Protein Alignment piwi and ppw-2

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_491535.1
• Gene: ppw-2 / 172152
• WormBaseID: WBGene00004094
• Length: 975
• Species: Caenorhabditis elegans
• Alignment Length: 1003
• Identity: 203/1003 - (20%)
• Similarity: 335/1003 - (33%)
• Gaps: 311/1003 - (31%)

  Fly    45 PRIEASRERRALEEA-------------PRREGGPTERKPWG------------------DQYDY 78
            |.:..:.|.:...:|             |:....|||...:|                  :.|.|
 Worm    40 PTLPVTSEHKTAHDACIKRLEQLEIPPDPKIYPSPTEPGTFGSVTEVLTNVFGVEVHKTSNFYQY 104

  Fly    79 LNTRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVH----------YHV-----EFEPSIENP 128
            .....|||.|||...          |..|.|.:: |||          :|.     :|..|.||.
 Worm   105 SVHITAELSSKKEVT----------FTKKGKEDF-IVHDRHEKCSAILFHALNRFEDFFKSSENC 158

  Fly   129 RVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRF 193
            .:..|    .:.|..|..||:|:   .|.|.:.::..::|..       .::|.:..:.|.:...
 Worm   159 IIYDG----QSILFTSMNLFEGI---PTGKIKTKVFQINGAD-------TNLKDLMVLPCIKLEV 209

  Fly   194 LQVLNLILRRSMKGLNLELVGRNLFDPR------AKIEIREFKMELWPGYETS---IRQHEKDIL 249
            ....|.::     ..:||.:||...|..      |..:|.:..|..:...|||   :.:|.|...
 Worm   210 FPTKNPVV-----NFSLEDIGRRTSDSNIESVNMAYKQILDLAMSQYAIRETSKCVVFEHGKMFF 269

  Fly   250 L-----------------GTEITHKVMRT-ETIYDIMRRCSHNP---------ARHQDEVRVNVL 287
            :                 |.::...:.:| :.|.....|..:||         |.|.:::....|
 Worm   270 INPLQEGYAPCDIVEVGDGKQMKPGLKKTLQFIEGPYGRNQNNPSIVIDGMKVAFHMEQLVFQKL 334

  Fly   288 DLIVL------------------------TDYNNRT--YRINDVDFGQTPKSTFSCKGRDISFV- 325
            ..|..                        ::|..||  ::|..:.......:.|..:|.....|
 Worm   335 SSITSNLANGITGSERERCAAVIKGLDCHSNYRGRTRHHKIESIHHEGAATARFELEGGGTCTVA 399

  Fly   326 EYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAMSSY 390
            .|:..||.|::|..|..|::.|.|. ||.....||:.:
 Worm   400 TYFKDKYKIQLRYPNANLIVCKERG-ALNFYPMELITI--------------------------- 436

  Fly   391 TRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMEL------------DKNVTEVQGRIIGQQNI 443
               :|.||....:..:.:.|.|.:...||.|....|            :..|....|..:..:.:
 Worm   437 ---SPNQRVRITQQTSSQSQRTTKESAVLPDIRQRLIMTGKIAAKITAENEVLGKMGVTVCDEPL 498

  Fly   444 VFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRW-------AVIAP-------------QRNSH 488
            |.....:||...|.    |.....|..|.|  .:|       :.:||             |.|..
 Worm   499 VVKGRNLPAIRLAS----FETGEHLINPRD--CKWRPQRYNRSAVAPKVWALYGVGSPGSQMNRD 557

  Fly   489 ELRTLLDSLYRAASGMGLRIRSPQEF-IIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNA---- 548
            .:|...|.....:...|:....|.:. ::..|.....:|   :...:....:|| :..||.
 Worm   558 VMRRFCDEFMNMSRSKGILFPPPGDVNLLTPDAIENRLR---EAANAGCTFVLC-ITEDNITCLH 618

  Fly   549 ERYSSIKKRGYVDRAVPTQVVT--LKTTKNRSLMSIATKIAIQ-----LNCKLG---YTPWMIEL 603
            ::|..|:..        ||::.  :|.:|..|:::.:.|:.::     .|.|||   |.....:.
 Worm   619 QKYKFIEHH--------TQMIVQDMKLSKALSVVNASKKLTLENVINKTNVKLGGSNYVYLDTKN 675

  Fly   604 PLSGLMTIGFDIAK---STRDRKRAYGALIASMDLQQNST-----YFSTVTECSAFDVLAN---- 656
            .|...:.||..|:.   .|:....:.|.|        |.|     |.....:..:.|.:.|
 Worm   676 FLQEHLIIGVGISSPPPGTKYIMESRGIL--------NPTIVGFAYNGNGKQEFSGDFVLNAAGQ 732

  Fly   657 -TLWP---MIAKALRQYQHEH-RKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQL 716
             |:.|   :::.:::.|:..| .|.|.||..||.|.|.|:...:..:||         ..|||.:
 Worm   733 ETIAPIEDIVSYSIKGYKKFHDGKAPKRITIYRSGSSEGNHGPIISYEV---------PLARVAM 788

  Fly   717 ---SP-PQLAYIVVTRSMNTRFF--------LNGQN-------------PP--------PGTIVD 748
               || .||.||||::....|||        ..|.|             ||        ||..||
 Worm   789 RNFSPDTQLLYIVVSKEHTYRFFKKESGGSSSGGSNSAGASNSGTLTSAPPKPWELNIGPGLTVD 853

  Fly   749 DVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVP-- 811
            ..:|.|....|:|.|....||:.....|.||.....:....:::.|:.:|||:......|.:|
 Worm   854 YGVTNPACKQFFLNSHMTLQGSAKTPLYTVLADDRNIGMSALEEFTFNLCHLHQIVGLPTSIPTP 918

  Fly   812 --AVCQYAKKLATLVGTNLHSIPQNALE 837
              ...:|||:     |.||.:...||.|
 Worm   919 LYVANEYAKR-----GRNLWNEAINANE 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	28/169 (17%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	115/544 (21%)
ppw-2	NP_491535.1	PAZ	334..461	CDD:198017	27/157 (17%)
		Piwi	604..934	CDD:396649	88/360 (24%)