DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and Piwil1

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_017453899.1	Gene:	Piwil1 / 363912	RGDID:	1306980	Length:	863	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	312/857 - (36%)
Similarity:	486/857 - (56%)	Gaps:	61/857 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPTERK 70
            ||||:|.:....:|.|:                     :.:|.|..:..:|.|    .||  .|:
  Rat    49 GRGRQRGMVVGATSKSQ---------------------ELQISAGFQELSLAE----RGG--RRR 86

  Fly    71 PWGDQYDY-LNTRP-AELV--SKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVR 131
               |.:|. :|||. .:.|  ||.|:.|:.|.|.||.|||.::|:|.:..||:::.|.:|..|:|
  Rat    87 ---DFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLR 148

  Fly   132 MGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRFLQV 196
            ..:|..|.:|:|..:.|||..||..::.:.::|.:..:::.....:|:|.....:....|..||.
  Rat   149 SALLFQHEDLIGRCHAFDGTILFLPKRLQHKVTEVFSQTRNGEHVRITITLTNELPPTSPTCLQF 213

  Fly   197 LNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVMRT 261
            .|:|.||.:|.:||:.:|||.::|...|:|...::.:|||:.|||.|:|.:|:|.|:::|||:|:
  Rat   214 YNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRLVIWPGFTTSILQYENNIMLCTDVSHKVLRS 278

  Fly   262 ETIYDIMRRCSHNPARH--QDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTF-SCKGRDIS 323
            ||:.|.|.........|  |::|...::.|||||.|||:|||::|:|:.|.||||| ...|.::|
  Rat   279 ETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKYNNKTYRVDDIDWDQNPKSTFKKADGSEVS 343

  Fly   324 FVEYYLTKYNIRIRDHNQPLLISK-NRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAM 387
            |:|||..:||..|.|..||:|:|: .|.:..........:||||||.:|||..:||::|.:|:.:
  Rat   344 FLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGLTDKMRNDFNVMKDL 408

  Fly   388 SSYTRMNPKQR---TDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGK 449
            :.:||:.|:||   ..||..:.|:..|..   :.||||.:..|.|:....|||:..:.|  |.|.
  Rat   409 AVHTRLTPEQRQREVGRLIDYIHKDDNVQ---RELRDWGLSFDSNLLSFSGRILQSEKI--HQGG 468

  Fly   450 VPAGEN---ADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSP 511
            .....|   |||.:..|...:::...  ||.|.:|..:||.....:|:.:|::....||::::.
  Rat   469 KTFDYNPQFADWSKETRGAPLISVKP--LDNWLLIYTRRNYEAANSLIQNLFKVTPAMGIQMKK- 530

  Fly   512 QEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTT-K 575
            ...|..||||..|:||:...|.||.::::||:.::..::|.:|||....|...|:|.|..:|. |
  Rat   531 AIMIEVDDRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVARTLGK 595

  Fly   576 NRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQNST 640
            .:::|:||||||:|:|||:|...|.:::||...|.:|.|....|...:|:....:||:: :..:.
  Rat   596 QQTVMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGIDCYHDTTAGRRSIAGFVASIN-EGMTR 659

  Fly   641 YFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIE 705
            :||..........|.:.|...:..|||.:...:..:|||::.|||||..|.||.|..:||...::
  Rat   660 WFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPSRVIVYRDGVGDGQLKTLVNYEVPQFLD 724

  Fly   706 KLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNG----QNPPPGTIVDDVITLPERYDFYLVSQQV 766
            .||:......   |:|..|||.:.:|.|||...    |||.|||::|..:|.||.|||::|||.|
  Rat   725 CLKSVGRGYN---PRLTVIVVKKRVNARFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAV 786

  Fly   767 RQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLHSI 831
            |.|:||||.|||:|.|.||.|:.:|:||||:||:||||.|..||||.||||.|||.|||.::|..
  Rat   787 RSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYNWPGVIRVPAPCQYAHKLAFLVGQSIHRE 851

  Fly   832 PQNALEKKFYYL 843
            |..:|..:.|||
  Rat   852 PNLSLSNRLYYL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	33/109 (30%)
		PAZ	262..396	CDD:198017	56/137 (41%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	170/454 (37%)
Piwil1	XP_017453899.1	GAGE	16..108	CDD:399085	22/88 (25%)
		PAZ	279..417	CDD:198017	56/137 (41%)
		Piwi_piwi-like_Euk	403..846	CDD:240016	170/454 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720