Protein Alignment piwi and PIWIL2

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_060538.2
• Gene: PIWIL2 / 55124
• HGNCID: 17644
• Length: 973
• Species: Homo sapiens
• Alignment Length: 860
• Identity: 270/860 - (31%)
• Similarity: 449/860 - (52%)
• Gaps: 70/860 - (8%)

  Fly    22 RGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPA-- 84
            |||.|...:.:.|.:..          .|||   :::.|.....|:...|      .|::.||
Human   146 RGSSDASLLPLGRAAGG----------ISRE---VDKPPCTFSTPSRGPP------QLSSPPALP 191

  Fly    85 --------------------ELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPR 129
                                ||:.|:|:.|.|..|..|..:::...| .:..|||.|.|::|...
Human   192 QSPLHSPDRPLVLTVEHKEKELIVKQGSKGTPQSLGLNLVKIQCHNE-AVYQYHVTFSPNVECKS 255

  Fly   130 VRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRFL 194
            :|.|:|.:|..:.|:...|||..|:...|.:|.:.:.|.:.....|..|.|:....:.......:
Human   256 MRFGMLKDHQAVTGNVTAFDGSILYLPVKLQQVLELKSQRKTDSAEISIKIQMTKILEPCSDLCI 320

  Fly   195 QVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVM 259
            ...|::.||.||.|:::|||||.:||.:.:.:::.::::||||..|||:.:..:.|..:::|||:
Human   321 PFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVI 385

  Fly   260 RTETIYDIMRRC-SHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCK-GRDI 322
            |.:.:.|:|... ..|....|||....::..||:|.||||||||:|||:.:|||.:|:.. |::|
Human   386 RNDCVLDVMHAIYQQNKEHFQDECTKLLVGNIVITRYNNRTYRIDDVDWNKTPKDSFTMSDGKEI 450

  Fly   323 SFVEYYLTKYNIRIRDHNQPLLISK------NRDKALKTNASELVVLIPELCRVTGLNAEMRSNF 381
            :|:|||...|.|.:::.:|||||.:      |....||..    ::|:|||..:||:..:|:.:|
Human   451 TFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGE----ILLLPELSFMTGIPEKMKKDF 511

  Fly   382 QLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFH 446
            :.|:.::....::|||....|.....|:.....:...|..|.:.|.|:|.:::||::..:.|...
Human   512 RAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLK 576

  Fly   447 NGKVPAGENADWQRHF-RDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRS 510
            |......:..:|.:.. ||..:||.|   :..||:..|:|...:.|.|::.|.:.|..:|:|:..
Human   577 NTSFITSQELNWVKEVTRDPSILTIP---MHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSP 638

  Fly   511 PQEFIIYDDRTGTYVRAMDDCVRSDPK--LILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKT 573
            |....:.|||..||||.:...:.::.|  :::|::.....:.|.:|||...|...||:|||.::|
Human   639 PAWVELKDDRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRT 703

  Fly   574 T-KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQ 637
            . :...|.|:|.||.:|:|||||...|.:::||..||.||.|:........|:....:||::|..
Human   704 IGQPTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTL 768

  Fly   638 NSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKD 702
            ...|...|.:....::: ::|...:..:|:::...:..||.:||.||||||.|.||.:..:|:..
Human   769 TKWYSRVVFQMPHQEIV-DSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQ 832

  Fly   703 IIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFL----NGQNPPPGTIVDDVITLPERYDFYLVS 763
             ::|....:...|   |::...||.:.::|..:|    |...|.|||:||..||..|..||||::
Human   833 -LQKCFEAFENYQ---PKMVVFVVQKKISTNLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYLLA 893

  Fly   764 QQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNL 828
            ..||||...||.|..:.::..|||:.||:||:|:||:|:||.||.||||.|:||.|||.|.|..|
Human   894 HHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHIL 958

  Fly   829 HSIPQNALEKKFYYL 843
            |..|...|.:..::|
Human   959 HHEPAIQLCENLFFL 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	49/141 (35%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	147/451 (33%)
PIWIL2	NP_060538.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..199		9/55 (16%)
		ArgoL1	339..386	CDD:462567	17/46 (37%)
		PAZ_piwi_like	387..504	CDD:239211	46/120 (38%)
		Piwi_piwi-like_Euk	512..956	CDD:240016	147/451 (33%)