DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and wago-5

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_495151.3	Gene:	wago-5 / 191545	WormBaseID:	WBGene00022877	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	916	Identity:	180/916 - (19%)
Similarity:	310/916 - (33%)	Gaps:	262/916 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWR----IVHYHVEFEPSIENPRVRMG-----VLS 136
            |.|.|    .||.|..|.:.||.|.::...|..    :||...:...:.|....:.|     ||.
Worm    41 TTPTE----PGTLGKQVDVGTNIFGVEVTKETTVHRFVVHAKADLTSTKEVTFTKKGKEDFVVLD 101

  Fly   137 NH---ANLL---------------GSGYLFDGLQ-LFTTRKFEQEITVLSGKSKL---------- 172
            ..   .||.               |:..::||.. |:||.....|:.....|||:
Worm   102 RREKCCNLFFNAVEKNPDFFKMKDGNHIVYDGQSTLYTTINLFSELDCNQTKSKVFQINGADTGN 166

  Fly   173 -----------------DIEYKISIKFVG------FISCAEPRFLQVLNLILR----RSMKG--- 207
                             |....||.|.:|      .|......:.|.|.|.|.    |..|.
Worm   167 DELKTLPCISLEIHAPRDNSITISAKILGERTADQNIEVNNREYTQFLELALNQHCTRETKRFGC 231

  Fly   208 --------LNLELVGRNLFDPRAKIEIREFKMELWPGYETSIR---------QHEKDILL-GTEI 254
                    ||....|   ||.|..:::.:.| .|:||.:.:|:         |:...::: |.:.
Worm   232 FEHGKVYFLNATEEG---FDQRDCVDVGDGK-ALYPGLKKTIQFIEGPFGRGQNNPSLVIDGMKA 292

  Fly   255 T-HKVMRT-ETIYDIMRRCSHN----PARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKS 313
            . ||.... :.:::|..:...|    .||.:....:..||...:.....|..||..:.......:
Worm   293 AFHKEQTVIQKLFEITGQDPSNGLSSMAREKATPVIKGLDCYSMYTSRKRHLRIVGIFHESATGT 357

  Fly   314 TFSC-KGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDK------ALKTNASELVVLIPEL---- 367
            .|.. .|:..|..||:..||:|.::.....|::.|:|..      .|.|.:......||:.
Worm   358 RFELPDGKTCSIAEYFRDKYSINLQYPKANLVVCKDRGNNNYFPAELMTISKNQRATIPQQTQSQ 422

  Fly   368 -----CRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELD 427
                 |.|.   .::|...    .:...|.:|.....:.|.|...::.:.|..|.:     .||.
Worm   423 KTTKECAVL---PDVRQRI----IIKGKTAVNITAENELLNALGIKVYSEPLKVSL-----KELG 475

  Fly   428 KNVTEVQGRIIGQQNIVFHNGK--VPAGENADWQRHFRDQRMLTTPSDGLDRWAVIA-PQRNSH- 488
            ...:.|:..:          ||  .|.|.             ...|:...|.||:.| ..:||.
Worm   476 YQRSTVKSEL----------GKWRPPPGS-------------FVKPAAFQDLWALYAVGNQNSRF 517

  Fly   489 ---ELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCV-----RSDPKLILCLVPN 545
               :|.........|....|:.|:.|.|         |.:..||:.:     .:..|.....|..
Worm   518 SVSDLSQFTGMFIDACKKRGMIIKPPSE---------TSLCHMDNIISLLENAAASKCKFAFVIT 573

  Fly   546 DNA-----ERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQ-----LNCKLGYTPWM 600
            |::     ::|.:::::..:      .:..:|.:|..|::....::.::     .|.|||
Worm   574 DDSITHLHKKYKALEQKSMM------VIQDMKISKANSVVKDGKRLTLENVINKTNMKLG----- 627

  Fly   601 IELPLSGLMTIGFDIAKSTRDRKRAYGALIASMD-----LQQNSTYFSTVTECSAFDVLAN---- 656
                  ||.....|..||..|.:...|..:::..     :..|..:.:......|.:.:||
Worm   628 ------GLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFV 686

  Fly   657 --------------TLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEV------- 700
                          ::..::..::..::.....||.||:.||.|.|.||...:..:|:
Worm   687 GDFVLAPSGQDTMASIEDVLKSSIDLFEMNRNTLPKRIIIYRSGASDGSHASILAYEIPLARATI 751

  Fly   701 ----KDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFF---------LNGQNPPPGTIVDDVIT 752
                |||                .|.||:||:..:.|||         ....|.|||.::|..:|
Worm   752 QGYSKDI----------------NLIYIIVTKEHSYRFFRDQLRSGGKATEMNIPPGIVLDSAVT 800

  Fly   753 LPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVP----AV 813
            .|....|:|......|||.....|.:|........:::::|||.:||.:...:.:|.:|    ..
Worm   801 NPACKQFFLNGHTTLQGTAKTPLYTILADDCNAPMDRLEELTYTLCHHHQIVALSTSIPTPLYVA 865

  Fly   814 CQYAKK 819
            .:|||:
Worm   866 NEYAKR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	35/170 (21%)
		PAZ	262..396	CDD:198017	29/153 (19%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	97/507 (19%)
wago-5	NP_495151.3	ArgoN	47..>143	CDD:293095	22/95 (23%)
		PAZ_argonaute_like	297..407	CDD:239212	21/109 (19%)
		Piwi	568..876	CDD:280353	67/337 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920