DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and PIWIL3

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001008496.2	Gene:	PIWIL3 / 440822	HGNCID:	18443	Length:	882	Species:	Homo sapiens

Alignment Length:	901	Identity:	292/901 - (32%)
Similarity:	469/901 - (52%)	Gaps:	90/901 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QGRGRRRPLNEDDSSTSRGSGDGPRV-------------------------------KVFRGSSS 38
            :||.|||      .|..:.:..|||.                               :..||.:.
Human    10 RGRARRR------ESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAG 68

  Fly    39 GDPRA----DPRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVML 99
            |..::    :|..||......|:|  ||.||..:......:.|..:.:.    ||.|::|..|.|
Human    69 GGAQSQGVKEPGPEAGLHTAPLQE--RRIGGVFQDLVVNTRQDMKHVKD----SKTGSEGTVVQL 127

  Fly   100 QTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKF-EQEI 163
            ..|.||:.::|:|....|:|:::|.||:..:|..:|..|....|..::|||..|..:|.. |:.:
Human   128 LANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRV 192

  Fly   164 TVLSGKSKLDIEYKISIKFVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIRE 228
            ..||.....:| .||:::|...::...|..|:..|::.||:.|.|:.|.||||.:..:..|::..
Human   193 EWLSTTKDKNI-VKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYR 256

  Fly   229 F--KMELWPGYETSIRQHEKDILLGTEITHKVMRTETIYDIMRRCSHNPARHQ-----DEVRVNV 286
            .  .:|:|.||.||:.|:|..|.|..:::||::|.||.||.::|.|   |:.|     :||...:
Human   257 HGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTS---AQAQTGNIREEVTNKL 318

  Fly   287 LDLIVLTDYNNRTYRINDVDFGQTPKSTFS-CKGRDISFVEYYLTKYNIRIRDHNQPLLISKNR- 349
            :..||||.|||:|||::|:|:.|.|:.||: ..|..|::::||..::...:....||||:|:.|
Human   319 IGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRW 383

  Fly   350 DKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPE 414
            .|.|.....|.::|||:||.:|||..|:..::.:::.::.:||::|::|...|:.|.:.||:..:
Human   384 KKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKK 448

  Fly   415 SVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWA 479
            ..::|:.|:::.|.|...|.||::...|||.....|.|....||.|..|:..:|....  |..|.
Human   449 VRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMP--LHSWL 511

  Fly   480 VIAPQRNSHELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKL------ 538
            ::..:.:..|..:|...|....:.||:.:: |.|.|..|....:|:..:....|  |.|
Human   512 ILYSRSSHREAMSLKGHLQSVTAPMGITMK-PAEMIEVDGDANSYIDTLRKYTR--PTLQMGMSC 573

  Fly   539 -----ILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLGYTP 598
                 ::|::|||:..||.|||:.......:|:|.|..||.:.....:|.||||.|:|||:|...
Human   574 LLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGAL 638

  Fly   599 WMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIA 663
            |.:|..:...|.:|.|......:|:::....:||.:.:....|...|.:.:. :.|...|...:.
Human   639 WKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTG-EELVKELEICLK 702

  Fly   664 KALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLSPPQ--LAYIVV 726
            .||..:......:|..::.|||||..|.|:.|.:.|.|.:...|||      :||..  ||:|||
Human   703 AALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKT------ISPNNFTLAFIVV 761

  Fly   727 TRSMNTRFFL----NGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSP 787
            .:.:||||||    |.|||||||::|..:|..|.|||::|||.|:.|||:||.|||:|.::||||
Human   762 KKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSP 826

  Fly   788 EKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLHSIPQNALEKKFYYL 843
            :.:|:|||.:||:|||..|..||||.|.||.|||.|||.::|..|..:|..:.:||
Human   827 DTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	33/110 (30%)
		PAZ	262..396	CDD:198017	50/140 (36%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	158/460 (34%)
PIWIL3	NP_001008496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		15/86 (17%)
		ArgoN	119..225	CDD:293095	32/106 (30%)
		PAZ_piwi_like	278..408	CDD:239211	51/132 (39%)
		Piwi_piwi-like_Euk	416..865	CDD:240016	158/460 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70885
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.720