. ||..:||.|   :..||:..|:|...:.|.|::.|.:.|..:|:|:..
Human   577 NTSFITSQELNWVKEVTRDPSILTIP---MHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSP 638

  Fly   511 PQEFIIYDDRTGTYVRAMDDCVRSDPK--LILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKT 573
            |....:.|||..||||.:...:.::.|  :::|::.....:.|.:|||...|...||:|||.::|
Human   639 PAWVELKDDRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRT 703

  Fly   574 T-KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQ 637
            . :...|.|:|.||.:|:|||||...|.:::||..||.||.|:........|:....:||::|..
Human   704 IGQPTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTL 768

  Fly   638 NSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKD 702
            ...|...|.:....::: ::|...:..:|:::...:..||.:||.||||||.|.||.:..:|:..
Human   769 TKWYSRVVFQMPHQEIV-DSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQ 832

  Fly   703 IIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFL----NGQNPPPGTIVDDVITLPERYDFYLVS 763
             ::|....:...|   |::...||.:.::|..:|    |...|.|||:||..||..|..||||::
Human   833 -LQKCFEAFENYQ---PKMVVFVVQKKISTNLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYLLA 893

  Fly   764 QQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNL 828
            ..||||...||.|..:.::..|||:.||:||:|:||:|:||.||.||||.|:||.|||.|.|..|
Human   894 HHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHIL 958

  Fly   829 HSIPQNALEKKFYYL 843
            |..|...|.:..::|
Human   959 HHEPAIQLCENLFFL 973

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
piwiNP_001285825.1 ArgoN 91..201 CDD:293095 28/109 (26%)
PAZ 262..396 CDD:198017 49/141 (35%)
Piwi_piwi-like_Euk 382..826 CDD:240016 147/451 (33%)
PIWIL2NP_001129193.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..65
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..199 9/55 (16%)
ArgoL1 339..386 CDD:312283 17/46 (37%)
PAZ_piwi_like 387..504 CDD:239211 46/120 (38%)
Piwi_piwi-like_Euk 512..956 CDD:240016 147/451 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147178
Domainoid 1 1.000 69 1.000 Domainoid score I9637
eggNOG 1 0.900 - - E1_KOG1042
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54391
OrthoDB 1 1.010 - - D220258at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100694
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X548
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.620

Return to query results.
Submit another query.