DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and rde-1

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	NP_741611.1	Gene:	rde-1 / 179393	WormBaseID:	WBGene00004323	Length:	1020	Species:	Caenorhabditis elegans

Alignment Length:	936	Identity:	176/936 - (18%)
Similarity:	315/936 - (33%)	Gaps:	342/936 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DPRIEASRERRALEEAPRREGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLK- 107
            ||    :|..::||.|||.|.       |...|         :..|:..||.||:   ||..:.
Worm   231 DP----NRFEQSLEVAPRIEA-------WFGIY---------IGIKELFDGEPVL---NFAIVDK 272

  Fly   108 ---TKPEWRIVHYHVEF-EPSIENPRVRMGVLSNHANLLGSG-------------YLFDGLQLFT 155
               ..|:..::.|.:.. :|...|..||..:.:.    |.:|             .|.:.|:|..
Worm   273 LFYNAPKMSLLDYLLLIVDPQSCNDDVRKDLKTK----LMAGKMTIRQAARPRIRQLLENLKLKC 333

  Fly   156 TRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFD- 219
            ...::.|::            :::.:.:.|:...|...|  :..:..:|.:|.|.:.....||.
Worm   334 AEVWDNEMS------------RLTERHLTFLDLCEENSL--VYKVTGKSDRGRNAKKYDTTLFKI 384

  Fly   220 -------------PRAKIE--IREFKMELWPGYETSIRQHEKDILLGTEITHKVMRTETIYDI-- 267
                         |..|::  .:|:.:.:         :|       .|:..|..|.:...|:
Worm   385 YEENKKFIEFPHLPLVKVKSGAKEYAVPM---------EH-------LEVHEKPQRYKNRIDLVM 433

  Fly   268 ----MRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVD-FGQTPK-STFSCKGRDISFVE 326
                ::|.:..|..:::    |.|.::...|:::.  .:|.|: ||...| ....|.|:.:
Worm   434 QDKFLKRATRKPHDYKE----NTLKMLKELDFSSE--ELNFVERFGLCSKLQMIECPGKVL---- 488

  Fly   327 YYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAMSSYT 391
                         .:|:|::                                       :::...
Worm   489 -------------KEPMLVN---------------------------------------SVNEQI 501

  Fly   392 RMNPKQRTDRLRAFNHRLQN-TPE-----SVKVLRD--WNMELDKN-VTEVQGRIIGQQNIVFHN 447
            :|.|.     :|.|..:..| .||     :|.|:.:  .|..|::| |.:....:||  ...|..
Worm   502 KMTPV-----IRGFQEKQLNVVPEKELCCAVFVVNETAGNPCLEENDVVKFYTELIG--GCKFRG 559

  Fly   448 GKVPAGENADWQRHFRDQR-------MLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMG 505
            .::.|.||...|....|..       ...|.:.|:.|:.:.|.:                |..|.
Worm   560 IRIGANENRGAQSIMYDATKNEYAFYKNCTLNTGIGRFEIAATE----------------AKNMF 608

  Fly   506 LRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDR--AVPTQV 568
            .|:...::.:                      |:..::.......|..:|.  |.|.  .|..|.
Worm   609 ERLPDKEQKV----------------------LMFIIISKRQLNAYGFVKH--YCDHTIGVANQH 649

  Fly   569 VTLKTTKNRSLMS---------IATKIAIQLNCKLG-------------YTPWMIE----LPLSG 607
            :|.:|. .::|.|         |..:||:::|.|||             .:|...|    :||:
Worm   650 ITSETV-TKALASLRHEKGSKRIFYQIALKINAKLGGINQELDWSEIAEISPEEKERRKTMPLT- 712

  Fly   608 LMTIGFDIAKSTRDRKRAY--GALIASMD----LQQNSTYFSTVTEC-----------SAFDVLA 655
             |.:|.|:...|......|  .|::||::    :.:|  ...|..||           ...|:|.
Worm   713 -MYVGIDVTHPTSYSGIDYSIAAVVASINPGGTIYRN--MIVTQEECRPGERAVAHGRERTDILE 774

  Fly   656 NTLWPMIAKALRQY-QHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLS-- 717
                ....|.||:: ::...:.|:.||.||||||...:.::..    |.:..||:|..:....
Worm   775 ----AKFVKLLREFAENNDNRAPAHIVVYRDGVSDSEMLRVSH----DELRSLKSEVKQFMSERD 831

  Fly   718 ----PPQLAYIVVTRSMNTRFFLNGQ--------------------------------------N 740
                .|:..:||:.:..|||.....:                                      |
Worm   832 GEDPEPKYTFIVIQKRHNTRLLRRMEKDKPVVNKDLTPAETDVAVAAVKQWEEDMKESKETGIVN 896

  Fly   741 PPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWS 805
            |..||.||.:|....::||:|.|.....||..|..|.|:|...|:|.:::.|:||.:..|    |
Worm   897 PSSGTTVDKLIVSKYKFDFFLASHHGVLGTSRPGHYTVMYDDKGMSQDEVYKMTYGLAFL----S 957

  Fly   806 GTTRVP-----------AVCQYAKKL 820
            ...|.|           ..|:.||:|
Worm   958 ARCRKPISLPVPVHYAHLSCEKAKEL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	21/127 (17%)
		PAZ	262..396	CDD:198017	16/141 (11%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	116/556 (21%)
rde-1	NP_741611.1	PAZ_argonaute_like	280..419	CDD:239212	24/172 (14%)
rde-1	NP_741611.1	Piwi_ago-like	467..982	CDD:240015	123/634 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870