Protein Alignment piwi and wago-4

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_496751.1
• Gene: wago-4 / 174932
• WormBaseID: WBGene00010263
• Length: 965
• Species: Caenorhabditis elegans
• Alignment Length: 976
• Identity: 193/976 - (19%)
• Similarity: 346/976 - (35%)
• Gaps: 293/976 - (30%)

  Fly    66 PTERKPWGDQY-----------DYLNTRPAELV----SKKGTDGVPVMLQTNFFRLKTKPEWRIV 115
            |...:|...:|           :.||..||..:    ::.|..||...:|||.|.::...:....
 Worm    27 PVPTQPLRSEYQTSNDACIKRLEELNIAPAAKLYPTPTEPGKCGVEAEIQTNVFGIEMHQDSLFY 91

  Fly   116 HYHVEFEPSIENPR-----------------------VRMGVLSNHANLL----------GSGYL 147
            .|.|.....::|.:                       :....|.::....          |...|
 Worm    92 QYSVNITTELKNGKEVTFTKKGKDDFVVTERHDKCCAILFRALGDYEEFFKTSDSCLIYDGQSIL 156

  Fly   148 FDGLQLF-------TTRKFEQEITVLSG--------KSKLDIEYKI------SIKF--------- 182
            |..:.||       ...|:.|    |.|        ||...|:.::      ::||
 Worm   157 FSNVDLFQGFREGAVKTKYMQ----LDGGEMDHKDLKSLPCIKLEVFPTKNPAVKFTREAVARRA 217

  Fly   183 ----VGFISCAEPRFLQVLNLILRRSMKGLNLELV----GRNLF-DPRAK-------IEIREFKM 231
                :..:|.|   :.|:|.|.|.:.........|    |:..| ||..:       :::.:.|
 Worm   218 TDSNLDSVSLA---YQQILELALTQPCLRNTARYVVFDHGKMFFIDPLGEGFEKCDVVDVGDGK- 278

  Fly   232 ELWPGYETSI----------RQHEKDILLGTEIT-HKVMRTETIYDIMRRCSHNPARH------Q 279
            ::.||.:.:|          |.:...::.|.::. ||   .:.|.|.::..:..|..|      :
 Worm   279 QVVPGLKKTINFIEGPYGRGRSNPSVVIDGMKVAFHK---NQPILDKLKEITTQPVEHGLKGLEK 340

  Fly   280 DEVRVNVLDLIVLTDYNNRT--YRINDVDFGQTPKSTFSCK-GRDISFVEYYLTKYNIRIRDHNQ 341
            |.....:..|...:.|..|.  ::|..:.......:.|... |...:..:|:...|||.:|..:.
 Worm   341 DRCAAVIKGLDCYSTYGGRERHHKIEGIHHEGARNARFELNDGGSCTVAQYFEDVYNITLRYPDT 405

  Fly   342 PLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAM--SSYTRMNPKQRTDRLRA 404
            .|::||.|...                           ||..|..:  ||:.|:...|.|
 Worm   406 NLIVSKERGNI---------------------------NFYPMELLKISSHQRVQIPQLT----- 438

  Fly   405 FNHRLQNTPESVKVLRDWNMEL---DKNVTEV--QGRIIGQQNI-------VFHNGKVPAGE--N 455
             :.:.|.|.:...||.|....|   .||..::  ...::|:..:       :.....:||.:  |
 Worm   439 -SAQSQKTTKESAVLPDVRQRLILTGKNAAQISSDNEVLGKMGVSVCEDPLMVKGRSIPAVKLAN 502

  Fly   456 AD------------WQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAA------- 501
            |:            |:.:     ..|.|:...:.||:...  .:...|..||:|.:.|
 Worm   503 AEIGANPINVKDNKWRAN-----RFTRPATAPNVWAMYVV--GTASTRITLDTLKKFADEFAAMC 560

  Fly   502 SGMGLRIRSPQEF-IIYDD--RTGTYVRAMDDCVRSDPKLILCLVPNDNA----ERYSSIKKRGY 559
            ...|:.:.:|.:. :|:.|  .:..|.....:|.      .:.::.:|:.    :||..|:|
 Worm   561 KSKGVNMPAPADISLIHMDAIESRLYDATKANCT------FVFIITDDSITTLHQRYKMIEK--- 616

  Fly   560 VDRAVPTQVVT--LKTTKNRSLMSIATKIAIQ-----LNCKLGYTPWMI---ELPLSGLMTIGFD 614
                 .|:::.  :|.:|..|:::...::.::     .|.|||.:.::.   :..|...:.||..
 Worm   617 -----DTKMIVQDMKLSKALSVINAGKRLTLENVINKTNVKLGGSNYVFVDAKKQLDSHLIIGVG 676

  Fly   615 IAKSTRDRKRAY---GALIASM-----DLQQNSTYFST-VTECSAFDVLANTLWPMIAKALRQYQ 670
            |:......|.|.   |.|..::     :.|.|..:... |...::.|.|| .:..::..:|.:||
 Worm   677 ISAPPAGTKYAMENKGVLNPNVIGYAYNAQHNQEFSGDFVLNSASQDTLA-PIEDIVMHSLNEYQ 740

  Fly   671 HEH-RKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQL---SPP-QLAYIVVTRSM 730
            ..| ..||.|::.||.|.|.|:...:..:|:         ..||..:   ||. ||.||||::..
 Worm   741 KFHDGGLPRRVIVYRTGTSEGNHGSIMAYEI---------PLARAAMRDFSPDIQLVYIVVSKDH 796

  Fly   731 NTRFF------LNGQ-----------------------NPPPGTIVDDVITLPERYDFYLVSQQV 766
            :.|||      |..:                       |..||.:||.::|.|....|:|.|...
 Worm   797 SFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLNIAPGILVDSIVTNPACKQFFLNSHIT 861

  Fly   767 RQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVP----AVCQYAKKLATLVGTN 827
            .|||.....|.||.....:|...::.:|||:|||:......|.:|    ...:|||:     |.|
 Worm   862 LQGTAKTPLYTVLADDAKVSMTALEDITYKLCHLHQIVGLPTSLPTPLYVANEYAKR-----GRN 921

  Fly   828 L 828
            |
 Worm   922 L 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	26/144 (18%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	117/542 (22%)
wago-4	NP_496751.1	PLN03202	67..897	CDD:215631	178/904 (20%)
		PAZ_argonaute_like	316..426	CDD:239212	23/136 (17%)
		Piwi	594..924	CDD:396649	85/358 (24%)