Protein Alignment piwi and Piwil2

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_006252333.2
• Gene: Piwil2 / 306011
• RGDID: 1306964
• Length: 1005
• Species: Rattus norvegicus
• Alignment Length: 861
• Identity: 277/861 - (32%)
• Similarity: 452/861 - (52%)
• Gaps: 55/861 - (6%)

  Fly     6 GRGRR----RPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGP 66
            |||..    .||.....|..||....|  ..| |.::.||   ||:.   :...|.........|
  Rat   177 GRGSSDVSLLPLGRAAGSIGRGVDKPP--SAF-GLTARDP---PRLP---QPPTLSPTSLHSSDP 232

  Fly    67 -----TERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIE 126
                 .|||            ..||:.|:|:.|.|..|..|..:::...| .:..|||.|.|::|
  Rat   233 PPVLTIERK------------EKELLVKQGSKGTPQSLGLNLIKIQCHNE-AVYQYHVTFSPNVE 284

  Fly   127 NPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEP 191
            ...:|.|:|.:|.::.|:...|||..|:...|.:|.:.:.|.:...|.|..|.|:....:.....
  Rat   285 CKSMRFGMLKDHQSVTGNVTAFDGSILYLPVKLQQLVELKSQRKTDDAEISIKIQLTKILEPCSD 349

  Fly   192 RFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITH 256
            ..:...|::.||.||.|:::|||||.:||.:.:.:::.::::||||..|||:.:..:.|..:::|
  Rat   350 LCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSH 414

  Fly   257 KVMRTETIYDIMRRC-SHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTF-SCKG 319
            ||:|.:::.|:|... ..|....|||....::..||:|.||||||||:|||:.:|||.:| ...|
  Rat   415 KVIRNDSVLDVMHAIYQQNKEHFQDECSKLLVGSIVITRYNNRTYRIDDVDWNKTPKDSFVMSDG 479

  Fly   320 RDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASEL----VVLIPELCRVTGLNAEMRSN 380
            ::|:|:|||...|.|.:::.:|||||  :|....:.|...|    ::|:|||..:||:..:|:.:
  Rat   480 KEITFLEYYSKNYGITVKEDDQPLLI--HRPSERQNNHGTLLKGEILLLPELSFMTGIPEKMKKD 542

  Fly   381 FQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVF 445
            |:.|:.::....::|||....|.....|:.....:...|..|.:.|.|:|.:::||::..:.|..
  Rat   543 FRAMKDLTQQINLSPKQHHSALECLLQRISQNETANNELTRWGLSLQKDVHKIEGRLLPMERINL 607

  Fly   446 HNGKVPAGENADWQRHF-RDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIR 509
            .|......|:.:|.:.. ||..:||.|   :..||:..|:|...:.|.|::.|.:.|..:|:||.
  Rat   608 RNTSFVTSEDLNWVKEVTRDASILTIP---MHFWALFYPKRAMDQARELVNMLEKIAGPIGMRIS 669

  Fly   510 SPQEFIIYDDRTGTYVRAMDDCVRSDPK--LILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLK 572
            .|....:.|||..||:|.:...:..:.|  :::|::.....:.|.:|||...|...||:||:.::
  Rat   670 PPAWVELKDDRIETYIRTIQSLLGVEGKIQMVVCIIMGTRDDLYGAIKKLCCVQSPVPSQVINVR 734

  Fly   573 TT-KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQ 636
            |. :...|.|:|.||.:|:|||||...|.:::||..||.||.|:........|:....:||::|.
  Rat   735 TIGQPTRLRSVAQKILLQMNCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLT 799

  Fly   637 QNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVK 701
            ....|...|.:....::: ::|...:..:|::|...:..||.:||.||||||.|.||.:..:|
  Rat   800 LTKWYSRVVFQMPHQEIV-DSLKLCLVGSLKKYYEVNHCLPEKIVVYRDGVSDGQLKTVANYE-- 861

  Fly   702 DIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNGQN----PPPGTIVDDVITLPERYDFYLV 762
              |.:|:..:.......|::...||.:.::|..:|...:    |.|||:||..||..|..||||:
  Rat   862 --IPQLQKCFEAFDNYHPKMVVFVVQKKISTNLYLAAPDHFVTPSPGTVVDHTITSCEWVDFYLL 924

  Fly   763 SQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTN 827
            :..||||...||.|..:.::..|||:.||:||:|:||:|:||.||.||||.|:||.|||.|.|..
  Rat   925 AHHVRQGCGIPTHYICVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGQI 989

  Fly   828 LHSIPQNALEKKFYYL 843
            ||..|...|.:..::|
  Rat   990 LHHEPAIQLCENLFFL 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	49/139 (35%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	147/451 (33%)
Piwil2	XP_006252333.2	ArgoL1	371..418	CDD:462567	17/46 (37%)
		PAZ_piwi_like	419..536	CDD:239211	46/118 (39%)
		Piwi_piwi-like_Euk	544..988	CDD:240016	147/451 (33%)