DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and Piwil4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_001355760.1	Gene:	Piwil4 / 330890	MGIID:	3041167	Length:	848	Species:	Mus musculus

Alignment Length:	863	Identity:	292/863 - (33%)
Similarity:	462/863 - (53%)	Gaps:	42/863 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPT--E 68
            ||.|.|........::|..|...|..:...:|.||..|........:...| .....:||.|  |
Mouse     3 GRARVRARGITTGHSAREVGRSSRDLMVTSASPGDSEAGGGTSVISQPYEL-GVSSGDGGRTFME 66

  Fly    69 RKPWGDQ-YDYLNTRPAELVS-----KKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIEN 127
            |:..|.| ::.|.....|.::     |.|:.|:||.|.||.|.|....:|::..|||.:.|.:.:
Mouse    67 RRGKGRQDFEELGVCTREKLTHVKDCKTGSSGIPVRLVTNLFNLDLPQDWQLYQYHVTYSPDLAS 131

  Fly   128 PRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPR 192
            .|:|:.:|.||:.|......|||..||.:.|.:|::|.|:.:::.....||::.....:....|.
Mouse   132 RRLRIALLYNHSILSDKAKAFDGASLFLSEKLDQKVTELTSETQRGETIKITLTLTSKLFPNSPV 196

  Fly   193 FLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHK 257
            .:|..|:|.|:.:|.|::..:|||.:.|...:||.::|:.||||:..|:...|..:|...::.:|
Mouse   197 CIQFFNVIFRKILKNLSMYQIGRNFYKPSEPVEIPQYKLSLWPGFAISVSHFESKLLFNADVNYK 261

  Fly   258 VMRTETIYDIM--------RRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKST 314
            |:|.||:.|.|        ..|.......|      ::.|:|||.|||:||||:|:|:...|...
Mouse   262 VLRNETVLDFMTDLCLRTGMSCFTEMCHKQ------LVGLVVLTRYNNKTYRIDDIDWSVKPTQA 320

  Fly   315 FSCK-GRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMR 378
            |..: |.::::|:||..:|:|.:.|.|||:|:|..:.|....:..::|.|:||||.:|||:::..
Mouse   321 FQKRDGSEVTYVDYYKQQYDITLSDLNQPVLVSLLKRKRNDNSEPQMVHLMPELCFLTGLSSQAT 385

  Fly   379 SNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNI 443
            |:|:||:|::..||::|..|..:|......:|..|.:...|..|.:.....:: :.||::..:.|
Mouse   386 SDFRLMKAVAEETRLSPVGRQQQLARLVDDIQRNPVARFELETWGLHFGSQLS-LTGRVVPSEKI 449

  Fly   444 VFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRI 508
            :..:........|||.:..|..::|:  |..|:||.::...|..|.:...|..|.|....||..:
Mouse   450 LLQDHTCQPAFAADWSKDMRSCKVLS--SQPLNRWLIVCCNRAEHLIEAFLSCLRRVGGSMGFNV 512

  Fly   509 RSPQEFIIYDDRTGTYVRAMDDCVRSDP--KLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTL 571
            ..| :.|..|:....::||:.  |..||  :|::|::|::....|.||||....|..||:|.|..
Mouse   513 GYP-KIIKVDETPAAFLRAIQ--VHGDPDVQLVMCILPSNQKNYYDSIKKYLSSDCPVPSQCVLT 574

  Fly   572 KT-TKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDL 635
            :| .|..:::|:|||||:|:.||||...|.:|:||..||.:|.||.:...::.......:||::.
Mouse   575 RTLNKQGTMLSVATKIAMQMTCKLGGELWSVEIPLKSLMVVGIDICRDALNKNVVVVGFVASINS 639

  Fly   636 QQNSTYFSTVTECSAFDVLANTLWPMIAKAL-RQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFE 699
            :....:...|.:.:|.|: |:.|...:..|| |.|:|.| .||:|||.|||||.:|.||.:.|:|
Mouse   640 RITRWFSRCVLQRTAADI-ADCLKVCMTGALNRWYRHNH-DLPARIVVYRDGVGNGQLKAVLEYE 702

  Fly   700 VKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNG----QNPPPGTIVDDVITLPERYDFY 760
            |..:::.: ||......| .:|:.:||.:....|.|.:.    ||||.||:||...|.||.||||
Mouse   703 VPQLLKSV-TECGSDARS-CRLSVVVVRKRCLLRLFASTDHTVQNPPLGTVVDSEATRPEWYDFY 765

  Fly   761 LVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVG 825
            |:||...:||||||.|||:|....|.|:.||:||:|:|||||||.|...|||.||||.||..||.
Mouse   766 LISQTANRGTVSPTHYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGLISVPAPCQYAHKLTFLVA 830

  Fly   826 TNLHSIPQNALEKKFYYL 843
            .::|..|...|....:||
Mouse   831 QSVHKEPSLELANNLFYL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	34/109 (31%)
		PAZ	262..396	CDD:198017	50/142 (35%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	165/451 (37%)
Piwil4	NP_001355760.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/48 (23%)
		PAZ	266..403	CDD:198017	50/142 (35%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	165/451 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837112
Domainoid	1	1.000	133	1.000	Domainoid score	I5041
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860